Α-Methylthiofentanyl

Α-Methylthiofentanyl
Clinical data
Other names	α-methyl-thiofentanyl
ATC code	none;
Legal status
Legal status	CA: Schedule I; DE: Anlage I (Authorized scientific use only); UK: Class A; US: Schedule I;
Identifiers
	IUPAC name N-phenyl-N-[1-(1-thiophen-2-ylpropan-2-yl)-4-piperidyl]propanamide;
CAS Number	103963-66-2 ;
PubChem CID	62309;
DrugBank	DB01470 ;
ChemSpider	56104 ;
UNII	NF684LIF79;
CompTox Dashboard (EPA)	DTXSID90861243 ;
Chemical and physical data
Formula	C21H28N2OS
Molar mass	356.526 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N(c1ccccc1)C2CCN(CC2)C(Cc3sccc3)C)CC;
	InChI InChI=1S/C21H28N2OS/c1-3-21(24)23(18-8-5-4-6-9-18)19-11-13-22(14-12-19)17(2)16-20-10-7-15-25-20/h4-10,15,17,19H,3,11-14,16H2,1-2H3 ; Key:YPOXDUYRRSUFFG-UHFFFAOYSA-N ;
	(verify)

α-methyl-thiofentanyl is an opioid analgesic that is an analogue of fentanyl.

α-methyl-thiofentanyl was sold briefly on the black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared.^[1]

α-methyl-thiofentanyl has similar effects to fentanyl. Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.^[2]

References

^ Henderson, GL (1988). "Designer Drugs: Past History and Future Prospects". Journal of Forensic Sciences. 33 (2): 569–575.
^ Jane Mounteney; Isabelle Giraudon; Gleb Denissov; Paul Griffiths (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe". The international journal of drug policy. 26 (7): 626–631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511.

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[1] Henderson, GL (1988). "Designer Drugs: Past History and Future Prospects". Journal of Forensic Sciences. 33 (2): 569–575.

[2] Jane Mounteney; Isabelle Giraudon; Gleb Denissov; Paul Griffiths (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe". The international journal of drug policy. 26 (7): 626–631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511.

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