Thiobromadol

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Thiobromadol
C-8813.png
Systematic (IUPAC) name
trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol
Clinical data
Legal status
?
Identifiers
CAS number 616898-54-5 N
ATC code ?
PubChem CID 11058633
Chemical data
Formula C20H26BrNOS 
Mol. mass 408.394 g/mol
 N (what is this?)  (verify)

Thiobromadol (C-8813) is a potent μ-opioid receptor agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. The trans isomer was found to be around 591x more potent than morphine in animal studies.[1] The same study assigned a potency of 504x morphine to BDPC.

C-8813 is claimed to be similarly potent at the δ-opioid receptor, which antagonizes the mu depression of breathing, presumably making the drug safer.[1]

C-8813 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal. Tachyphylaxis would likely develop rapidly with repeated administration.

See also[edit]

References[edit]

  1. ^ a b Liu, Z. H.; Jin, W. Q.; Dai, Q. Y.; Chen, X. J.; Zhang, H. P.; Chi, Z. Q. (2003). "Opioid activity of C8813, a novel and potent opioid analgesic". Life Sciences 73 (2): 233–241. doi:10.1016/S0024-3205(03)00263-7. PMID 12738037.  edit