Charles Yanofsky

Charles Yanofsky
Born	(1925-04-17) April 17, 1925 New York
Nationality	United States
Awards	National Medal of Science (2003) Louisa Gross Horwitz Prize(1976) Selman A. Waksman Award in Microbiology (1972)
Scientific career
Fields	Genetics
Institutions	Stanford University

Charles Yanofsky (born April 17, 1925) is a leading American geneticist.

Born in New York, Yanofsky studied at the City College of New York and at Yale University.

In 1964, Yanofsky and colleagues established that gene sequences and protein sequences are colinear in bacteria. This had previously been demonstrated in humans by studies of sickle cell anemia. Yanofsky showed that changes in DNA sequence can produce changes in protein sequence at corresponding positions. His work revealed how controlled alterations in RNA structure allow RNA to serve as a regulatory molecule in both bacterial and animal cells.

Yanofsky was awarded the Selman A. Waksman Award in Microbiology from the National Academy of Sciences in 1972 and was co-recipient of the Louisa Gross Horwitz Prize from Columbia University in 1976 with Seymour Benzer. Yanofsky was elected a foreign member of the Royal Society in 1985 and was one of the recipients of the 2003 National Medal of Science awards.

Charles Yanofsky is now the Morris Herzstein Professor of Biology and Molecular Biology (Emeritus) at Stanford University.

Articles

• Yanofsky, Charles (2007), "RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria", RNA, vol. 13, no. 8 (published 2007 Aug), pp. 1141–54, doi:10.1261/rna.620507, PMC 1924887, PMID 17601995 {{citation}}: Check date values in: |publication-date= (help)
• Yanofsky, Charles (2005), "The Favorable Features of Tryptophan Synthase for Proving Beadle and Tatum's One Gene–One Enzyme Hypothesis", Genetics, vol. 169, no. 2 (published 2005 Feb), pp. 511–6, PMC 1449131, PMID 15731515 {{citation}}: Check date values in: |publication-date= (help)
• Yanofsky, Charles (2004), "The different roles of tryptophan transfer RNA in regulating trp operon expression in E. coli versus B. subtilis", Trends Genet., vol. 20, no. 8 (published 2004 Aug), pp. 367–74, doi:10.1016/j.tig.2004.06.007, PMID 15262409 {{citation}}: Check date values in: |publication-date= (help)
• Yanofsky, C (2000), "Transcription Attenuation: Once Viewed as a Novel Regulatory Strategy", J. Bacteriol., vol. 182, no. 1 (published 2000 Jan), pp. 1–8, doi:10.1128/JB.182.1.1-8.2000, PMC 94232, PMID 10613855 {{citation}}: Check date values in: |publication-date= (help)
• Yanofsky, C; Konan, K V; Sarsero, J P (1996), "Some novel transcription attenuation mechanisms used by bacteria", Biochimie, vol. 78, no. 11–12, pp. 1017–24, doi:10.1016/S0300-9084(97)86725-9, PMID 9150880
• Yanofsky, C (1988), "Transcription attenuation", J. Biol. Chem., vol. 263, no. 2 (published 1988 Jan 15), pp. 609–12, PMID 3275656 {{citation}}: Check date values in: |publication-date= (help)
• Yanofsky, C; Platt, T; Crawford, I P; Nichols, B P; Christie, GE; Horowitz, H; Vancleemput, M; Wu, AM (1981), "The complete nucleotide sequence of the tryptophan operon of Escherichia coli", Nucleic Acids Res., vol. 9, no. 24 (published 1981 Dec 21), pp. 6647–68, doi:10.1093/nar/9.24.6647, PMC 327632, PMID 7038627 {{citation}}: Check date values in: |publication-date= (help)
• Yanofsky, C (1981), "Attenuation in the control of expression of bacterial operons", Nature, vol. 289, no. 5800 (published 1981 Feb 26), pp. 751–8, doi:10.1038/289751a0, PMID 7007895 {{citation}}: Check date values in: |publication-date= (help)
• Yanofsky, C (1971), "Tryptophan biosynthesis in Escherichia coli. Genetic determination of the proteins involved", JAMA, vol. 218, no. 7 (published 1971 Nov 15), pp. 1026–35, doi:10.1001/jama.218.7.1026, PMID 4940311 {{citation}}: Check date values in: |publication-date= (help)
• Yanofsky, C (1967), "Gene structure and protein structure", Harvey Lect., vol. 61, pp. 145–68, PMID 5338072

External links

• Stanford link
• The Official Site of Louisa Gross Horwitz Prize