Etonitazepipne: Difference between revisions

Etonitazepipne
Legal status
Legal status	DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act;
Identifiers
	IUPAC name 2-[(4-Ethoxyphenyl)methyl]-5-nitro-1-(2-piperidin-1-ylethyl)benzimidazole;
CAS Number	734496-28-7;
PubChem CID	162623834;
UNII	7AF6EZ8PMY;
Chemical and physical data
Formula	C23H28N4O3
Molar mass	408.502 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC1=CC=C(C=C1)CC2=NC3=C(N2CCN4CCCCC4)C=CC(=C3)[N+](=O)[O-];
	InChI InChI=1S/C23H28N4O3/c1-2-30-20-9-6-18(7-10-20)16-23-24-21-17-19(27(28)29)8-11-22(21)26(23)15-14-25-12-4-3-5-13-25/h6-11,17H,2-5,12-16H2,1H3; Key:UMGXRAISFRUVKD-UHFFFAOYSA-N;

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Revision as of 00:00, 19 June 2022

Etonitazepipne (N-Piperidino Etonitazene) is a benzimidazole derivative with opioid effects around 100 times more potent than morphine,^[1] which has been sold over the internet as a designer drug.^[2]^[3]^[4]^[5]

References

^ Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen". Helvetica Chimica Acta. 43 (4): 1032–1046. doi:10.1002/hlca.19600430412.
^ "Alert from NDEWS Web Monitoring Team: Increase in discussion of etonitazepipne". National Drug Early Warning System. Weekly Briefing (43). 9 July 2021.
^ "Warnings Etonitazepipne". Knowdrugs.app. 9 August 2021.
^ Vandeputte, Marthe M.; Verougstraete, Nick; Walther, Donna; Glatfelter, Grant C.; Malfliet, Jeroen; Baumann, Michael H.; Verstraete, Alain G.; Stove, Christophe P. (April 2022). "First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass". Archives of Toxicology. doi:10.1007/s00204-022-03294-2. ISSN 1432-0738. PMID 35449307.
^ Calello, Diane P.; Aldy, Kim; Jefri, Mohamed; Nguyen, Tuyet-Anh T.; Krotulski, Alex; Logan, Barry; Brent, Jeffrey; Wax, Paul; Walton, Sara; Manini, Alex F. (June 2022). "Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose". Clinical Toxicology: 1–3. doi:10.1080/15563650.2022.2084406. ISSN 1556-3650. PMID 35708103.

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[1] Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen". Helvetica Chimica Acta. 43 (4): 1032–1046. doi:10.1002/hlca.19600430412.

[2] "Alert from NDEWS Web Monitoring Team: Increase in discussion of etonitazepipne". National Drug Early Warning System. Weekly Briefing (43). 9 July 2021.

[3] "Warnings Etonitazepipne". Knowdrugs.app. 9 August 2021.

[4] Vandeputte, Marthe M.; Verougstraete, Nick; Walther, Donna; Glatfelter, Grant C.; Malfliet, Jeroen; Baumann, Michael H.; Verstraete, Alain G.; Stove, Christophe P. (April 2022). "First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass". Archives of Toxicology. doi:10.1007/s00204-022-03294-2. ISSN 1432-0738. PMID 35449307.

[5] Calello, Diane P.; Aldy, Kim; Jefri, Mohamed; Nguyen, Tuyet-Anh T.; Krotulski, Alex; Logan, Barry; Brent, Jeffrey; Wax, Paul; Walton, Sara; Manini, Alex F. (June 2022). "Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose". Clinical Toxicology: 1–3. doi:10.1080/15563650.2022.2084406. ISSN 1556-3650. PMID 35708103.

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-'''Etonitazepipne''' ('''N-Piperidino Etonitazene''') is a [[benzimidazole]] derivative with [[opioid]] effects around 100 times more potent than [[morphine]],<ref>{{cite journal | vauthors = Hunger A, Kebrle J, Rossi A, Hoffmann K | title = Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen. | journal = Helvetica Chimica Acta | date = 1960 | volume = 43 | issue = 4 | pages = 1032–1046 | doi = 10.1002/hlca.19600430412 }}</ref> which has been sold over the internet as a [[designer drug]].<ref>{{cite journal | title = Alert from NDEWS Web Monitoring Team: Increase in discussion of etonitazepipne | url = https://ndews.org/?wysija-page=1&controller=email&action=view&email_id=168&wysijap=subscriptions | journal = National Drug Early Warning System. Weekly Briefing | issue = 43 | date = 9 July 2021 }}</ref><ref>{{cite web | url = https://knowdrugs.app/drugs/Vm3RqXhdeiyRUXx7oRwW/Etonitazepipne | title = Warnings Etonitazepipne | work = Knowdrugs.app | date = 9 August 2021 }}</ref><ref>{{Cite journal| doi = 10.1007/s00204-022-03294-2| pmid = 35449307| issn = 1432-0738| last1 = Vandeputte| first1 = Marthe M.| last2 = Verougstraete| first2 = Nick| last3 = Walther| first3 = Donna| last4 = Glatfelter| first4 = Grant C.| last5 = Malfliet| first5 = Jeroen| last6 = Baumann| first6 = Michael H.| last7 = Verstraete| first7 = Alain G.| last8 = Stove| first8 = Christophe P.| title = First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass| journal = Archives of Toxicology| date = April 2022}}</ref>
+'''Etonitazepipne''' ('''N-Piperidino Etonitazene''') is a [[benzimidazole]] derivative with [[opioid]] effects around 100 times more potent than [[morphine]],<ref>{{cite journal | vauthors = Hunger A, Kebrle J, Rossi A, Hoffmann K | title = Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen. | journal = Helvetica Chimica Acta | date = 1960 | volume = 43 | issue = 4 | pages = 1032–1046 | doi = 10.1002/hlca.19600430412 }}</ref> which has been sold over the internet as a [[designer drug]].<ref>{{cite journal | title = Alert from NDEWS Web Monitoring Team: Increase in discussion of etonitazepipne | url = https://ndews.org/?wysija-page=1&controller=email&action=view&email_id=168&wysijap=subscriptions | journal = National Drug Early Warning System. Weekly Briefing | issue = 43 | date = 9 July 2021 }}</ref><ref>{{cite web | url = https://knowdrugs.app/drugs/Vm3RqXhdeiyRUXx7oRwW/Etonitazepipne | title = Warnings Etonitazepipne | work = Knowdrugs.app | date = 9 August 2021 }}</ref><ref>{{Cite journal| doi = 10.1007/s00204-022-03294-2| pmid = 35449307| issn = 1432-0738| last1 = Vandeputte| first1 = Marthe M.| last2 = Verougstraete| first2 = Nick| last3 = Walther| first3 = Donna| last4 = Glatfelter| first4 = Grant C.| last5 = Malfliet| first5 = Jeroen| last6 = Baumann| first6 = Michael H.| last7 = Verstraete| first7 = Alain G.| last8 = Stove| first8 = Christophe P.| title = First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass| journal = Archives of Toxicology| date = April 2022}}</ref><ref>{{cite journal|first1=Diane P.|last1=Calello|first2=Kim|last2=Aldy|first3=Mohamed|last3=Jefri|first4=Tuyet-Anh T.|last4=Nguyen|title=Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose|journal=Clinical Toxicology|date=June 2022|issn=1556-3650|pages=1–3|pmid=35708103|doi=10.1080/15563650.2022.2084406|first5=Alex|last5=Krotulski|first6=Barry|last6=Logan|first7=Jeffrey|last7=Brent|first8=Paul|last8=Wax|first9=Sara|last9=Walton|first10=Alex F.|last10=Manini}}</ref>
 == See also ==