U-50488

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U-50488
U-50488 structure.svg
Ball-and-stick model of the U-50488 molecule
Systematic (IUPAC) name
2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
Identifiers
CAS Number 67198-13-4 YesY
PubChem CID 3036289
IUPHAR/BPS 1652
ChEBI CHEBI:73358 N
ChEMBL CHEMBL441765 N
Chemical data
Formula C19H26Cl2N2O
Molar mass 369.329 g/mol
 NYesY (what is this?)  (verify)

U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects.[1] It has analgesic, diuretic and antitussive effects,[2] and reverses the memory impairment produced by anticholinergic drugs.[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.[4][5]

See also[edit]

References[edit]

  1. ^ Von Voigtlander, PF; Lewis, RA (1982). "U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists". Progress in neuro-psychopharmacology & biological psychiatry 6 (4–6): 467–70. doi:10.1016/S0278-5846(82)80130-9. PMID 6298890. 
  2. ^ Kamei, J (1996). "Role of opioidergic and serotonergic mechanisms in cough and antitussives". Pulmonary pharmacology 9 (5–6): 349–56. doi:10.1006/pulp.1996.0046. PMID 9232674. 
  3. ^ Hiramatsu, M; Kameyama, T (1998). "Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models". Methods and findings in experimental and clinical pharmacology 20 (7): 595–9. doi:10.1358/mf.1998.20.7.485724. PMID 9819804. 
  4. ^ Szmuszkovicz, J (1999). "U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990". Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 52: 167–95. PMID 10396128. 
  5. ^ Szmuszkovicz, J (1999). "U-50,488 and the kappa receptor. Part II: 1991-1998". Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 53: 1–51. PMID 10616295.