Codoxime: Difference between revisions

Codoxime
Clinical data
Other names	Codoxime
ATC code	none;
Legal status
Legal status	UN: Narcotic Schedule I;
Identifiers
	IUPAC name (((4,5α- Epoxy- 3-methoxy- 17-methylmorphinan- 6-ylidene) amino)oxy) acetic acid;
CAS Number	7125-76-0;
PubChem CID	9570253;
ChemSpider	7844721;
UNII	JT5I2F57F7;
KEGG	D03581;
ECHA InfoCard	100.027.660
Chemical and physical data
Formula	C20H24N2O5
Molar mass	372.415 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)CO\N=C4\[C@@H]5Oc1c2c(ccc1OC)C[C@H]3N(CC[C@]25[C@H]3CC4)C;

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Revision as of 13:20, 20 October 2012

Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6-ketone group has been replaced by carboxymethyloxime. It has primarily antitussive effects^[1] and was found to have moderate potential to cause dependence in animal studies.^[2]

References

^ Jack Fishman. Morphinone and Codeinone Derivatives. US Patent 3153042
^ Jasinski DR, Martin WR. Assessment of the dependence-producing properties of dihydrocodeinone and codoxime. Clinical Pharmacology and Therapeutics. 1967 Mar-Apr;8(2):266-70. PMID 6021586

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[1] Jack Fishman. Morphinone and Codeinone Derivatives. US Patent 3153042

[2] Jasinski DR, Martin WR. Assessment of the dependence-producing properties of dihydrocodeinone and codoxime. Clinical Pharmacology and Therapeutics. 1967 Mar-Apr;8(2):266-70. PMID 6021586

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 ==References==
 {{reflist}}
+{{Opioids}}
+[[Category:Opioids]]
 [[Category:Antitussives]]