Pentedrone

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Pentedrone
Pentedrone.svg
Systematic (IUPAC) name
(±)-1-phenyl-2-(methylamino)pentan-1-one
Clinical data
  • Schedule 1[1]
Identifiers
879722-57-3 N
None
ChemSpider 26286729 YesY
Chemical data
Formula C12H17NO
191.269 g/mol
 N (what is this?)  (verify)

Pentedrone, also known as 2-(methylamino)-1-phenylpentan-1-one or α-methylamino-valerophenone[citation needed], is a designer drug with stimulant effects, which has been found since 2010 as an ingredient in a number of "bath salt" mixes sold as legal highs.[2][3][4][5][6] On January 28, 2014, the DEA listed it, along with 9 other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.[1]

Pentedrone acts as a reuptake inhibitor for dopamine and norepinephrine without causing release, the same mechanism of action as methylphenidate.[7]

Pentedrone has been linked to at least one death where it was combined with α-PVP and caused heart failure.[8]

Detection[edit]

A forensic standard of Pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[9]

See also[edit]

References[edit]

  1. ^ a b "Temporary Placement of 10 Synthetic Cathinones into Schedule I". 28 January 2014. 
  2. ^ EMCDDA Annual Report 2010
  3. ^ Research on Head Shop drugs in Dublin: Part 2
  4. ^ An overview of new psychoactive substances and the outlets supplying them
  5. ^ Westphal F, Junge T, Girreser U, Greibl W, Doering C. Mass, NMR and IR spectroscopic characterization of pentedrone and pentylone and identification of their isocathinone by-products. Forensic Science International. 2011 Nov 23. PMID 22115724
  6. ^ Maheux CR, Copeland CR. Chemical analysis of two new designer drugs: buphedrone and pentedrone. Drug Testing and Analysis. 2011 Nov 24. DOI 10.1002/dta.385. PMID 22113925
  7. ^ Simmler, L. D.; Rickli, A.; Hoener, M. C.; Liechti, M. E. (2014). "Monoamine transporter and receptor interaction profiles of a new series of designer cathinones". Neuropharmacology 79: 152. doi:10.1016/j.neuropharm.2013.11.008.  edit
  8. ^ Sykutera, M.; Cychowska, M.; Bloch-Boguslawska, E. (2015). "A Fatal Case of Pentedrone and  -Pyrrolidinovalerophenone Poisoning". Journal of Analytical Toxicology. doi:10.1093/jat/bkv011.  edit
  9. ^ "Southern Association of Forensic Scientists url=http://forendex.southernforensic.org/index.php/detail/index/1164".