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Isocodeine structure.svg
CAS number 509-64-8 YesY
ChemSpider 4481821
Jmol-3D images Image 1
Molecular formula C18H21NO3
Molar mass 299.36 g mol−1
Melting point 173 to 174 °C (343 to 345 °F; 446 to 447 K)[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Isocodeine is an opioid research chemical related to codeine. It is an epimer of codeine that can be prepared from it by a Mitsunobu reaction.[1]

Dozens of derivatives and analogs of isocodeine and the related compound isomorphine have been produced.[2][full citation needed]


  1. ^ a b Simon, Csaba; Hosztafi, Sándor; Makleit, Sándor (1991). "Application of the Mitsunobu Reaction for the Preparation of Isomorphine and Isocodeine Derivatives". Synthetic Communications 21 (3): 407–412. doi:10.1080/00397919108016763. 
  2. ^ "Report of Committee on drug addiction, 1929-1941". National Research Council (US).