Cefadroxil
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| Systematic (IUPAC) name | |
| (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | |
| Clinical data | |
| Trade names | Duricef |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682730 |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Oral |
| Pharmacokinetic data | |
| Protein binding | plasma protein |
| Metabolism | unknown |
| Half-life | 1.5 hours |
| Identifiers | |
| CAS number | 66592-87-8  |
| ATC code | J01DB05 |
| PubChem | CID 47964 |
| DrugBank | APRD00196 |
| ChemSpider | 43629 |
| UNII | 280111G160 |
| KEGG | D02353 |
| ChEBI | CHEBI:53667 |
| ChEMBL | CHEMBL1644  |
| Chemical data | |
| Formula | C16H17N3O5S |
| Mol. mass | 363.389 g/mol |
| SMILES | eMolecules & PubChem |
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Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic.
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[edit] General use
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or Streptococcal tonsillitis, urinary tract infection, reproductive tract infection and skin infections.
[edit] Pharmacokinetics
Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment.
Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk.
More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/mL have been reported after a dose of 500 mg. Cefadroxil is removed by haemodialysis.
[edit] Dosage
Cefadroxil is given by mouth, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil.
[edit] Side effects
The most common side effects of Cefadroxil are diarrhoea (which, less commonly, may be bloody), nausea, upset stomach, and vomiting. Other side effects include[1]:
[edit] Dental use
Cefadroxil is used as an antibiotic prophylaxis before dental procedures.
(Always consider Amoxicillin plus Metronidazole as first line of treatment for dental procedures. In Case of penicillin allergy consider "Cefadroxil" for prophylaxis.)[citation needed]
[edit] Veterinary use
Can be used for treating infected wounds on animals. Usually in powder form mixed with water has a color and smell similar to Tang. Given orally to animals, amount dependent on their weight and severity of infection.
