Pinacidil

Pinacidil
Names
	IUPAC name N-cyano-N'-pyridin-4-yl-N''-(1,2,2-trimethylpropyl)guanidine
Identifiers
CAS Number	85371-64-8 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1159 ; ChEMBL1200338 ;
ChemSpider	4660 ;
ECHA InfoCard	100.056.614
IUPHAR/BPS	2412;
PubChem CID	4826;
UNII	BB4UGO5K0D ;
CompTox Dashboard (EPA)	DTXSID7048249 ;
	InChI InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18) Key: IVVNZDGDKPTYHK-UHFFFAOYSA-N ; InChI=1/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18) Key: IVVNZDGDKPTYHK-UHFFFAOYAY;
	SMILES CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1;
Properties
Chemical formula	C13H19N5
Molar mass	245.32346
Pharmacology
ATC code	C02DG01 (WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.^[1] It reduces blood pressure and peripheral resistance and produces fluid retention.^[2]

References

^ Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H (1995). "Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells". J. Pharmacol. Exp. Ther. 275 (2): 681–92. PMID 7473155.
^ Reynolds, James Blair; Martindale, William L. (1996). The extra pharmacopoeia (31st ed.). London: Royal Pharmaceutical Society. pp. 2739 pages. ISBN 0-85369-342-0.

Pinacidil at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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