Cefadroxil

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Cefadroxil
Cefadroxil.svg
Systematic (IUPAC) name
(6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names Generic
AHFS/Drugs.com monograph
MedlinePlus a682730
Legal status Rx Only
Routes Oral
Pharmacokinetic data
Protein binding plasma protein
Metabolism unknown
Half-life 1.5 hours
Identifiers
CAS number 66592-87-8 YesY
ATC code J01DB05
PubChem CID 47964
DrugBank DB01140
ChemSpider 43629 YesY
UNII 280111G160 YesY
KEGG D02353 YesY
ChEBI CHEBI:53667 YesY
ChEMBL CHEMBL1644 N
Chemical data
Formula C16H17N3O5S 
Mol. mass 363.389 g/mol
 N (what is this?)  (verify)

Cefadroxil (formerly trademarked as Duricef) is a broad-spectrum antibiotic of the cephalosporin type, effective in gram-positive and gram-negative bacterial infections. It is a bactericidal antibiotic.

General use[edit]

Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or Streptococcal tonsillitis, urinary tract infection, reproductive tract infection and skin infections.

Spectrum of bacterial resistance and susceptibility[edit]

Cefadroxil has a broad spectrum of activity and has been effective in treating bacteria responsible for causing tonsillitis, and infections of the skin and urinary tract. The following represents MIC susceptibility data for a few medically significant microorganisms.

  • Escherichia coli: 8 μg/mL
  • Staphylococcus aureus: 1 μg/mL – 2 μg/mL
  • Streptococcus pneumoniae: ≤1 μg/mL – >16 μg/mL

[1]

Pharmacokinetics[edit]

Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment.

Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk.

More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/mL have been reported after a dose of 500 mg. Cefadroxil is removed by haemodialysis.

Dosage[edit]

Cefadroxil is given by mouth, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil.
PO Adults. 500 mg–1g q12h; Peds. 15 mg/kg q12h; decrease in renal impair.

Side effects[edit]

The most common side effects of Cefadroxil are diarrhea (which, less commonly, may be bloody), nausea, upset stomach, and vomiting. Other side effects include:[2]

Dental use[edit]

Cefadroxil is used as an antibiotic prophylaxis before dental procedures, for patients allergic to penicillins.

Veterinary use[edit]

Can be used for treating infected wounds on animals. Usually in powder form mixed with water has a color and smell similar to Tang. Given orally to animals, amount dependent on their weight and severity of infection.

References[edit]