Binaltorphimine

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Binaltorphimine
Binaltorphimine.svg
Systematic (IUPAC) name
(1S,2S,7S,8R,12S,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-22-methyl-19,25-dioxa-11,22,33-triazaundecacyclo​[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.018,37.030,36]​heptatriaconta-4(23),5(21),14(37),15,17,26(36),27,29-octaene-2,7,17,27-tetrol
Identifiers
CAS Number 105618-27-7
ATC code None
PubChem CID 5484197
ChemSpider 24673307
ChEMBL CHEMBL610001
Chemical data
Formula C41H45N3O6
Molar mass 675.813 g/mol

Binaltorphimine (BNI) is a selective antagonist of the κ-opioid receptor (KOR).[1] BNI and norbinaltorphimine (nor-BNI) were the first highly selective KOR antagonists to be discovered.[1]

See also[edit]

References[edit]

  1. ^ a b Portoghese PS, Lipkowski AW, Takemori AE (March 1987). "Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists". Life Sci. 40 (13): 1287–92. doi:10.1016/0024-3205(87)90585-6. PMID 2882399.