ICI-204,448

ICI-204,448
Identifiers
	IUPAC name 2-(3-[1-([2-(3,4-dichlorophenyl)acetyl]-methylamino)-2-pyrrolidin-1-ylethyl]phenoxy)acetic acid;
CAS Number	121264-04-8 ;
PubChem CID	3683;
IUPHAR/BPS	1650;
ChemSpider	3555 ;
ChEBI	CHEBI:91666 ;
ChEMBL	ChEMBL23472 ;
CompTox Dashboard (EPA)	DTXSID20923747 ;
Chemical and physical data
Formula	C23H26Cl2N2O4
Molar mass	465.37 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C2CCCN2CC(c(ccc3)cc3OCC(O)=O)N(C)C(=O)Cc(cc1Cl)ccc1Cl;
	InChI InChI=1S/C23H26Cl2N2O4/c1-26(22(28)12-16-7-8-19(24)20(25)11-16)21(14-27-9-2-3-10-27)17-5-4-6-18(13-17)31-15-23(29)30/h4-8,11,13,21H,2-3,9-10,12,14-15H2,1H3,(H,29,30) ; Key:JKYJSFISYHSNOE-UHFFFAOYSA-N ;
	(what is this?) (verify)

ICI-204,448 is a drug which acts as a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as anti-itching effects.^[1]^[2] It is used in research to distinguish centrally from peripherally mediated kappa opioid receptor effects.^[3]^[4]

References

^ Peart JN, Gross ER, Gross GJ (March 2004). "Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction". Journal of Cardiovascular Pharmacology. 43 (3): 410–5. doi:10.1097/00005344-200403000-00012. PMID 15076225. S2CID 36736279.
^ Inan S, Cowan A (October 2004). "Kappa opioid agonists suppress chloroquine-induced scratching in mice". European Journal of Pharmacology. 502 (3): 233–7. doi:10.1016/j.ejphar.2004.09.010. PMID 15476749.
^ Schindler CW, Graczyk Z, Gilman JP, Negus SS, Bergman J, Mello NK, Goldberg SR (December 2007). "Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys". European Journal of Pharmacology. 576 (1–3): 107–13. doi:10.1016/j.ejphar.2007.07.053. PMC 2080578. PMID 17707792.
^ Shannon HE, Eberle EL, Mitch CH, McKinzie DL, Statnick MA (December 2007). "Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats". Neuropharmacology. 53 (8): 930–41. doi:10.1016/j.neuropharm.2007.09.002. PMID 17959202. S2CID 38651220.

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[pmid15076225-1] Peart JN, Gross ER, Gross GJ (March 2004). "Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction". Journal of Cardiovascular Pharmacology. 43 (3): 410–5. doi:10.1097/00005344-200403000-00012. PMID 15076225. S2CID 36736279.

[pmid15476749-2] Inan S, Cowan A (October 2004). "Kappa opioid agonists suppress chloroquine-induced scratching in mice". European Journal of Pharmacology. 502 (3): 233–7. doi:10.1016/j.ejphar.2004.09.010. PMID 15476749.

[pmid17707792-3] Schindler CW, Graczyk Z, Gilman JP, Negus SS, Bergman J, Mello NK, Goldberg SR (December 2007). "Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys". European Journal of Pharmacology. 576 (1–3): 107–13. doi:10.1016/j.ejphar.2007.07.053. PMC 2080578. PMID 17707792.

[pmid17959202-4] Shannon HE, Eberle EL, Mitch CH, McKinzie DL, Statnick MA (December 2007). "Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats". Neuropharmacology. 53 (8): 930–41. doi:10.1016/j.neuropharm.2007.09.002. PMID 17959202. S2CID 38651220.

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