List of Grey's Anatomy characters
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Grey's Anatomy is an American television medical drama series created by Shonda Rhimes, broadcast by ABC. The show features an ensemble cast of regular characters, with nine main characters in its first season. Since the first season, many characters have left the show or have been written out, and new main characters have been written in and out of the series. Following is a list of characters who have appeared over the various seasons since the drama's premiere.
- 1 Main characters
- 2 Chiefs of Surgery
- 3 Department Chiefs
- 4 Attending Physicians
- 5 Surgical Fellows
- 6 Resident Physicians
- 7 Supporting characters
- 8 References
- 9 External links
Chiefs of Surgery
|Name||Actor/actress||Starring seasons||Recurring seasons||Occupation at Grey Sloan
(or its predecessors)
|Miranda Bailey||Chandra Wilson||1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15||N/A||Chief of Surgery, Attending General Surgeon, Member of the Board||M.D., FACS|
|An attending general surgeon at Seattle Grace hospital, Miranda Bailey initially gives a cold, domineering impression, earning her the nickname "The Nazi". However, her attitude has since softened, and she has developed a maternal demeanor towards the residents in the hospital. She has gone through a divorce, which led her to turn down a fellowship in pediatric surgery. After having a short-lived relationship with a nurse, Eli, she dates anesthesiologist Ben Warren, whom she eventually marries. In Season 10, Bailey discovers that she has OCD and is forced to work with an occupational therapist to help her get control of her disorder. Eventually, Bailey decides to start taking a medication that will help control it. In Season 12, Dr. Bailey is named Chief of Surgery, making her the first female Chief in the history of the hospital. In Season 15, Bailey takes a temporary leave from the Chief of Surgery position and takes some time away from Ben.|
|Owen Hunt||Kevin McKidd||5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15||5||Chief of Trauma Surgery, Attending Trauma Surgeon, Former Chief of Surgery||M.D., FACS|
|Entering the series as a tough veteran, Owen Hunt immediately begins a relationship with Cristina Yang. He has post-traumatic stress disorder and has struggled with the horrors he experienced whilst serving with the army in Iraq. He invites a former colleague, Teddy Altman, to work alongside him, a decision that causes some friction between him and Cristina. In the Season 7 premiere, he marries Cristina. After Webber resigns, he is given the position of Chief of Surgery. He and Cristina experience marital problems after his affair with a woman at a bar is revealed; they also continue to disagree over the fact that Cristina does not want kids. They try to resolve their issues, but they eventually divorce. Still, after they divorce, they continue to see each other until the end of Season 9 when she decides to let him go. In Season 10, he starts a relationship with Emma Marling, an attending at Seattle Presbyterian, but they break up due to their different values in life. He starts to sleep with Cristina again until she moves to Zurich, ending their relationship for good. At the end of Season 11, Owen begins a relationship with Amelia Shepherd, and they marry in the Season 12 finale. However, even at the start of their marriage, they begin to have problems, partially due to the fact that they got married so impulsively. They start living apart, and by Season 14, they decide to get a divorce when Amelia discovers she has a brain tumor that had been impeding on her judgement for the last 10 years, including her decision to marry Owen. Since then, Owen has had flings with Carina DeLuca and Teddy, both of which have failed. In Season 15, he and Amelia get back together and he learns that Teddy is pregnant with his baby.|
|Alex Karev||Justin Chambers||1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15||N/A||Interim Chief of Surgery, Chief of Pediatric Surgery, Attending Pediatric Surgeon, Grey Sloan Shareholder||M.D., FACS|
|A hard-headed and often discourteous resident, Alex Karev has had a series of unfortunate relationships throughout his life, beginning with his mother. At an early age, he had to defend her and his siblings from an abusive father, then later take care of her when she struggled with schizophrenia. While working as a doctor, he becomes involved with a patient, Ava. However, her mental instability strains their relationship and Alex, once again, adopts the role of caretaker before Ava's admission to a psychiatric hospital. He subsequently embarks on a relationship with Izzie Stevens, and they get married, but Izzie asks for a divorce following her dismissal from Seattle Grace. In the Season 8 finale, he is meant to fly with other surgeons to perform a procedure at Boise Memorial. However, after he states his intention to do his pediatric surgical fellowship at the Johns Hopkins Hospital to Dr. Robbins, she replaces him out of anger. In the Season 9 premiere, he is supposed leave Seattle Grace, having deferred his fellowship in the aftermath of the plane crash. After he realizes the drastic changes that will happen in both his and Dr. Robbins' absence, due to the hiring of a new Chief of Pediatric Surgery, he changes his mind and stays on at Seattle Grace. In the Season 9 finale, he starts a relationship with surgical intern Jo Wilson. In Season 10, he completes his fellowship and goes to work for Dr. Lebackes at a private practice, which saw him make a substantial salary. However, after being fired when Lebackes found out he was up for a position on the Grey Sloan board, he returned to Grey Sloan and took his current position. He and Jo start to have problems in their relationship, which only worsen when she turns down his marriage proposal. In the Season 12 finale, he finds a drunk Jo with Andrew DeLuca, and he assumes that DeLuca is taking advantage of Jo, leading to Alex beating DeLuca up. This results in Alex getting charged with a felony, but DeLuca eventually drops the charges. Jo has trouble trusting Alex and is afraid of his inability to mask his rage, but they get back together in the Season 14 premiere when he proves that he would never be violent with her; soon after, they become engaged. In the Season 14 finale, Alex and Jo get married. In the Season 15 premiere, Alex is named interim Chief of Surgery.|
|Derek Shepherd||Patrick Dempsey||1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11||N/A||Attending Neurosurgeon, Director of the Board, Grey Sloan Shareholder, Former Chief of Surgery||M.D, FACS|
|As Chief of Neurosurgery, Derek Shepherd earns the nickname "McDreamy" from the female staff of Seattle Grace. As the lead male character, he is known for his complicated love life. He initially moves to Seattle from New York City to get away from his ex-wife, Addison Montgomery, whom he discovered was having an affair with his best friend, Mark Sloan. He subsequently begins a long romance with Meredith Grey, which is on-and-off until their marriage in Season 5. He takes over as the Chief of Surgery after going to the hospital board about Chief Webber's drinking problem. He resigns after nearly dying from being shot because he thinks being Chief isn't his place, after which Webber is reinstated. He and Meredith adopt an orphan named Zola from Africa at the beginning of Season 8, despite initially having problems with the adoption process. After surviving the plane crash in the Season 8 finale, his sister donates a nerve to repair his injured hand. Although he and Meredith struggle with fertility problems, Meredith gives birth to their son Bailey in the Season 9 finale. In Season 10, Derek starts to work with the president on a brain mapping project, using technology that he and Callie created. He wants to move to DC with his family, but Meredith doesn't want to leave Seattle. This creates tension in their marriage, and Derek's decision to leave for DC without Meredith only worsens. Eventually, Derek decides to leave Seattle and reconciles with Meredith; not long after, he dies of a head injury after his car is T-Boned by a semi-truck at the end of Season 11.|
|Richard Webber||James Pickens, Jr.||1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15||N/A||Senior Attending General Surgeon, Member of the Board, Director of the Residency Program, Grey Sloan Shareholder, Former Chief of Surgery||M.D., FACS|
|An authority figure and longtime Chief of Surgery at Seattle Grace, Richard Webber has had a difficult past, characterized by affairs and alcoholism. His relationship with Meredith Grey is at times volatile because he had an affair with her mother, Ellis Grey. Richard has struggled with managing the finances of Seattle Grace Hospital and had eventually merged the hospital with Mercy West Hospital. The merger has caused him a lot of stress, strained his relationship with Derek Shepherd and ultimately contributes to the collapse of his sobriety. He steps down as Chief of Surgery in Season 8 after taking the blame for tampering with Derek's clinical trial (which Meredith had done to help Richard's wife, Adele), although because he has been chief for so long, the residents still call him "Chief." Outside of the hospital, Richard deals with marital problems with his wife, Adele, who later gets Alzheimer's and eventually dies from it. When Adele no longer recognizes him, Richard starts a relationship with Catherine Avery, whom he marries at the end of Season 11. Though they have their own issues, they eventually reconcile and are stronger than ever. At the end of Season 10, Richard meets Maggie Pierce, who reveals herself to be his secret daughter with Ellis Grey.|
|Name||Actor/actress||Starring seasons||Recurring seasons||Occupation at Grey Sloan
(or its predecessors)
|Theodora "Teddy" Altman||Kim Raver||6, 7, 8, 15||6, 14||Chief of Cardiothoracic Surgery, Attending Cardiothoracic Surgeon||M.D., FACS|
|Teddy Altman takes over the job of Chief of Cardiothoracic Surgery at Seattle Grace Mercy West Hospital in Season 6. She previously served in Iraq with Owen Hunt. Although a skilled surgeon, her teaching methods might appear somewhat unorthodox. Her arrival at Seattle Grace, followed by her confession of love to Owen, causes some friction between Owen and his girlfriend, Cristina Yang. In Season 8, Teddy marries Henry, a patient at the hospital, so he can get insurance, and they eventually fall in love. Their romance tragically ends when Henry dies while Cristina performs surgery on him. Over time, a friendship develops between Teddy and Cristina, but Teddy's friendship with Owen ends when she feels he puts the hospital before her. When Owen finds out Teddy was offered a job at the U.S. Army Medical Command (MEDCOM) but turned it down because she wanted to be there for Owen, Owen fires her so she will go to MEDCOM. Teddy returns in Season 14 to be there for Owen after his sister, Megan, is found. Towards the end of Season 14, it is revealed that Teddy is pregnant after sleeping with Owen. In Season 15, she moves back to Seattle.|
|Jackson Avery||Jesse Williams||7, 8, 9, 10, 11, 12, 13, 14, 15||6||Chief of Plastic Surgery, Attending Plastic Surgeon, Attending E.N.T. Surgeon, Chairman of the Board, Trustee to the Harper Avery Foundation||M.D., FACS|
|First introduced as a surgical resident from Mercy West Hospital after the merger, Jackson Avery is a grandson of the famous surgeon Dr. Harper Avery and son of the renowned surgeon Dr. Catherine Fox Avery. A member of the "plastics posse", training under Mark Sloan (and succeeding him as Chief of Plastics following his death), he is also called "pretty boy," especially by Cristina Yang. He develops a crush on Cristina and, while inebriated at a party, he kisses her, but Cristina breaks the kiss. He also has a complicated relationship with Lexie Grey, which becomes a recurring plot point. Though he was offered a position as surgical fellow at Tulane Medical Center, Jackson decides to stay in Seattle following Mark Sloan's death. At the end of Season 8, he starts sleeping with his best friend April Kepner, who had previously planned to remain a virgin until marriage. After Jackson and April break up, Jackson starts a relationship with the new intern, Stephanie Edwards, after hooking up in a car during Bailey's wedding. April goes on to date a paramedic named Matthew Taylor. At April's wedding to Matthew, Jackson realizes he still loves April and stands up professing his love; they soon after elope. It is then revealed that he and April are expecting a baby, but they learn early on that their unborn son has a fatal condition. April gives birth to their stillborn son, whom they name Samuel. Jackson and April experience marital problems, leading to their separation. However, after sleeping together one night, April gets pregnant and eventually gives birth to their healthy daughter, Harriet. Now divorced from April, Jackson is in a relationship with Maggie Pierce.|
|Preston Burke||Isaiah Washington||1, 2, 3||10||Chief of Cardiothoracic surgery, Attending Cardiothoracic Surgeon||M.D., FACS|
|Preston Burke is the former Chief of Cardiothoracic Surgery, and was once expected to become Chief of Surgery. He begins a romantic relationship with Cristina Yang, which comes under strain when Burke is shot and his right hand's nerve supply is disrupted. With his career threatened, he has Cristina perform some of his surgeries, a situation which is resolved when Dr. Shepherd repairs his right hand's nerve supply. Burke and Cristina continue their relationship, which ultimately ends on their wedding day, when he leaves her at the altar and leaves the hospital. Burke graduated at the top of his class from the Johns Hopkins School of Medicine. In Season 4, he receives the Harper Avery Award. Burke returns in Season 10, offering Cristina his hospital in Zurich, which she takes.|
|Meredith Grey||Ellen Pompeo||1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15||N/A||Chief of General Surgery, Attending General Surgeon, Director of the Board, Grey Sloan Shareholder||M.D., FACS|
|Meredith Grey is the central protagonist of the show and narrator of the majority of episodes. She begins the series as an intern and has since progressed along her medical career path. She went to the Geisel School of Medicine at Dartmouth College after sleeping around Europe with her former best friend, Sadie. She is best friends with Cristina Yang. Following a long romance, she marries neurosurgeon Derek Shepherd. The day of the shooting in Season 6, she discovers that she is pregnant, but that same day, she miscarriages due to stress. She later learns that she has a "hostile uterus" and starts taking fertility shots. When they are unsuccessful, Meredith and Derek adopt Zola, a surgical African orphan. In Season 9, following the plane crash that killed her younger sister, Lexie Grey, Meredith becomes an attending general surgeon and has earned the nickname of "Medusa" by her interns and residents. Her son, Bailey, is born in the Season 9 finale; she gives birth to him by C-section and has a major abdominal surgery afterwards following a fall. In the Season 10 finale, she says goodbye to Cristina as Cristina leaves to go to Zurich to take Burke's hospital; before they say goodbye, Cristina reminds Meredith that she should not let Derek's career hinder her own. In Season 11, Meredith not only struggles with keeping her marriage afloat after Derek decides to work for the president in DC, but also with learning that she has another half-sister, Maggie Pierce. After Derek is killed at the end of Season 11, Meredith escapes to California for a year, where she gives birth to their daughter, whom she names Ellis after her late mother. In Season 12, Meredith returns to Seattle and is named Chief of General Surgery by the newly appointed Chief of Surgery, Miranda Bailey. Meredith tries moving on by dating William Thorpe, a surgeon from another hospital, but has trouble forgetting about Derek. She is finally able to take the next step with Nathan Riggs, and the two begin a relationship after months of Nathan pursuing Meredith, but the romance comes to an end after Nathan's missing fiancée, Megan, is found. Meredith wins a Harper Avery Award in Season 14 after performing a ground-breaking abdominal wall transplant on Megan.|
|Erica Hahn||Brooke Smith||4, 5||2, 3||Chief of Cardiothoracic surgery, Attending Cardiothoracic Surgeon||M.D., FACS|
|Following Preston Burke's departure, Erica Hahn takes his position as Chief of Cardiothoracic Surgery at Seattle Grace. Her brusque, somewhat harsh personality is tempered by Callie Torres, with whom she begins a relationship. Her time at Seattle Grace ends abruptly, however, when she becomes discontent with Izzie Stevens, and the lack of disciplinary action following the Denny Duquette incident. Dr. Hahn attended the Johns Hopkins School of Medicine, where she was in the same class as Dr. Burke.|
|Atticus "Link" Lincoln||Chris Carmack||N/A||15||Chief of Orthopedic Surgery, Attending Orthopedic Surgeon||M.D.|
|New character for season 15|
|Addison Montgomery||Kate Walsh||2, 3||1, 2||Chief of Neonatal Surgery, Obstetrics, and Gynaecology, Attending Neonatal Surgeon, Attending Obstetrician-Gynaecologist, Attending Fetal Surgeon, Attending Medical Geneticist||M.D., FACS, FACOG|
|Former Chief of OB/GYN and Neonatal Surgery and the ex-wife of Derek Shepherd, Addison Montgomery transfers to Seattle Grace seeking reconciliation with Derek. After achieving a degree of understanding with Derek, and realizing that he is in love with Meredith Grey, Addison leaves Seattle Grace. The character went on to be the protagonist of Grey's Anatomy spinoff, Private Practice for six seasons and sporadically made guest appearances on Grey's until her last one in Season 8.|
|Margaret "Maggie" Pierce||Kelly McCreary||11, 12, 13, 14, 15||10||Chief of Cardiothoracic Surgery, Attending Cardiothoracic Surgeon||M.D., FACS|
|Maggie Pierce enters at the end of the Season 10 as the new Chief of Cardiothoracic Surgery. She shares with Richard Webber, her birth father, that her biological mother is Ellis Grey. At the beginning of Season 11, Maggie informs Meredith that they are sisters; although Meredith is hostile towards Maggie about the situation, she eventually welcomes her into the family. After Derek dies, Maggie moves in with Meredith, along with Meredith's sister-in-law, Amelia Shepherd. Maggie begins a relationship with Andrew DeLuca, an intern at Grey Sloan, but that ends in the middle of Season 12; she then moves her interest to Nathan Riggs, but he is unavailable due to his budding romance with Meredith. In Season 14, Maggie begins to date Jackson Avery.|
|Arizona Robbins||Jessica Capshaw||6, 7, 8, 9, 10, 11, 12, 13, 14||5||Chief of Pediatric Surgery, Chief of Fetal Surgery, Attending Pediatric Surgeon, Attending Fetal Surgeon, Director of the Board, Grey Sloan Shareholder||M.D., FACS|
|Arizona Robbins, pediatric surgery attending, has a cheery disposition but gets upset when challenging authority. Upon her introduction in Season 5, Arizona immediately embarks upon a relationship with Callie Torres. She comes from a military family and graduated from the Johns Hopkins School of Medicine. Arizona harbors great emotional intelligence. Her insight and advice have been used to defuse several situations, such as Callie's dispute with her father. In Season 7, Arizona wins a prestigious award, and she and Callie plan to move to Malawi, and work there. However, she breaks up with Callie and leaves her at the airport. They reconcile soon after and ultimately get married right after their daughter, Sofia, is born. In the Season 9 premiere, she has lost one of her legs due to injuries sustained during a plane crash at the end of Season 8, which results in a strained relationship with her wife, culminating in her ultimately cheating on Callie. They are briefly separated but ultimately decide to work things out. However, after going through a thirty-day hiatus during couples therapy, Callie decides to end things between the two of them. At the end of Season 12, Arizona gets full custody of Sofia following a messy custody battle, but she decides to allow Sofia to go back and forth between parents when Callie moves to New York. In Season 13, Arizona begins a relationship with Eliza Minnick, an intrusive doctor whom everyone dislikes, and is forced to hide their relationship for some time. However, by the beginning of Season 14, Eliza has left Seattle, and Arizona starts seeing visiting doctor, Carina DeLuca. When Sofia starts having disciplinary problems in school, Arizona decides it's best that she moves herself and Sofia to New York City to be with Callie; as a result, Arizona and Carina break up. During the Season 14 finale, Arizona and Sofia leave for New York, with the possibility of Arizona reconciling her relationship with Callie.|
|Amelia Shepherd||Caterina Scorsone||11, 12, 13, 14, 15||10||Chief of Neurosurgery, Attending Neurosurgeon||M.D., FACS|
|Amelia Shepherd is one of Derek Shepherd's many sisters. Like her brother, she is also a neurosurgeon. Amelia and Derek immediately don't have the best relationship due to Amelia's past history with substance abuse and the inevitable competition within their same career field, but they eventually learn to work together, even when Amelia takes Derek's long-held position as Chief of Neurosurgery. After Derek's death in Season 11, Amelia moves in with her sister-in-law, Meredith Grey, although they initially have some unresolved issues about Derek to work out. Amelia marries Owen Hunt in the Season 12 finale, but their marriage is rocky and ultimately culminates in a divorce at the beginning of Season 14. Amelia discovers that she has a tumor that has been affecting her judgement for the last 10 years; she gets it removed by her former Johns Hopkins University professor Tom Koracick, whom she starts sleeping with. Towards the end of the season, Amelia takes in a homeless teenage girl who had just given up her baby, whom Owen is fostering.|
|Mark Sloan||Eric Dane||3, 4, 5, 6, 7, 8, 9*||2, 3||Chief of Plastic Surgery, Attending Plastic Surgeon, Attending E.N.T Surgeon||M.D., FACS|
|Mark Sloan, Chief of Plastic Surgery, attended Columbia University College of Physicians and Surgeons. He has a playboy personality that jeopardizes his friendship with Derek Shepherd when he has an affair with Derek's wife, Addison Montgomery. He has known both Derek and Addison from the time when all three lived in New York City. Derek and Mark manage to resolve their issues and reaffirm their friendship. He has been given the nickname "McSteamy" by Meredith and her friends. Sloan has a relationship with Lexie Grey, which ends due to the strain of Mark's 18-year-old daughter from a one-night stand appearing at the hospital and subsequently moving in with them. Mark's daughter comes to him, pregnant, and though he wants her to keep the baby, she doesn't. Afterward she leaves Seattle, Mark and Lexie resume their relationship, but it ends when Mark gets Callie Torres pregnant, and Lexie starts dating Jackson Avery. When Lexie is dying after the plane crash, Mark admits that he loves her and always will; he holds her hand until she dies. In the Season 9 premiere, Mark dies from injuries sustained in a plane crash. The hospital is renamed in his memory and Lexie's memory.|
|Calliope "Callie" Torres||Sara Ramirez||3, 4, 5, 6, 7, 8, 9, 10, 11, 12||2||Chief of Orthopedic Surgery, Attending Orthopedic Surgeon, Director of the Board, Grey Sloan Shareholder||M.D., FACS|
|Callie Torres, an orthopedic surgeon, is introduced as an orthopedic surgical resident. She was once married to George O'Malley but divorced him after he has an affair Izzie Stevens. Later, she has a fling with Erica Hahn, but that is cut short by Hahn's departure from Seattle Grace. Callie then enters into a happy relationship with Arizona Robbins, but they break up because Arizona does not want to have kids. At the end of Season 6, after performing surgery on a small girl while a shooter is loose in the hospital, Callie tells Arizona in a roundabout way that she loves her. The two get back together and decide that they are going to have children. In Season 7, Callie is going to move to Africa with Arizona, but Arizona breaks up with her and leaves her at the airport in Seattle. Callie sleeps with Mark again and becomes pregnant. Arizona later returns for Callie, and they get back together. Later, Callie is severely injured in a car crash with Arizona. Addison delivers her baby, Sofia Robbin Sloan Torres, at 23 weeks, and the baby survives; soon after, she and Arizona marry. In the Season 9 premiere, the relationship between Callie and Arizona is strained with Mark dying and Arizona having one leg amputated, as decided by Callie to save Arizona's life. Still resenting Callie's medical decision, Arizona cheats on her, leading Callie to kick her out of the apartment. After the Travis Reed lawsuit and a conversation with her father, Callie asked Arizona to move back in and they began working on repairing their marriage. Callie cuts their couples therapy short when she realizes that she needs to love herself, not Arizona. In the Season 12 finale, she resigns from Grey-Sloan and moves to New York City with her girlfriend, Penny, following a messy custody battle over Sofia.|
- Although he only appeared in the first two episodes of the ninth season, Eric Dane was still billed as a member of the main cast in those two episodes.
|Name||Actor/actress||Starring seasons||Recurring seasons||Occupation at Grey Sloan
(or its predecessors)
|April Kepner||Sarah Drew||7, 8, 9, 10, 11, 12, 13, 14||6||Attending Trauma Surgeon||M.D., FACS|
|First introduced as a surgical resident from Mercy West Hospital during the merger, April Kepner is fired by Richard Webber in Season 6 due to a mistake she made that cost a patient her life. She is later rehired by Derek Shepherd during his run as Chief because he believes her dismissal was unfair, and she eventually develops a crush on him, despite his marriage to Meredith Grey. In the Season 6 finale, she tells him that her best friend, Reed Adamson, has been shot and killed. She later runs into Mr. Clark (the shooter) when Derek is shot. Clark lets her go when she emotionally tells him everything about her life. Although April becomes Chief Resident in the Season 7 finale, she fails to pass her Medical Boards and is later fired from Seattle Grace; however, she asked to come back by Owen Hunt because of her strong work ethic, and she later passes her boards. At her wedding to EMT Matthew Taylor, her best friend and former fling, Jackson Avery, realizes he still loves April and stands up, professing his love. Jackson and April run off and elope; soon after, it is discovered that April is pregnant. However, Jackson and April learn that their unborn baby has a fatal condition, and April is forced to give birth to their stillborn son, Samuel, which causes tension between her and Jackson. Although they get divorced in Season 12, April gives birth to their daughter, Harriet, in the Season 12 finale after they have a one-night stand. In Season 14, April has a crisis of faith following the death of a patient but eventually rediscovers her connection with God. Weeks later, she gets into a car accident, and while she is recovering, it is revealed that she has been seeing Matthew Taylor for the last few months. In the Season 14 finale, April has quit her job at the hospital to do charity work and spontaneously weds Matthew, marking her character's last appearance on the show.|
|Nathan Riggs||Martin Henderson||12, 13, 14*||N/A||Attending Cardiothoracic Surgeon||M.D., FACS|
|Nathan is introduced in Season 12 as Owen Hunt's old friend from the army. Though they used to be best friends, Owen is not happy with Nathan's appearance, and it is later revealed that the cause of their feud is that Owen blames Nathan for his sister, Megan's, disappearance almost 10 years ago. Nathan and Megan were engaged, but Nathan had cheated on her in the days leading up to her kidnapping. Still, Nathan works hard at Grey Sloan Memorial as an attending cardiothoracic surgeon, where he works under Maggie Pierce. Eventually, Owen and Nathan make up, just as Nathan spontaneously sleeps with Meredith Grey in the back of her car. After they sleep together, Nathan realizes his feelings for Meredith, as they both bond over the loss of a loved one, and continuously pursues her. Though Meredith resists his advances for some time after finding out that Maggie likes him, she eventually gives in and sleeps with him during a hectic plane ride, thus beginning their relationship. They date for some time until Megan is found. Nathan and Megan try to resume their relationship, but it struggles to take off when Megan believes that Nathan is still in love with Meredith. Still, with Meredith's pushing, Nathan brings home Megan's son, Farouk, from Iraq, showing that he truly loves Megan. Nathan departs from Grey Sloan Memorial after he, Megan, and Farouk move to Los Angeles to restart their lives.|
|Benjamin "Ben" Warren||Jason George||12, 13, 14||6, 7, 8, 9, 10, 11||Attending Anesthesiologist, General Surgical Resident||M.D.|
|Ben Warren is introduced as an anesthesiologist from Mercy West Hospital in Season 6. He also becomes boyfriend of Miranda Bailey until she breaks up with him after the shooting, finding herself unable to be in a relationship after such a traumatic experience. Ben tries to stay away from Miranda, but they eventually start working together again, though she has begun a relationship with a nurse named Eli. However, she eventually ends things with Eli and reunites with Ben. He proposes to Miranda during Season 8, and she accepts. After they get married, Ben gets the chance to become a surgical intern in California. He accepts, much to Bailey's distress. He eventually returns as a surgical resident at Grey Sloan. When talking to Shepherd about his fears for Bailey developing OCD, he realizes he inadvertently reported her, thus straining their marriage. Still, they get through it until Ben decides to change careers for the third time when he wants to become a fireman. This angers Bailey, as she believes he is throwing away the chance to be a great surgeon, but they eventually reconcile.|
- Although he only appeared in the first five episodes of the fourteenth season, Martin Henderson was still billed as a member of the main cast in those five episodes.
|Name||Actor/actress||Starring seasons||Recurring seasons||Occupation at Grey Sloan
(or its predecessors)
|Josephine "Jo" Karev||Camilla Luddington||10, 11, 12, 13, 14, 15||9||Surgical Innovation Fellow||M.D.|
|An intern on Season 9, Jo Wilson is at first made fun of by Alex Karev, who believes she's a rich girl and nicknames her "princess." On the contrary, she had a cruel childhood and has had to work very hard in order to get through life and become a doctor. Alex gradually warms up to her, and they become close friends. She starts a relationship with an obstetrician, causing Alex to become jealous. She is set to move in with her boyfriend, but they get in a physical fight in which he becomes severely injured. After she leaves her boyfriend, Alex confesses his love to Jo. They start dating but have relationship issues in Season 11 when she turns down Alex's marriage proposal. Things only worsen when Alex beats up Andrew DeLuca after finding him and Jo in a compromising situation, landing Alex in jail for a brief period. Jo has trust issues with Alex, as she believes he could physically hurt her, but she forgives him once she discovers that Alex had tracked down her ex-husband, Paul, but didn't beat him up. In Season 14, Paul comes to Grey Sloan to sign divorce papers from Jo, whom he calls "Brooke", since she changed her name and ran away when they separated. Paul is still the same manipulative and abusive husband that he was years ago, and that scares Jo into signing the papers. Paul threatens Jo's life, but he is soon after killed during a hit-and-run, freeing Jo of her past. In the Season 14 finale, Alex and Jo get married.|
|Nico Kim||Alex Landi||N/A||15||Orthopedic Surgical Fellow||M.D.|
|New character for season 15|
|Cristina Yang||Sandra Oh||1, 2, 3, 4, 5, 6, 7, 8, 9, 10||N/A||Cardiothoracic Surgical Fellow, Director of the Board, Grey Sloan Share Holder||M.D., Ph.D.|
|Cristina Yang attained a Ph.D. in biochemistry from the University of California, Berkeley and an M.D. from Stanford University School of Medicine. A skilled resident, Cristina has an indomitable passion for cardiothoracic surgery and is almost ruthless in pursuit of her specialty. She is best friends with Meredith Grey and is in a relationship with Preston Burke,until he leaves Cristina on their wedding day. Time later, she enters a relationship with Owen Hunt, whom she marries in Season 7. At the beginning of Season 9, following the plane crash, she leaves Seattle and works as a cardiothoracic surgical fellow at the Mayo Clinic in Rochester, Minnesota. Like Meredith, she is unable to board a plane due to the plane crash trauma, so they barely see each other. However, Cristina returns to Seattle after Craig Thomas, her cardiothoracic attending and best friend at the Mayo Clinic, dies while performing a surgery. In Season 10, Meredith and Cristina have a falling out due to their different values in life and career paths. Cristina believes that she is more advanced in career because Meredith chose to have a marriage and kids, and Cristina's argument is only strengthened when she is nominated for a Harper Avery award. However, she loses due to the hospital's connection with the Avery family. Yang meets Burke again, and he offers her his job in Zurich. When Cristina leaves, she has an emotional goodbye with Meredith, and she leaves with Shane to go to Zurich.|
|Name||Actor/actress||Starring seasons||Recurring seasons||Occupation at Grey Sloan
(or its predecessors)
|Andrew DeLuca||Giacomo Gianniotti||12, 13, 14, 15||11||General Surgical Resident||M.D.|
|Andrew DeLuca was an EMT before he decided to switch to being a surgical intern in Season 12. Soon after his internship begins, he starts a relationship with Maggie Pierce, but that ultimately ends when he doesn't have feelings for her anymore. In Season 14, his ex-girlfriend, Sam Bello, joins Grey Sloan, and they resume their relationship briefly before she leaves the hospital to avoid deportation.|
|Stephanie Edwards||Jerrika Hinton||10 , 11, 12, 13||9||General Surgical Resident||M.D.|
|An intern on Season 9, Stephanie Edwards is similar to Cristina Yang, as she has high hopes for her surgical career. Despite this, she starts dating Jackson Avery after he breaks up with April Kepner, although they break up when Jackson stops April's wedding by professing his love for her. Stephanie then dates a patient, Kyle, but they break up in the days leading up to his death, leaving an emotional impact on her. She leaves at the end of Season 13 following a fire at the hospital to live life outside of a hospital, which she hasn't known since she spent her childhood in hospitals sick.|
|Alexandra "Lexie" Grey||Chyler Leigh||4, 5, 6, 7, 8||3||General Surgical Resident||M.D.|
|Resident and half-sister of Meredith Grey, Lexie Grey attended Harvard Medical School. She has had relationships with Mark Sloan, Alex Karev, and Jackson Avery. Known for her photographic memory, she has earned the nickname "Lexipedia." Initially she has a distant, contentious relationship with Meredith, but they eventually grow closer. She is often called "Little Grey" by other doctors on staff. In Season 8, she professes her love for Mark, but he does not tell her he loves her back until the plane crash. She dies from her injuries while holding onto Mark.|
|Leah Murphy||Tessa Ferrer||10||9, 13||General Surgical Resident||M.D.|
|An intern on Season 9, Leah Murphy briefly sleeps with Alex Karev, who is having sex with intern after intern at the time. She often asks her fellow interns questions related to Alex and seems to be hung up on him. She has an affair with Arizona Robbins while Arizona and Callie Torres were separated. However, when Arizona ends their tryst to repair her marriage, Leah becomes hung up on her and hopes for their marriage to end, going as to report her and Arizona's relationship to the hospital. In Season 10, Leah is told by chief Webber that surgery is not for her, and that she should leave the program.|
|George O'Malley||T.R. Knight||1, 2, 3, 4, 5||N/A||General Surgical Resident||M.D.|
|George O'Malley has a less aggressive personality compared to his fellow residents. He has an infatuation with Meredith Grey, which ends when they sleep together and, halfway through, Meredith begins to cry and ultimately rejects him. He has a strong friendship with Izzie Stevens and, later, Lexie Grey. He was once married to Callie Torres, but their marriage came to an end when George slept with Izzie. George and Izzie attempt to have a relationship but decide to remain friends when they realize that their relationship lacks chemistry. Inspired by Owen Hunt's experiences, George decides to leave Seattle Grace and enlist in the Army. Tragically, on his way to tell his mother about joining the Army, George dies when he prevents a girl from being hit by a bus, sacrificing himself instead.|
|Shane Ross||Gaius Charles||10||9||General Surgical Resident||M.D.|
|An intern on Season 9, Shane Ross aims to be "the new Shepherd" and even assists on Derek's hand surgery. However, he is frustrated when Derek chooses Heather Brooks as his intern because of her quick reflexes. In Season 10, after he sticks up for Cristina Yang when she and Meredith fight over the 3D printer, he and Yang start a sexual relationship, which only lasts briefly. Later in the season, Ross almost kills a patient, as sleep deprivation causes him to have a mental break down. In the Season 10 finale, Ross leaves Seattle for Zurich with Cristina, as he wants to learn from her.|
|Isobel "Izzie" Stevens||Katherine Heigl||1, 2, 3, 4, 5, 6||N/A||General Surgical Resident||M.D.|
|After growing up in a trailer park and putting her newborn daughter up for adoption at age 16, Izzie Stevens managed to advance through medical school by modeling to pay her bills. She puts her career as doctor on the line in a risky bid to get her fiancé, Denny Duquette, a new heart by cutting his LVAD wires. Denny subsequently dies, but Izzie manages to keep her job following invasive therapy sessions put up by the hospital. She then begins a relationship with Alex Karev, and they eventually get married. Their relationship becomes strained when she is diagnosed with metastatic melanoma. She recovers following treatment with Interleukin 2 but after, returning to work, she accidentally induces hyperkalemia in a patient listed for a renal transplant. Subsequently, she loses her job and leaves Seattle. She and Alex divorce, and she is never seen again.|
The following listings reflect each character's status at the time of his or her first appearance on staff at Seattle Grace/Seattle Grace Mercy West/Grey Sloan Memorial.
|Dr. Virginia Dixon||Mary McDonnell||5||3|
|An exceptional cardiothoracic surgeon who has Asperger syndrome, Dr. Dixon serves as the interim Head of Cardiothoracic Surgery in Season 5.|
|Dr. Rebecca Swender||Kimberly Elise||5||3|
|A surgical oncology attending assigned to oversee Izzie Stevens' cancer treatment, Dr. Swender is said to be the best surgical oncologist in the state of Washington. She is a proponent for IL-2-use as treatment for cancer, citing its success when a patient, initially given only three months to live, uses the therapy and survives an additional two years. The patient, however, succumbs to complications from the inherent nature of the IL-2, which affects Swender's otherwise authoritarian and impartial persona, and casts doubt on this treatment-protocol.|
|Dr. Margaret Campbell||Faye Dunaway||5||1|
|A general surgery attending, Dr. Campbell is Seattle Grace's first female surgeon. With 40 years of surgical experience, she is considered a pioneer and one of the hospital's most respected surgeons. Richard Webber may have been taught by her, which is implied when she recalls an incident involving a clamp dropped into an open body cavity. She has worked with Ellis Grey. Cristina Yang has been vocal about her objections and criticisms of Dr. Campbell's continued long-standing service. Due to a complication caused by a lacerated bowel during a routine cholecystectomy, Dr. Campbell retires after performing her last surgery to repair the "careless mistake."|
|Dr. Robert Stark||Peter MacNicol||7||7|
|An incompetent pediatric surgery attending, Dr. Stark is brought in as the interim Chief of Pediatric Surgery when Arizona Robbins gives her notice to oversee a pediatric surgery program in Malawi, Africa. Under contract for a year, Dr. Stark continues to serve as the department chief when Robbins returns. Described as a lazy doctor and a complacent and self-satisfied attending, he represents the antithesis of attending surgeons commonly employed at Seattle Grace/Mercy West Hospital. Dr. Stark has an antagonistic disposition with most of the hospital staff, especially Alex Karev. April Kepner is the only exception to his behavior. He later attempts to date her, with little success.|
|Dr. Lucy Fields||Rachael Taylor||7||8|
|An OB/GYN attending and maternal-fetal medicine fellow at Seattle Grace Mercy West, Dr. Fields is self-proclaimed "damn good at her job." She attended Harvard Medical School and completed her OB/GYN residency at Duke University Medical Center. Dr. Fields is Callie Torres' obstetrician and shows that she is equal parts tough, ironic, and empathetic, especially when dealing with Torres and her support team: Mark Sloan and Arizona Robbins. She seems to have a slight crush on Alex Karev, and they begin to form a relationship. Dr. Addison Montgomery returns and is told that she is not able to deal with traumatic pregnancy cases (such as a pregnant Callie involved in a car accident). Alex Karev breaks off his relationship with Dr. Fields in the Season 7 finale, and she goes off to treat children in Africa.|
|Dr. Nicole Herman||Geena Davis||11, 14||14|
|Nicole Herman is introduced as the Head of Fetal Surgery at Grey Sloan Memorial Hospital. Arizona works with her as a fellow to switch from Pediatric Surgery to Fetal Surgery. It is then revealed that Herman has an inoperable brain tumor and only has 6 months left to live; as a result, she decide she wants to use this period of time to teach Arizona about Fetal Surgery since it is a new field. When Amelia informs Herman that she believes she could remove the tumor, Herman initially rejects the idea until deciding it's what's best. Amelia operates and, despite some complications, successfully removes Herman's tumor. However, Herman doesn't wake up for several days after the surgery, leading Amelia to look for a cause. An MRI shows signs of a stroke, and when Herman finally wakes up, though she is fully aware of her surroundings and shows no loss of mental faculties, she becomes completely blind. After being discharged from the hospital, Herman goes to the Blind Institute, where she learns to live her daily life as a blind person. In Season 14, Herman returns to the hospital in fear that her tumor has returned, but it turns out just to be a cyst. Herman then offers Arizona an extraordinary opportunity to start the Robbins-Herman Center for Women's Health, which they will institute in New York City.|
|Dr. Sydney Heron||Kali Rocha||2, 3, 4||8|
|A fifth-year general surgery resident at Seattle Grace, Dr. Heron is known for her extremely perky personality. She initially appears as Miranda's substitute when Miranda is on maternity leave. She clashes with Cristina, who finds Sydney's positive attitude unbearable. She later serves as Izzie's peer counselor and reveals that her perky persona actually originates from a nervous breakdown she had after losing a patient of her own. Sydney is in the running to become chief resident, but loses to Callie, who is later replaced by Miranda. Sydney goes on one date with Dr. Shepherd, but dumps him when she decides he isn't ready for the kind of relationship she needs.|
|Dr. Reed Adamson||Nora Zehetner||6||10|
|Surgical resident, formerly at Mercy West Hospital, Dr. Adamson is close friends with Dr. Charles Percy and Dr. April Kepner. She seems to be attracted to Alex Karev, and has a one-night stand with Mark Sloan. She is shot in the head by Gary Clark in the Season Six finale.|
|Dr. Charles Percy||Robert Baker||6, 8, 12||13|
|Surgical resident, formerly at Mercy West Hospital, Dr. Percy is often referred to as "the big guy." He is in love with Dr. Reed Adamson. Percy is shot by Gary Clark in the Season Six finale and, despite Miranda Bailey's efforts, he dies. He reprises his role in Season 8 in "If/Then" and later in Season 12 in "Unbreak My Heart".|
|Dr. Steve Mostow||Mark Saul||4, 5, 6, 7, 8||38|
|Dr. Mostow is a surgical intern of Dr. Cristina Yang, who calls him "2". In "There's no 'I' in Team," Dr. Yang considered "giving" him to George O'Malley when he finally passes his medical exams. Steve allows the other interns to practice an epidural anesthesia on him and introduce a catheter into his male organs. As a result, he cannot move for a while and is not present at Sadie's operation. Dr. Yang finds him immobilized and finds out about the operation, after which Steve is put on probation, along with the other interns. Steve later sleeps with fellow intern Pierce's girlfriend Megan, and she gets pregnant. Steve and Megan get married, and he is concluded to be the father. During the merger, Megan is fired, but Steve keeps his job, although Megan is later hired back by Derek Shepherd. According to his blog, he has aspirations to go into neurosurgery as a specialty.|
|Dr. Graciela Guzman||Gloria Garayua||4, 5, 6||17|
|Dr. Guzman is a surgical intern of Dr. Izzie Stevens, who considers giving her to George O'Malley because she "charts like crap," but keeps her because she can put in a line. Graciela is a nervous student, who eats a lot of chocolate when she's nervous. In the episode "In The Midnight Hour," she is the only one who quits the interns' operation on Sadie because she feels it's wrong. Nevertheless, she is put on probation with the other interns.|
|Intern Pierce||Joseph Williamson||4, 5, 6||23|
|Pierce is a surgical intern of Dr. Alex Karev, who considers giving him to George O'Malley just because Dr. Karev hates how his name sounds. Pierce has confronted Dr. Karev on at least one occasion, such as when he meets his punishment along with the other interns in the episode "In The Midnight Hour" and comments that Dr. Stevens killed a man and was forgiven. Dr. Karev responds by physically attacking him. Later in the season, Pierce and Steve fight over Megan, Pierce's girlfriend, who slept with Steve during a breakup. She is now pregnant without knowing who the father of her baby is.|
|Dr. Ryan Spalding||Brandon Scott||5, 6||15|
|A surgical intern of Dr. Cristina Yang, who considers giving him to George O'Malley, Dr. Spalding first appears in the episode "Life During Wartime" and is subsequently named "4.2". In the episode "In The Midnight Hour," Ryan is one of the surgical interns operating on Dr. Sadie Harris. He is left on his own in an OR, while the others go to get help. He is put on probation with the other interns after Sadie nearly dies in the operation.|
|Dr. Megan Mostow||Molly Kidder||4, 5, 6||25|
|Dr. Megan Mostow (nee Nowland) is a resident and former intern of Dr. Meredith Grey, who considers giving her to George O'Malley. She has a relationship with Intern Pierce, which ends when she has an affair with Steve that results in a pregnancy. During the hospital merger, the Chief fires her by e-mail, and she later decides to sue the hospital, believing her dismissal is related to her pregnancy. She is later rehired by Derek Shepherd, who believes she was fired unjustly and deserves a "fighting chance."|
|Intern Laura||Candice Afia||4, 5, 6||25|
|A former surgical intern under Dr. Alex Karev, Laura is rebuked by Izzie Stevens when she makes fun of a patient with a facial deformity.|
|Dr. Sadie Harris||Melissa George||5||8|
|An intern and former best friend of Meredith, Sadie has self-harm tendencies and later quits Seattle Grace after her medical knowledge and expertise are called into question.|
|Dr. Norman Shales||Edward Herrmann||4||3|
|An elderly surgical intern assigned to second-year Dr. Alex Karev, Dr. Shales is a former pharmacist who, because of his age, is often mistaken by patients for the senior physician. He has since transferred into psychiatry.|
|Dr. Heather Brooks||Tina Majorino||9, 10||22|
|An intern on Season 9, Dr. Brooks briefly sleeps with Dr. Alex Karev, who is having sex with intern after intern at the time. Her quick reflexes contribute to her being picked by Dr. Derek Shepherd to receive lessons in the neurosurgical field. Heather dies from complications in Season 10 premiere after being electrocuted while trying to find Dr. Richard Webber. She finds him in a pool of water and she steps onto the water before realizing that it was "live", she falls and hits her head. After she's found, Dr. Derek Shepherd and Dr. Shane Ross operate and manage to evacuate her subdural hematoma, but her brain swells and she dies due to raised intracranial pressure.|
|Dr. Levi Schmitt||Jake Borelli||14, 15||18|
|A new intern introduced in Season 14, Dr. Schmitt is widely known as the guy whose glasses fell on a patient during surgery. He has a one-night stand with Dr. Jo Wilson, but his relationship with her ends when she gets back together with Dr. Alex Karev. Dr. Schmitt begins his intern year worried about his tainted reputation, but his mentor, Dr. Meredith Grey, assures him that people don't think of him like that.|
|Dr. Sam Bello||Jeanine Mason||14||12|
|A Season 14 new intern who, upon attending the new intern mixer the night before her first day, discovers that her ex-boyfriend, Dr. Andrew DeLuca, also works at Grey-Sloan Memorial. Despite their best efforts to avoid falling back into their toxic, on-again, off-again relationship, Sam and Andrew ultimately being sleeping together again. In the Season 14 episode "Beautiful Dreamer," Sam is put at risk of getting deported back to El Salvador by ICE because she had run a red light. To save Sam's medical career and avoid deportation, Dr. Meredith Grey sends Sam to continue her residency at Dr. Cristina Yang's hospital in Zurich.|
|Dr. Casey Parker||Alex Blue Davis||14, 15||13|
|Another new intern in Season 14 who also has great skill in computer hacking. His abilities come in handy when an anonymous hacker breaks into the Grey Sloan computer system and shuts down all electricity and data, causing chaos among doctors and patients; Parker is able to shut this down by hacking the person back. It is then that he reveals to Dr. Miranda Bailey that he first used his computer skills to change his gender on his license, as the DMV wouldn't change it when Parker completed his transition.|
|Dr. Vikram Roy||Rushi Kota||14, 15||14|
|A Season 14 intern who is cocky and very confident in his surgical skills. Despite this, he is no better than any of his peers and shows not to hold his head well under intense pressure. During Dr. April Kepner's faith crisis, she begins sleeping with Roy, but that eventually ends when she rediscovers herself. In the Season 14 episode "Judgement Day," Roy is fired by Dr. Richard Webber after he tries to operate under the influence of cannabis. Roy tries to sue for wrongful termination, and Dr. Miranda Bailey eventually re-employs him under the agreement that he will be monitored closely by her for the next year.|
|Dr. Taryn Helm||Jaicy Elliot||14, 15||17|
|A new intern introduced in Season 14. She becomes good friends with another intern, Dr. Levi Schmitt, and is often involved in his embarrassing actions. Helm becomes infatuated with Dr. Meredith Grey and, during Jo and Alex's wedding, she gets drunk and almost tells Dr. Grey that she's in love with her.|
|Dr. Dahlia Qadri||Sophia Taylor Ali||14, 15||12|
|A Season 14 new intern who is proud of her religion and shows it in her headpiece. She is attracted to Dr. Jackson Avery, and when she has the chance to work on his service, stumbles on her words in front of him.|
|Nurse Olivia Harper||Sarah Utterback||1, 2, 3, 4, 6, 14||19|
|A nurse at the hospital, Olivia has relationships with George and Alex. Alex gives her syphilis, which she then unknowingly gives to George after breaking up with Alex (part of a hospital-wide syphilis epidemic among the doctors and nurses). Alex begins a relationship with Izzie, who finds him cheating on her with Olivia. The female interns sometimes insultingly refer to her as "Syph Nurse." She is a member of the club "Nurses United Against Mark Sloan," which implies she has had sexual relations with him. During the merger, she is fired and Derek offers to give her a recommendation. Olivia returns in the Season 14 episode, "Bad Reputation," after her son is admitted to the hospital; she runs into Alex but still isn't very fond of him.|
|Nurse Tyler Christian||Moe Irvin||1, 2, 3, 4, 5, 6, 7, 10||26|
|Nurse Tyler is one of the members of the nursing staff at Seattle Grace. He attends the nurse strike in Season 2.|
|Patricia||Robin Pearson Rose||1, 2, 3, 5||12|
|Patricia is Richard Weber's assistant/secretary and previously worked as a nurse.|
|Nurse Rose||Lauren Stamile||4, 5||12|
|A nurse at the hospital, she works often with Dr. Derek Shepherd. Rose has been the attending nurse on 36 of Dr. Shepherd's surgeries (as she announced in "Forever Young," Season 4, Episode 8). Derek and Rose share a kiss and are dating, much to Meredith's distress as she tries to get over him. Despite their seemingly happy relationship, Rose is soon bothered by comments made by hospital personnel about Meredith and Derek's breakup being only temporary (which end up being true when Derek and Meredith get back together for good). Addison Montgomery sarcastically calls Rose "McRebound," unaware that Rose is in the room. Her prediction proves correct when, in the season finale "Freedom," Derek and Meredith make up and kiss. Derek abruptly leaves this kiss to break up with Rose, signaling the end of their relationship. Afterward, Rose is hostile towards Derek whenever she sees him but, when she accidentally cuts his hand during a surgery, she apologizes and transfers to peds.|
Other hospital physicians
|Dr. Katharine Wyatt||Amy Madigan||4, 5, 6||18|
|A psychiatrist at the hospital, Katharine is Dr. Meredith Grey's and Dr. Erica Hahn's therapist. As of the episode "Sweet Surrender," Dr. Owen Hunt has begun sessions with her.|
|Dr. Raj Sen||Anjul Nigam||1, 2, 4||7|
|A psychiatric resident at Seattle Grace, Dr. Sen sometimes provides consults for the surgeons.|
|Dr. Finn Dandridge||Chris O'Donnell||2, 3||9|
|The former veterinarian of Meredith and Derek's dog, Doc, Finn is also the newest love interest of Meredith for some time. Meredith breaks up with him because she is still in love with Derek. Finn's wife, Liz, died in a car accident. The interns give him the nickname "McVet," along the same form as Derek Shepherd's nickname, McDreamy. He dates Meredith throughout the end of the second season, and the beginning of the third season. He competes with Derek Shepherd for Meredith's heart and ultimately loses to Derek because Meredith is still in love with Derek. Meredith realizes that he may be the "best guy," but he isn't "her guy." After she tells him this, he replies, "He'll break your heart again, Meredith, and when he does, I won't be here" and walks out for the last time.|
|Dr. Colin Marlowe||Roger Rees||3||3|
|A professor at Stanford University and a brilliant cardiothoracic surgeon noted for pioneering a procedure called the Marlowe transplant, Colin Marlowe had a three-year relationship with Cristina Yang before she graduated and began her residency at Seattle Grace. He appears months later as a candidate for Chief of Surgery, and ultimately withdraws when his true purpose for joining the staff at Seattle Grace, to rekindle his relationship with Cristina, fails.|
|Dr. William "Will" Thorpe||Scott Elrod||12||4|
|A surgical oncologist at Bauer Army Medical Center, William Thorpe works on Brian Carson with Dr. Meredith Grey, Dr. Callie Torres, Dr. Jackson Avery, and Dr. Jo Wilson. After the surgery is complete, Thorpe flirts with Meredith, and the two exchange numbers. Afraid to move on from Derek, Meredith dodges Thorpe's calls until he shows up to pursue her outside of Grey-Sloan Memorial. Meredith agrees to get drinks with him but freaks out again and cancels. Thorpe shows up in the lobby after Meredith's 17-hour surgery and takes her home, where they talk and eat in his car. After three dates, the two sleep together, but the next morning, Meredith feels like she cheated on Derek and kicks Thorpe out. Worried about Meredith, Thorpe visits her that night, where she admits that he is the first guy she has dated since Derek died and that she's just not ready to move on. Thorpe says he will wait for Meredith because she is worth waiting for.|
Meredith Grey's family
- Ellis Grey (Kate Burton, Sarah Paulson–1982 flashback, Sally Pressman- 1983 flashbacks): Meredith's mother and Maggie's biological mother, a highly respected surgeon who trained at Seattle Grace with Dr. Webber. During their residency, she and Webber had an affair. She left her husband Thatcher for Dr. Webber, but he could not bring himself to leave his wife. After her residency, she left Seattle to take a position at Mass General. She also worked at the Mayo Clinic. She has won the Harper Avery Award twice, and she invented the laparoscopic Grey method. She developed early-onset Alzheimer's shortly before Meredith started medical school and, at the start of the show, she has been placed in Roseridge Home for Extended Care, a nursing home. She dies of cardiac arrest in the middle of Season 3. In the episode "Drowning on Dry Land," she appears to her daughter Meredith, encouraging her to go back and live her life. She also appears in an alternate-reality episode from Season 8, called "If/then." In series 11 "She's Leaving Home", Meredith gives birth to a baby daughter, whom she names after her mother. In Season 14 episode "Who Lives, Who Dies, Who Tells Your Story", she appears in an OR Gallery as an image applauding Meredith as she wins her first Harper Avery Award.
- Thatcher Grey (Jeff Perry): Father of Meredith Grey and Lexie Grey. He was married to Ellis Grey, Meredith's mother, for about seven years. They divorced after she had an affair with Richard Webber. Thatcher blames Ellis somewhat for his estrangement from Meredith, saying Ellis is "cold" and won't let him get to know his daughter. After the disintegration of his first family, Thatcher remained in Seattle and married his second wife, Susan. They had two daughters, Lexie and Molly. After Meredith moves to Seattle for her residency, Susan encourages Thatcher and Meredith to develop a relationship. However, Susan's sudden death devastates Thatcher, and he blames her death on Meredith. He becomes an alcoholic, and Lexie has to give up a residency at Massachusetts General Hospital to move to Seattle to care for her father. He eventually enters rehab and apologizes to his daughters. However, his alcoholism has destroyed his liver, and Meredith has to give him a portion of hers to save his life. It is revealed in season 15 that he has not spoken to Meredith since Lexie died and is currently dying of Acute myeloid leukaemia.
- Susan Grey (Mare Winningham) Meredith's stepmother who dies of the hiccups
- Molly Grey-Thompson (Mandy Siegfried): Daughter of Thatcher and Susan Grey, Meredith's half-sister. She proposes to her husband, Eric, before he is shipped out by the military to be stationed in Iraq. Originally a patient at Mercy West, Molly transfers to Seattle Grace when she is 32 weeks pregnant and Addison operates to repair a congenital diaphragmatic hernia in Molly's baby. She later gives birth to a daughter, whom she names Laura.
- Lexie Grey Meredith Grey's half sister. Daughter of Thatcher and Susan Grey. She and Meredith have a rocky relationship at the start but become close and the show progressed. She and Mark Sloan are in a long term relationship before they are killed in a plane crash.
- Laura Thompson: Daughter of Molly Grey and Eric Thompson and Lexie's niece and Meredith's half-niece. She is born premature and kept at Seattle Grace Hospital several weeks after her birth, prompting her grandfather Thatcher Grey to hang around.
- Margaret "Maggie" Pierce: Daughter of Ellis Grey and Richard Webber. Meredith's half-sister. Born in Boston, after Ellis and Meredith moved there, leaving Thatcher in Seattle, she was given up for adoption. She becomes a skilled heart surgeon and eventually moves to Seattle, becoming Chief of Cardio at Grey Sloan Memorial Hospital after Cristina Yang leaves.
- Derek Shepherd (Patrick Dempsey): Meredith's husband since Season 5, legally since Season 7. Originally married to Addison Montgomery, they divorced in the third season. Derek is the father of Zola Grey Shepherd, Derek Bailey Shepherd and Ellis Shepherd. In season 11 episode 21 "How To Save A Life", he dies of a head injury after his car was T-Boned by a semi.
- Zola Grey Shepherd: Daughter of Meredith and Derek, who is brought over with the children from Africa under the direction of Karev in Season 7. She has a spinal disease, but is treated by Derek with a shunt. They later adopt her.
- Derek Bailey Shepherd: Son of Meredith and Derek, delivered via C-section because he is not in the correct position. While stitching Meredith up, the obstetrician who operates on Meredith is called away to another patient and an intern completes the stitching. When she begins bleeding from everywhere, Meredith diagnoses herself as in DIC. Miranda performs a spleen removal, which saves Meredith's life. Derek and Meredith name their baby after Miranda Bailey.
- Ellis Shepherd: Second daughter of Meredith and Derek. She was born during the time jump that took place after Derek's funeral in "She's Leaving Home".
Lexie Grey's family
- Meredith Grey (Ellen Pompeo): The daughter of Thatcher Grey and Ellis Grey. Meredith is Lexie's older half-sister whom Lexie meets at the beginning of the fourth season. Although Meredith isn't initially fond of Lexie and does not wish to know her, Meredith eventually warms up to Lexie, and the two become extremely close until Lexie's death.
- Susan Grey (Mare Winningham): The second wife of Thatcher Grey, and mother of Lexie Grey and Molly Grey-Thompson. Susan was always aware of Thatcher's first wife and daughter, but she doesn't meet Meredith until Molly is a patient at Seattle Grace. She reaches out to Meredith and encourages her to develop a relationship with Thatcher. At first, Meredith resists Susan's attempts to mother her, but eventually comes to think of Susan as a surrogate mother. Susan dies suddenly, following a rare complication from a routine procedure to treat her acid reflux and hiccups. Thatcher is devastated by her death and became an alcoholic.
- Thatcher Grey (Jeff Perry): Father of Meredith Grey and Lexie Grey. He was married to Ellis Grey, Meredith's mother, for about seven years. They divorced after she had an affair with Richard Webber. Thatcher blames Ellis somewhat for his estrangement from Meredith, saying Ellis is "cold" and won't let him get to know his daughter. After the disintegration of his first family, Thatcher remained in Seattle and married his second wife, Susan. They had two daughters, Lexie and Molly. After Meredith moves to Seattle for her residency, Susan encourages Thatcher and Meredith to develop a relationship. However, Susan's sudden death devastates Thatcher, and he blames her death on Meredith. He becomes an alcoholic, and Lexie has to give up a residency at Massachusetts General Hospital to move to Seattle to care for her father. He eventually enters rehab and apologizes to his daughters. However, his alcoholism has destroyed his liver, and Meredith has to give him a portion of hers to save his life.
- Molly Grey-Thompson (Mandy Siegfried): Daughter of Thatcher and Susan Grey, Lexie's younger sister and Meredith's half-sister. She proposes to her husband, Eric, before he is shipped out by the military to be stationed in Iraq. Originally a patient at Mercy West, Molly transfers to Seattle Grace when she is 32 weeks pregnant and Addison operates to repair a congenital diaphragmatic hernia in Molly's baby. She later gives birth to a daughter, whom she names Laura.
- Laura Thompson: Daughter of Molly Grey and Eric Thompson and Lexie's niece and Meredith's half-niece. She is born premature and kept at Seattle Grace Hospital several weeks after her birth, prompting her grandfather Thatcher Grey to hang around. Niece of Alexandra (Lexie) Grey.
- Zola Grey Shepherd: Daughter of Meredith and Derek and half-niece's of Lexie, who is brought over with the children from Africa under the direction of Karev in Season 7. She has a spinal disease, but is treated by Derek with a shunt. They later adopt her. She is the half-niece of Alexandra (Lexie) Grey.
- Derek Bailey Shepherd: Son of Meredith and Derek, delivered via C-section because he is not in the correct position. While stitching Meredith up, the obstetrician who operates on Meredith is called away to another patient and an intern completes the stitching. When she begins bleeding from everywhere, Meredith diagnoses herself as in DIC. Miranda performs a spleen removal, which saves Meredith's life. Derek and Meredith name their baby after Miranda Bailey. He is the half-nephew of Alexandra (Lexie) Grey, although never met by Lexie as she dies before Bailey is born.
- Ellis Shepherd: Second daughter of Meredith and Derek and Lexie's half-niece. She was born during the time jump that took place after Derek's funeral in "She's Leaving Home". She is the half-niece of Alexandra (Lexie) Grey although Lexie never meets Ellis as she dies before the baby is born.
Derek Shepherd's family
- Meredith Grey (Ellen Pompeo): Derek's second wife until season 11 episode 21 "How To Save A Life", when he dies of a head injury after his car is T-Boned by a semi. She is the mother of Zola, Bailey and Ellis.
- Addison Montgomery (Kate Walsh): Derek's first wife who cheated on him with Mark. She comes to Seattle at Richard's request and the two attempt to reconcile. She ultimately moves to Los Angeles.
- Amelia Shepherd (Caterina Scorsone): Derek's sister and the youngest Shepherd child. She and Derek witnessed their father being murdered. She became addicted to prescription medication before crashing Derek's car while under the influence. Amelia worked with Addison in Los Angeles, and is her son's godmother. She has slept with Mark (as have Nancy and Addison before her). She is currently Chief of Neuro at Grey Sloan.
- Zola Grey Shepherd (Jela K. Moore, Heaven White): Daughter of Meredith and Derek, who is brought over with the children from Africa under the direction of Karev in Season 7. She has a spinal disease, but is treated by Derek with a shunt. They later adopt her.
- Derek Bailey Shepherd: Son of Meredith Grey and Derek Shepherd, delivered via C-section because he is not in the correct position. While stitching Meredith up, the obstetrician who operates on Meredith is called away to another patient and an intern completes the stitching. When she begins bleeding from everywhere, Meredith diagnoses herself as in DIC. Miranda performs a spleen removal, which saves Meredith's life. Derek and Meredith name their baby after Miranda Bailey.
- Ellis Shepherd: Second daughter of Meredith and Derek, born 9 months after Derek's death.
- Carolyn Maloney-Shepherd (Tyne Daly): Derek's mother, who cared for Derek and his sisters after her husband was murdered.
- Kathleen Shepherd: One of Derek's sisters; she has only been mentioned in passing and has not appeared on the show. Derek mentions she is a therapist.
- Liz Shepherd (Neve Campbell): One of Derek's sisters. After the nerves in Derek's hand are damaged in a plane crash, she donates a nerve in her leg in order to repair his hand. Like her siblings she is a doctor though her specialty is unknown and though it is unlikely that she is a psychiatrist or a neurosurgeon.
- Nancy Shepherd (Embeth Davidtz): One of Derek's sisters. She slept with Mark (as revealed in the episode "Let The Angels Commit"). She tells her brother, "Come on Derek. Everyone sleeps with Mark." She dislikes Meredith, and admires Addison possibly due to them both being OB/GYN doctors.
- Alexandra "Lexie" Grey (Chyler Leigh): Becomes Derek's half sister-in-law when he and Meredith Grey marry. Lexie later dies in the plane crash in the season 8 finale titled 'Flight'.
- Margaret "Maggie" Pierce Becomes Derek's half-sister-in-law when he and Meredith Grey marry.
Cristina Yang's family
- Helen Yang Rubenstein (Tsai Chin): Cristina's mother. Helen and Cristina's father divorced (Cristina watched her father die as they were both in a car accident), and she remarried Dr. Saul Rubenstein, an oral surgeon, when Cristina was three. She thinks Cristina should focus more on getting married and less on her career.
Izzie Stevens's family
- Hannah Klein (Liv Hutchings): Izzie's biological daughter, born when Izzie was 16 years old. In the third season, Hannah is admitted to Seattle Grace Hospital with leukemia, and Izzie donates bone marrow to her. However, Hannah refuses to see her.
- Robbie Stevens (Sharon Lawrence): Izzie's mother, who now works as a waitress.
- Denny Duquette Jr. Jeffrey Dean Morgan: Izzie's fiancé for a short period of time before he died of a stroke after receiving a heart transplant. In his will he leaves Izzie $8,700,000, with which she opens the "Denny Duquette Memorial Clinic" that provides free health check ups to patients.
Richard Webber's family
- Camille Travis (Tessa Thompson / Camille Winbush): Adele's niece, daughter of Adele's sister Arlene. She was diagnosed with ovarian cancer when she was 14, and the cancer returns when she is a senior in high school. Dr. Bailey orders the interns to plan a prom in the hospital for her.
- Arlene Travis (Shelley Robertson): Adele's sister and Camille's mother.
- Adele Webber (Loretta Devine): Dr. Webber's wife. Frequently frustrated by his devotion to the hospital, she eventually leaves him. She becomes pregnant with his child, but has a miscarriage. They have since reconciled. She has recently been diagnosed with Alzheimer's disease. She dies of a heart attack in the Season 9 winter premiere.
- Catherine Avery (Debbie Allen): Richard'second wife whom he marries in season 11.
- Margaret "Maggie" Pierce biological daughter with Ellis Grey.
George O'Malley's family
- Harold O'Malley (George Dzundza): Father of George O'Malley, he was a truck driver with a passion for vintage cars. He was married for 40 years to his wife, Louise, and they had three sons: Jerry, Ronny, and George. He is very proud of all of his sons, but he often has trouble relating to George. He is admitted to Seattle Grace with esophageal cancer that has spread to his stomach, as well as a leaking aortic valve. He undergoes surgery to successfully replace the valve, and later has a second surgery to determine the extent of the cancer. Prior to the second surgery, he asks Dr. Webber and Dr. Bailey to remove the tumor regardless of the risk, in order to give him a chance to fight the cancer. The surgery proves too much for his body and, after several days, he goes into multi-system organ failure, which prompts the family to remove him from life support.
- Jerry O'Malley (Greg Pitts): George's brother, who works at a dry cleaners.
- Louise O'Malley (Debra Monk): George's mother, who works as a teacher. George seems to find her a little overbearing, and is often embarrassed by her good-natured gestures, such as setting out breakfast for the interns during rounds, and offering to iron his scrubs. She is a devout Catholic, and she is very upset when George and Callie get divorced.
- Ronny O'Malley (Tim Griffin): George's brother, who works at the post office.
- Callie Torres (Sara Ramirez): George's ex-wife. They get married in Las Vegas in Season 3, and later divorce in Season 4 because George is in love with Izzie.
Alex Karev's family
- Jo Karev (Camilla Luddington): Alex's wife, a Surgical Innovation Fellow who works at Grey Sloan Memorial Hospital.
- Jimmy Evans (James Remar): Alex's father, a heroin addict, who was often absent during his childhood. He used to beat Alex and Aaron, while Amber was too young during that time to recall Jimmy's behavior to her brothers. It's still unexplained how he disappeared from Alex's life, but assuming that Alex's mother died due to an illness and Alex, Aaron and Amber going through foster homes, he just left. Because of how Jimmy beat up Alex's mother, Alex became a wrestler to defend his mother. In season ten, he returns unknowingly into Alex's life, due to being brought to Grey Sloan Hospital for treatment. By then, it has been revealed that he was living as a struggling musician. After arriving in an ambulance, he asks Alex for something, which causes Alex to realize the patient might be his father. Though Alex does not want to know the result of a DNA-match suggested by Jo Wilson, she reveals the results anyway, which confirms that Jimmy is Alex's father. Alex begins secretly visiting the bar where his father starts playing after recovering and during one visit, Jimmy and Alex talk of childhood and regrets. Because Jimmy had taught Alex how to play guitar as a child, Alex assumes the discussion is about him and is goaded into playing a tune that brings memories back to Jimmy. When Alex learns that Jimmy is talking about Nicky, his son by another woman, Alex angrily beats his father up. Jimmy fails to understand Alex's anger when the latter tells Jimmy never to return to Nicky and his mother until after Alex leaves and Jimmy realizes that Alex is his son. During Jimmy's attempts to go clean, he winds up in the hospital from through withdrawal. Jo has to take care over him, which causes strain in her and Alex's relationship.
- Aaron Karev (Jake McLaughlin): Alex's younger brother, who works as a mover. He is very nice and polite, which is why Cristina names him "Angel Spawn," while she calls Alex "Evil Spawn". He comes to Seattle Grace with a hernia, which Dr. Bailey successfully repairs. He's very chatty and tells the doctors about his and Alex's troubled childhood. He is later diagnosed with schizophrenia after he has a psychotic break and tries to kill his younger sister, Amber. As a result, he has been committed to a psychiatric ward.
- Amber Karev: Alex's younger sister, a high school student. Aaron is trying to convince her to go to college, but she doesn't see the point.
- Nicky Evans: Alex's younger paternal half-brother. It's assumed he still lives with his mother in South Florida.
- Helen Karev (Lindsay Wagner): Alex's mother. Helen was diagnosed with a mental disorder but has recovered enough to resume her job at her local library. Alex and Jo visit her in Iowa in the season 14 episode 22 "Fight For Your Mind".
Miranda Bailey's family
- Tucker Jones (Cress Williams): Miranda's ex-husband, who divorces her because she spends more time working than at home with him and Tuck. Tucker is operated on by Derek when he is involved in a car accident on his way to the hospital for their son's birth.
- William George "Tuck" Bailey Jones: Miranda's son with her ex-husband Tucker.
- Ben Warren (Jason George): Miranda's current husband, whom she marries in Season 9.
Mark Sloan's family
- Grandson: Mark's grandson through Sloan, who gave him up for adoption.
- Sloan Riley (Leven Rambin): Mark's biological daughter. As an 18-year-old, she gives birth to Mark's grandson and puts him up for adoption.
- Sofia Robbin Sloan Torres: Mark's daughter with Callie Torres and Arizona Robbins. Conceived after Mark and Callie begin several trysts after Callie is left in the airport by Arizona Robbins, she is born prematurely on March 31, 2011, in the "Song Beneath the Song" episode.
Teddy Altman's family
- Henry Burton (Scott Foley): Husband of Dr. Teddy Altman. She meets and marries him in Season 7 so that he can use her health insurance to cover the ongoing costs of his treatment for Von Hippel-Lindau disease. They eventually fall in love. He dies in Season 8 while undergoing surgery.
Callie Torres's family
- Uncle Berto: Callie's uncle, whom she assumes might be gay, saying, "he hasn't been single for 60 years for no reason."
- George O'Malley (T. R. Knight): Callie's ex-husband. They got married in Las Vegas in Season 3, and later divorced in Season 4 because George is in love with Izzie. George dies in Season 5.
- Arizona Robbins (Jessica Capshaw): Callie's ex-wife. A pediatric surgery attending, Arizona comes from a military family.
- Aria Torres: Callie's sister, only mentioned on the show.
- Carlos Torres (Hector Elizondo): Father to Dr. Callie Torres. He originally is against his daughter's homosexuality and relationship with Dr. Arizona Robbins.
- Lucia Torres (Gina Gallego): Mother to Dr. Callie Torres. She has problems with accepting her daughter's sexuality and refuses to attend her wedding to Arizona Robbins.
- Sofia Robbin Sloan Torres: Callie's daughter, born prematurely on March 31, 2011, in the "Song Beneath the Song" episode. She is conceived after Mark and Callie begin several trysts when Callie is left in the airport by Arizona Robbins.
Arizona Robbins's family
- Barbara Robbins (Judith Ivey): Arizona's mother.
- Colonel Daniel Robbins, United States Marine Corps (Denis Arndt): Arizona's father.
- Timothy Robbins: Arizona's brother, who died in the Iraq war.
- Callie Torres (Sara Ramirez): Arizona's ex-wife and attending orthopedic surgeon at Grey Sloan Memorial Hospital.
- Sofia Robbin Sloan Torres: Arizona's daughter, born prematurely on March 31, 2011, in the "Song Beneath the Song" episode. She is conceived after Mark and Callie begin several trysts when Callie is left in the airport by Arizona. Arizona now has sole custody of Sofia due to a family court ruling in season 12.
Jackson Avery's family
- Dr. April Kepner: Avery's ex-wife and Trauma surgeon at Grey Sloan Memorial Hospital. April and Jackson elope, after Jackson confesses his feelings for April at the altar during her wedding to Paramedic Matthew Taylor. They have had an on and off again relationship and built in sexual tension, since Jackson took April's virginity before their Board Exam. April failed and blamed Jackson for Jesus punishing her for having sex before marriage.
- Samuel Norbert Avery: Avery and Kepner's late son born at 24 weeks, due to type II osteogenesis imperfecta. He was baptized before dying soon after in parent's arms.
- Harriet Kepner-Avery: Avery and Kepner's daughter. Was conceived during a moment of passion between April and Jackson in the midst of their fighting. Things aren't patched up after their one night tryst and they decided to divorce. Before signing the divorce papers, April discovered she was pregnant. Overjoyed that she could still conceive, she decided to keep the pregnancy secret out of fear that something is wrong like her last pregnancy. After a while, Arizona Robbins discovers that April is pregnant and urges her to tell Jackson and when April doesn't do it, Arizona does it herself. Jackson is at first angry but comes to understand it and they agree to raise her as co-parents. Harriet was born during a caesarean section with April under no anesthesia because April was in Meredith's kitchen and there was no way to go to the hospital. Soon Catherine comes to accept April as a mother and since Jackson and April decided to give Harriet both of their last surnames, Catherine is finally happy to see the Avery name kept alive. She was named after the famous Harriet Tubman.
- Dr. Catherine Avery (née Fox) (Debbie Allen): Avery's mother and a brilliant urological surgeon. She appears at Seattle Grace Mercy West to perform the "first" penis transplant in the U.S. She proctors the boards in San Francisco, where she also has a one-night tryst with Dr. Webber. She and Dr. Webber eventually begin a relationship and are now married.
- Dr. Harper Avery: Grandfather of Jackson Avery and a world-renowned surgeon.
- Marla Sokoloff as Glenda Castillo (2015)
- Neve Campbell as Lizzie Shepherd (2012)
- Summer Glau as Emily Kovach (2012)
- James Avery as Sam (2012)
- Nia Vardalos as Karen (2012)
- Demi Lovato as Hayley May (2010)
- Paola Andino as Lily Price (2010)
- Mandy Moore as Mary Portman (2010)
- Vanessa Martinez as Gretchen Price (2010)
- Ryan Devlin as Bill Portman (2010)
- Jennifer Westfeldt as Jen Harmon (2009)
- Faye Dunaway as Dr. Margaret Campbell (2009)
- Bernadette Peters as Sarabeth Breyers (2008)
- Seth Green as Nick Hanscom (2007)
- Maggie Siff as Ruthie Sales (2007)
- Bellamy Young as Kathy (2007)
- John Cho as Dr. Marshall Stone (2006)
- Laurie Metcalf as Beatrice Carter (2006)
- Christina Ricci as Hannah Davies (2006)
- Joe the Bartender (Steven W. Bailey): The owner of the Emerald City Bar, located across from the hospital, where the doctors often go for a drink. Joe collapses due to an aneurysm in the episode "Raindrops Keep Falling on my Head," and Derek and Burke perform a stand-still surgery to repair it. Joe and his boyfriend Walter attend the Thanksgiving dinner Izzie hosts at Meredith's house, and they go on a camping trip with Dr. Shepherd, Preston, Richard, Alex and George. During the trip, Joe reveals during a discussion with the Chief that, although he and Walter have been "on-and-off" for about 10 years, they are now committed and considering the possibility of children. They are one of two couples being considered as adoptive parents for a young mother's twins.
- Walter (Jack Yang): Joe's boyfriend.
- Bonnie Crasnoff (Monica Keena): A patient admitted to Seattle Grace Hospital after being involved a train crash, she and another passenger, Tom, are connected by a large metal pole passing through their bodies. Since moving the pole would kill them, the doctors decide to move one of the patients off the pole, then operate around the pole to repair the damage in the other patient. Since her injuries are more severe, they decide to move her, and she dies almost immediately. Bonnie reappears in Season 3 as part of Meredith's dream after drowning.
- Dennison "Denny" Duquette, Jr. (Jeffrey Dean Morgan): A patient waiting for a heart transplant, he develops a close relationship with Izzie, and eventually proposes to her. Izzie risks her career to save him by cutting his LVAD wire, ensuring that he will become so ill that he will get a new heart. He dies from a blood clot shortly after the transplant, but reappears in Season Three as part of Meredith's dream after she nearly drowns, and again in Season Five. Izzie begins to see Denny everywhere, which is eventually revealed to be a symptom of her brain tumor. He first appears in the Season Two episode "Begin the Begin," and makes his last appearance in the Season Five episode "Here's to Future Days".
- Dylan Young (Kyle Chandler): The commanding officer of the Seattle Police Department bomb squad, he responds to the bomb scare and helps to keep Meredith calm as she holds the bomb located inside a patient's body. She removes the bomb safely from the patient, but it explodes while Dylan carries it out of the OR. He reappears in Season 3 as part of Meredith's dream after her near-drowning.
- Amanda (Shannon Lucio): A young woman saved from being hit by a bus by George, who was himself subsequently dragged several yards by the bus and dies. Amanda is extremely concerned about him, and she stays with him in the ICU, referring to him as "her prince." She attends George's funeral and cries harder than his own mother. Amanda keeps a daily vigil outside the hospital until Izzie confronts her, pointing out that she is still alive thanks to George, and that she should honor him by living her life.
- Rebecca Pope or "Ava" (Elizabeth Reaser): A patient with amnesia after being badly injured in the ferry crash, she is discovered by Dr. Alex Karev, and they develop a very close relationship. While at Seattle Grace, she delivers a baby girl and undergoes extensive facial reconstruction surgery, performed by Dr. Mark Sloan. She eventually regains her memory and returns home with her husband, Jeff. However, before leaving, she pleads with Alex to "give [her] a reason to stay." She returns six weeks later, claiming to be pregnant with Alex's child. Although initially upset, Alex eventually becomes excited about having a baby with her. However, she is found to have a false pregnancy. When she attempts suicide, Izzie intervenes and has her admitted to the psychiatric ward. Elizabeth Reaser was nominated for the Outstanding Guest Actress in a Drama Series at the 59th Primetime Emmy Awards, for her role on the show.
- Gary Clark (Michael O'Neill): Husband of a patient at Seattle Grace, his wife is treated by Dr. Lexie Grey and Dr. Webber. After surgery, his wife goes into a coma and, since she has earlier signed a DNR, she is removed from life support. Clark files a lawsuit against Dr. Shepherd for wrongful death, but loses. In the Season 6 finale, he returns to the hospital intending to kill Dr. Shepherd, Dr. Lexie Grey, and Dr. Webber. He shoots several people, including Derek Shepherd, Owen Hunt, Reed Adamson, Charles Percy, and Alex Karev. After a tense standoff with Dr. Webber, he uses his last bullet to commit suicide instead of killing Dr. Webber.
- Mary Portman (Mandy Moore): Miranda Bailey's patient during the Seattle Grace shooting, she is the wife of Bill Portman. She helps Miranda attempt to save the life of Charles Percy and, despite their efforts, he dies. She returns to the hospital six months later to have the colostomy reversal she was supposed to have had the day of the shooting. Although the surgery is successful, Mary never wakes up. She is removed from life support one month later and dies.
- Bill Portman (Ryan Devlin): Husband of Mary Portman.
- "Exclusive: 'Grey's Anatomy' promotes Sarah Drew". Entertainment Weekly. Time Inc. June 9, 2010. Retrieved June 9, 2010.
- "Stand By Me". Grey's Anatomy. Season 5. Episode 16. 2009-03-19. ABC.
- "Here's to the Future". Grey's Anatomy. Season 5. Episode 23. 2009-05-14. ABC.
- "An Honest Mistake". Grey's Anatomy. Season 5. Episode 16. 2009-02-19. ABC.
- Clack, Zoanne. "Grey Matter: From the Writer's of Grey's Anatomy". Archived from the original on November 22, 2010. Retrieved February 5, 2011.
- Harper, Bill. "Grey Matter: From the Writer's of Grey's Anatomy". Archived from the original on November 17, 2010. Retrieved February 5, 2011.
- Mark Wilding (writer), Kevin McKidd (director) (February 3, 2011). "Don't Deceive Me (Please Don't Go)". Grey's Anatomy. Season 7. Episode 13. ABC.
- Wilding, Bill. "Grey Matter: From the Writer's of Grey's Anatomy". Archived from the original on February 18, 2011. Retrieved February 5, 2011.
- "The Intern Formerly Known as Steve". ABC.com. 2008. Archived from the original on February 8, 2009. Retrieved April 26, 2009.