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L-687,384

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This is an old revision of this page, as edited by DMacks (talk | contribs) at 15:21, 22 June 2020 (Remove malformatted |molecular_weight= when infobox can autocalculate it, per Wikipedia talk:WikiProject Pharmacology#Molecular weights in drugboxes (via WP:JWB)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

L-687,384
Clinical data
ATC code
  • none
Identifiers
  • 1'-benzylspiro[2,3-dihydro-1H-naphthalene-4,4'-piperidine]
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H25N
Molar mass291.438 g·mol−1
3D model (JSmol)
  • c3ccccc3CN2CCC1(CC2)CCCc4c1cccc4
  • InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2 ☒N
  • Key:MLDCBJPLHBPJET-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

L-687,384 is a sigma receptor agonist, selective for the σ1 subtype,[1] as well as an NMDA antagonist.[2]

References

  1. ^ Bergeron R, Debonnel G (February 1997). "Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors". Psychopharmacology. 129 (3): 215–24. doi:10.1007/s002130050183. PMID 9084059.
  2. ^ McLarnon J, Sawyer D, Church J (June 1994). "The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons". Neuroscience Letters. 174 (2): 181–4. doi:10.1016/0304-3940(94)90016-7. PMID 7526288.


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