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| StdInChIKey = ZDXUKAKRHYTAKV-UHFFFAOYSA-N
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'''Lercanidipine''' is a [[calcium channel blocker]] of the [[dihydropyridine]] class.It is sold under various commercial names including '''Zanidip''',which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. This lowers the blood pressure and allows the heart to work more efficiently.<ref>{{Cite journal|pmid=17073834|year=2006|last1=Barrios|first1=V|last2=Escobar|first2=C|last3=Navarro|first3=A|last4=Barrios|first4=L|last5=Navarro-Cid|first5=J|last6=Calderón|first6=A|last7=Laura|first7=Investigators|title=Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study|volume=60|issue=11|pages=1364–70|doi=10.1111/j.1742-1241.2006.01176.x|pmc=1636683|journal=International journal of clinical practice}}</ref>
'''Lercanidipine''' is a [[calcium channel blocker]] of the [[dihydropyridine]] class,which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. It is sold under various commercial names including '''Zanidip'''. This lowers the blood pressure and allows the heart to work more efficiently.<ref>{{Cite journal|pmid=17073834|year=2006|last1=Barrios|first1=V|last2=Escobar|first2=C|last3=Navarro|first3=A|last4=Barrios|first4=L|last5=Navarro-Cid|first5=J|last6=Calderón|first6=A|last7=Laura|first7=Investigators|title=Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study|volume=60|issue=11|pages=1364–70|doi=10.1111/j.1742-1241.2006.01176.x|pmc=1636683|journal=International journal of clinical practice}}</ref>


== References ==
== References ==

Revision as of 12:26, 31 May 2012

Lercanidipine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 2[(3,3-diphenylpropyl)(methyl)amino]-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.235.079 Edit this at Wikidata
Chemical and physical data
FormulaC36H41N3O6
Molar mass611.727 g/mol g·mol−1
3D model (JSmol)
  • [O-][N+](=O)c1cccc(c1)C4C(=C(/N\C(=C4\C(=O)OC(C)(C)CN(CCC(c2ccccc2)c3ccccc3)C)C)C)\C(=O)OC
  • InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3 checkY
  • Key:ZDXUKAKRHYTAKV-UHFFFAOYSA-N checkY
  (verify)

Lercanidipine is a calcium channel blocker of the dihydropyridine class,which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. It is sold under various commercial names including Zanidip. This lowers the blood pressure and allows the heart to work more efficiently.[1]

References

  1. ^ Barrios, V; Escobar, C; Navarro, A; Barrios, L; Navarro-Cid, J; Calderón, A; Laura, Investigators (2006). "Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study". International journal of clinical practice. 60 (11): 1364–70. doi:10.1111/j.1742-1241.2006.01176.x. PMC 1636683. PMID 17073834.

Further reading

  • Lin T, Voon W, Yen H, Huang C, Su H, Lai W, Sheu S (2006). "Lercanidipine and losartan effects on blood pressure and fibrinolytic parameters". Kaohsiung J Med Sci. 22 (4): 177–83. doi:10.1016/S1607-551X(09)70304-3. PMID 16679299.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Martinez M, Lopes L, Coelho E, Nobre F, Rocha J, Gerlach R, Tanus-Santos J (2006). "Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension". J Cardiovasc Pharmacol. 47 (1): 117–22. doi:10.1097/01.fjc.0000196241.96759.71. PMID 16424795.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Agrawal R, Marx A, Haller H (2006). "Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension". J Hypertens. 24 (1): 185–92. doi:10.1097/01.hjh.0000198987.34588.11. PMID 16331117.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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