Angiopoietin 1

ANGPT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EPU, 4JYO, 4K0V
Identifiers
Aliases	ANGPT1, AGP1, AGPT, ANG1, angiopoietin 1, HAE5, AGPT-1
External IDs	OMIM: 601667; MGI: 108448; HomoloGene: 37447; GeneCards: ANGPT1; OMA:ANGPT1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q23.1 Start 107,249,482 bp End 107,498,055 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 B3.1|15 16.69 cM Start 42,288,119 bp End 42,540,373 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung Achilles tendon optic nerve right lung popliteal artery seminal vesicula urethra stromal cell of endometrium visceral pleura gallbladder Top expressed in atrium atrioventricular valve blood intercostal muscle digastric muscle molar right lung soleus muscle right ventricle left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding protein binding signaling receptor binding Cellular component plasma membrane microvillus membrane raft extracellular exosome extracellular region intracellular anatomical structure extracellular space Biological process negative regulation of neuron apoptotic process negative regulation of protein phosphorylation negative regulation of endothelial cell apoptotic process negative regulation of cell adhesion cell differentiation hemopoiesis positive regulation of protein kinase B signaling heparin biosynthetic process positive regulation of receptor internalization regulation of tumor necrosis factor production transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of cytokine production involved in immune response sprouting angiogenesis in utero embryonic development negative regulation of apoptotic process positive regulation of peptidyl-serine phosphorylation MAPK cascade positive regulation of endothelial cell migration multicellular organism development cell-substrate adhesion protein localization to cell surface angiogenesis positive regulation of blood vessel endothelial cell migration positive regulation of ERK1 and ERK2 cascade regulation of macrophage migration inhibitory factor signaling pathway regulation of endothelial cell proliferation positive regulation of phosphatidylinositol 3-kinase signaling positive chemotaxis activation of transmembrane receptor protein tyrosine kinase activity regulation of protein binding regulation of skeletal muscle satellite cell proliferation positive regulation of protein ubiquitination leukocyte migration regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of protein import into nucleus positive regulation of cell adhesion glomerulus vasculature development negative regulation of vascular permeability Tie signaling pathway positive regulation of peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284 11600 Ensembl ENSG00000154188 ENSMUSG00000022309 UniProt Q15389 O08538 RefSeq (mRNA) NM_001146 NM_001199859 NM_001314051 NM_139290 NM_009640 NM_001286062 RefSeq (protein) NP_001137 NP_001186788 NP_001300980 NP_001272991 NP_033770 Location (UCSC) Chr 8: 107.25 – 107.5 Mb Chr 15: 42.29 – 42.54 Mb PubMed search
Wikidata
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Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

Interactions

Angiopoietin 1 has been shown to interact with TEK tyrosine kinase.

Placental Malaria

Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with Plasmodium (the causative agent of malaria). In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. This suggests that angiopoietin levels could be clinically significant biomarkers to identify mothers infected with PM.

See also

• Angiopoietin

External links

• Human ANGPT1 genome location and ANGPT1 gene details page in the UCSC Genome Browser.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.