ICI-199,441

ICI-199,441
Identifiers
	IUPAC name 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide;
CAS Number	115199-84-3 ;
PubChem CID	3082718;
ChEMBL	ChEMBL38576 ;
CompTox Dashboard (EPA)	DTXSID101029523 DTXSID60921646, DTXSID101029523 ;
Chemical and physical data
Formula	C21H24Cl2N2O
Molar mass	391.333 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1Cl)CC(=O)N(C)C(c3ccccc3)CN2CCCC2;
	(what is this?) (verify)

ICI-199,441 is a drug which acts as a potent and selective κ-opioid agonist, and has analgesic effects.^[1]^[2] It is a biased agonist of the KOR, and is one of a relatively few KOR ligands that is G protein-biased rather than β-arrestin-biased.[1]

References

^ Costello GF, Main BG, Barlow JJ, Carroll JA, Shaw JS (July 1988). "A novel series of potent and selective agonists at the opioid kappa-receptor". European Journal of Pharmacology. 151 (3): 475–8. doi:10.1016/0014-2999(88)90546-8. PMID 2850924.
^ Narita M, Kaneko C, Miyoshi K, Nagumo Y, Kuzumaki N, Nakajima M, Nanjo K, Matsuzawa K, Yamazaki M, Suzuki T (April 2006). "Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala". Neuropsychopharmacology. 31 (4): 739–50. doi:10.1038/sj.npp.1300858. PMID 16123756.

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