para-Iodoamphetamine

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para-Iodoamphetamine
PIA structure.png
Systematic (IUPAC) name
1-(4-iodophenyl)propan-2-amine
Clinical data
Legal status ?
Identifiers
CAS number 21894-72-4 YesY
ATC code ?
PubChem CID 123870
Chemical data
Formula C9H12IN 
Mol. mass 261.103
 YesY (what is this?)  (verify)

para-Iodoamphetamine (PIA), also known as 4-iodoamphetamine (4-IA), is a research chemical of the phenethylamine and amphetamine chemical classes.

It acts as a selective serotonin releasing agent and is also a MAOI.[1]

PIA is rumored to be a serotonergic neurotoxin on the account of that being reported to be the case for para-chloroamphetamine.

However, PIA is a much weaker 5-HT neurotoxin than is the case for PCA.[2]

Analogs[edit]

5-IAI was an attempt to make a non-neurotoxic analog of PIA.

See also[edit]

References[edit]

  1. ^ Marona-Lewicka, D; Rhee, GS; Sprague, JE; Nichols, DE (1995). "Psychostimulant-like effects of p-fluoroamphetamine in the rat". European Journal of Pharmacology 287 (2): 105–13. doi:10.1016/0014-2999(95)00478-5. PMID 8749023.  edit
  2. ^ Nichols, DE; Johnson, MP; Oberlender, R (1991). "5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine". Pharmacology, Biochemistry, and Behavior 38 (1): 135–9. doi:10.1016/0091-3057(91)90601-W. PMID 1826785.  edit