Ricasetron

Ricasetron
Clinical data
ATC code	none;
Identifiers
	IUPAC name endo-N-(8-methyl-8-azabicyclo[3.2.1]oct-3yl)-2,3-dihydro-3,3-dimethyl-indole-1-carboxamide;
CAS Number	117086-68-7 ;
PubChem CID	71785;
UNII	R92JB88O88;
ChEMBL	ChEMBL285999 ;
Chemical and physical data
Formula	C19H27N3O
Molar mass	313.436 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C4C2CCC(N2C)CC4NC(=O)N(CC1(C)C)c3c1cccc3;
	(what is this?) (verify)

Ricasetron (BRL-46470) is a drug which acts as a selective antagonist at the serotonin 5-HT₃ receptor.^[1] It has antiemetic effects as with other 5-HT₃ antagonists,^[2] and also has anxiolytic effects significantly stronger than other related drugs,^[3] and with less side effects than benzodiazepine anxiolytics.^[4]^[5] However, it has never been developed for medical use.

References

^ Newberry NR, Watkins CJ, Sprosen TS, Blackburn TP, Grahame-Smith DG, Leslie RA (August 1993). "BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors". Neuropharmacology. 32 (8): 729–35. doi:10.1016/0028-3908(93)90180-B. PMID 8413836.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Bermudez J, Sanger GJ (June 1994). "Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets". The Journal of Pharmacy and Pharmacology. 46 (6): 520–1. PMID 7932054.
^ Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N, Wood MD (1993). "BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties". Psychopharmacology. 110 (3): 257–64. doi:10.1007/BF02251279. PMID 7831418.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Link CG, Leigh TJ, Dennison JK (April 1993). "The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG". British Journal of Clinical Pharmacology. 35 (4): 395–9. PMC 1381550. PMID 8485019.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ de Souza Silva M, Guimarães FS, Graeff FG, Tomaz C (December 1993). "Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam". Behavioural Brain Research. 59 (1–2): 141–5. doi:10.1016/0166-4328(93)90160-R. PMID 8155281.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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[pmid8413836-1] Newberry NR, Watkins CJ, Sprosen TS, Blackburn TP, Grahame-Smith DG, Leslie RA (August 1993). "BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors". Neuropharmacology. 32 (8): 729–35. doi:10.1016/0028-3908(93)90180-B. PMID 8413836.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid7932054-2] Bermudez J, Sanger GJ (June 1994). "Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets". The Journal of Pharmacy and Pharmacology. 46 (6): 520–1. PMID 7932054.

[pmid7831418-3] Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N, Wood MD (1993). "BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties". Psychopharmacology. 110 (3): 257–64. doi:10.1007/BF02251279. PMID 7831418.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid8485019-4] Link CG, Leigh TJ, Dennison JK (April 1993). "The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG". British Journal of Clinical Pharmacology. 35 (4): 395–9. PMC 1381550. PMID 8485019.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid8155281-5] Souza Silva M, Guimarães FS, Graeff FG, Tomaz C (December 1993). "Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam". Behavioural Brain Research. 59 (1–2): 141–5. doi:10.1016/0166-4328(93)90160-R. PMID 8155281.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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