User talk:Lwollert

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Hi, Lwollert, welcome to WikiProject LGBT Studies!

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-- SatyrTN (talk | contribs) 16:32, 12 February 2007 (UTC)

Genetic level sex change, a possibility?[edit]

Originally from Talk:Transsexual, removed as it doesn't pertain to the article

Hi every1, i want to know something i guess that genetic medicine is not very advanced but, i was asking to myself something. Do u think that one of these days, a genetic sex reassignment theraphy can exist? i mean, do u think that scientists can develop a way to change all our genetical structure? that would be cool u know, because, even that it would be expensive, it would make of a transgender woman, a real woman (with possibilities of beign pregnant and that kind of stuff). My question is, if we use all our technology, do you think that kind of theraplhy would be a reality one of these days? — Preceding unsigned comment added by 189.192.18.232 (talkcontribs) 01:51, 14 February 2007 UTC

In reality, probably not for a LONG time.
Gene therapy has its limits, and does not necessarily mean the reconstruction of the body. It is certainly conceivable that therapy could be made to replace genetic material in a Y chromosome so that it acts as an X chromosome, however you need to remember that gene expression is not absolute; there is a phenomenon called penetrance to start with, and the hormonal and chemical status of a developing foetus has much to do with the end phenotype (how a person looks). Just look at the impact of Hormone replacement therapy - that is essentially turning on and off different gene expression in vivo. It would, however, be quite ironic; the VAST majority of a woman's second X chromasome is, in fact, inactive !!!! (See Barr body to see what it looks like in real life - btw, it's not all inactive, as women with only one X chromosome have Turner's syndrome and MOST women with two X chromosomes don not)
There are definitely ways to change our genetic structure; Epstein-Barr_Virus and HIV are both viruses that embed themselves into our DNA and change our genetic makeup forever. This is limited to certain cell lines, but the principle is there. (Any retrovirus will work by changing the DNA of the host cell permanently. --Puellanivis 08:07, 14 February 2007 (UTC))
In terms of giving a transsexual woman the ability to bear children, stem cell technologies are the way to go; You basically need a hollow organ with a blood supply (uterus) which has been achieved in the form of making a bladder; and you need to manage the early hormonal state of pregnancy (after a relatively short while, the placenta takes over the production of hormones). Of course, you still would need to produce an ovum from the transsexual woman, but there are already several technologies that could lead to that (such grabbing a spermatocyte during meiosis, and exchanging it's nucleus with that of a donated ova ovum; difficult, and with complications (such as the molar pregnancy)).
I would like to strongly point out, though, that even without this, Transsexual women identify as "real women" - just as some with intersex conditions identify as "real" women, despite similar (at least, post-GRS) anatomy.
Yes, I have researched this. I hope that it is in the future, but it is not likely in the current climate. I hope that helps.
P.S. if this is an issue you are going through, I recommend one of the many community sites and organizations set up to help transgendered and transsexual people - Cheers Lwollert 04:50, 14 February 2007 (UTC)
Please note that this is a talk page for improving the article itself, not for a general discussion of transsexualism. As noted above, many great online forums exist for discussing these issues. Thanks! Jokestress 05:04, 14 February 2007 (UTC)
From a wikipedia standpoint, such an action is unnecesary to be a "real woman", as mentioned above, Androgen insensitivty syndrome is where the karotype of an individual is XY, but their phenotype is female. There is a tendency to think that genetic distinction as XX would make us "real women", just like some people still believe that GRS will make them "real women". There's just no justification of that. Women who were raised as girls would still feel some separation from us as we were (most often) raised as boys, whether we shared exactly the same genetic material as them or not. Transsexual females will always be different from cisgender females, but that doesn't mean we're not "real", and being "real" isn't dependent upon how much or how little surgery/alteration we have. So basically, while this section may be an interesting tagent for some people while dreaming, it would provide no actual benefit to this article at all. Nothing short of changing history can make us identical to cisgender females. ... Oh, and sorry, but I just *have* to correct "Ova" to "Ovum", as the former is the plural of the latter, and the indefinite article "a/an" governs the singular. --Puellanivis 08:07, 14 February 2007 (UTC)
Along those same lines, I've heard/read a lot of comments from many transwomen who say "it takes more than a vagina to make a woman." Likewise, it takes more than a penis to make a man. Most cis-folk probably wouldn't agree with either statement (which is a large part of the problem), but I'd posit that it's extremely difficult to really understand trans-ness if you're not transgendered or transsexual. And even that isn't necessarily enough; as a transperson, sometimes I don't understand what it's all about either. <shrug> But as Jokestress says, this really isn't the place for this discussion. — Wwagner 16:41, 14 February 2007 (UTC)

ok, ok, thanks for that. i didn´t mean to offend any1 with my comment, it´s just that i am interested on that kind of technlogy and im also planning the sex change, ok? But anyways, thanks for clearing my doubts ppl. That´s why i luv wikipedia, u know, i find any kind of information i need, and i want to thank to all the ppl that has helped me on every doubt i have, really, thank u. :-)

No problem, but if you do identify as transsexual, I HIGHLY advise appropriate medical supervision from as early as possible; most clinics should understand if you are not prepared to transition immediately, but as pointed out above, non-cisgendered women and men have a LOT to work through - it's just not right for a girl to be brought up as a man (tongue-in-cheek, there). transsexuality, TS Roadmap, and Lynn Conway's Site are all useful resources, although the author of the last one is a little more controversial (at least according to TS Roadmap).
P.S. changed ova to ovum - thanks, I often muck that up.
P.P.S. to the unsigned poster we've been addressing, feel free to make an account and contribute!
P.P.P.S. As this discussion does not relate specifically to the article, it should be moved or deleted at some stage, probably soon. I'm happy to put it on my talk page for a bit, or are there other suggestions
Cheers, Lwollert 01:46, 15 February 2007 (UTC)
I was just thinking, that perhaps we could streamline it, get the important details and make it into a sort of sub-article that can then be placed on a person's User page. I kind of have something like that already on my user page with the "Hormone Therapy vs. Gilbert's Syndrome" entry.  :) --Puellanivis 02:38, 22 February 2007 (UTC)
Sounds interesting - I would certainly be interested in compiling the information - But it's mostly original research on my half so far, so do we run into wikipaedia rule issues? Or is it OKAY as a User's page?
BTW, In regards to your page, interestingly, I too have Gilbert's Syndrome, and am in the fairly rare (but thankfully not unique) position of being a final-year medical student (The medical training system over here (Australia) is quite different to over in America - basically, I know more general and much less specific knowledge than American graduates) as well as a Transwoman. I can say that the dose of estrogen you describe on your page is quite reasonable, and any higher you run into significant risks of Stroke, Deep Vein Thrombosis, and other similar medical conditions.
I can however, recommend adding progesterone in general for several reasons;
  1. Progesterone is a potent negative-feedback agent in the pituitary-gonadal axis; It helps block the production of testosterone quite effectively
  2. Because of the above, it may reduce the need for specific anti-androgens (such as spironolactone, which has significant "side effects" as well as complications - remember, its most common use is as a Diuretic.
  3. It allows the delivery of the hormones in a simple form - i.e. the Combined Oral Contraceptive Pill twice daily. An example is Ethinyoestrodiol 50mcg and Levornestregel 125 mcg.
As an alternative, look at Cyproterone Acetate, which although not approved by the FDA in america may still be available - It's a very potent anti-androgen
Don't forget, too, that ethinyloestradiol doesn't turn up on hormone assays - really the only useful test is Serum T - if that's in the female range, the hormones are doing their job. It takes time, patience, and a lot of frustration (from my limited experience, anyway.) I've also got a reference for a really good article from a year or two ago trying to get consensus on hormone treatment, I'll post it here when i get back from work tonight.
Cheers, Lwollert 00:29, 23 February 2007 (UTC)
I can´t believe this discussion moved so much people, whoa. Well, umm Lauren, i need to talk with you.check my youtube´s videos!!!!!!!!!!! just put raidentheninja on the search bar on youtube 23:31, 23 March 2007 (UTC)

LGBT WikiProject newsletter[edit]

DYK[edit]

Updated DYK query On 2 March, 2007, Did you know? was updated with a fact from the article Classification of transsexuals, which you created or substantially expanded. If you know of another interesting fact from a recently created article, then please suggest it on the "Did you know?" talk page.

--Yomanganitalk 13:43, 2 March 2007 (UTC)

Jumpaclass intersexuality[edit]

Lwollert, I can't justify upgrading the article from a stub. My apologies. Dev920 (Have a nice day!) 15:40, 4 March 2007 (UTC)

Not a problem - ended up not being able to edit it enough
Cheers Lwollert 09:07, 6 March 2007 (UTC)

LGBTI[edit]

You said "Intersex communities and LGBT communities have worked together in the past". Have you got background information on this that you could help me find? It's been a few years since I had my old course materials close at hand. coelacan — 10:14, 10 March 2007 (UTC)

Thanks, that's a start. coelacan — 10:28, 10 March 2007 (UTC)

Lauren, i need help[edit]

Hi Lauren, my name is Lindsay, and i´d like to ask you for some help. I consider myself as a transsexual but, i have some doubts, and i feel really confused about what is going on, i don´t even know if i can make it. I told my mom about my wish of being a girl a few weeks ago, but she got very devastated. I don´t even know what to do, and im not sure if i can make it, my mother is trying to wash my brain with stupid ideas, when i know what i really want, i really need help lauren, pleasee check my youtube´s videos!!!!!!!!!!! just put raidentheninja on the search bar on youtube 23:31, 23 March 2007 (UTC)

thanks for the help, but i have something else to say[edit]

Hi, it´s me again, thanks for the help, i just have one more question, how much money do you think i would need to have a complete reassignment? im talking about hormonal treatment, surgeries, breast augmentation, everyhting. and i have another question, what is the electrolysis for? isn´t supposed to be that the laser epilation is for that? what methods are the most used in the hair removal process? thanks for your help, and i hope i can survive to this, because i really want to make this dream to come true xoxo take care lauren, and hanks :-) check my youtube´s videos!!!!!!!!!!! just put raidentheninja on the search bar on youtube 00:56, 25 March 2007 (UTC)

thanks lauren[edit]

Thanks for all the things that you have told me, i really aprecciate it, i´d also like to say that i liked the way you talked to me. so i´d like to be your friend, because im gonna need some real support for this (at least someone who can listen ot me) I leave you my MSN and yahoo I hope we can talk again, take care, and once again, thanks for everything

Lindsay

check my youtube´s videos!!!!!!!!!!! just put raidentheninja on the search bar on youtube 01:22, 25 March 2007 (UTC)

LGBT WikiProject Newsletter[edit]

SatyrBot 05:13, 3 April 2007 (UTC)

Shemale[edit]

Hi, I recently helped with a discussion at this article regarding the nature of the word and came across your user subpage User:Lwollert/Shemale when doing a Google search. It looks like you have some good material that will help improve the article; I invite you to contribute to it. See you around, Sancho 04:24, 16 April 2007 (UTC)

Noticed your comment on Sanchom's talk page, especially the phrase 'a particular user who reverts any addition or modification to it.' [1] if that was an offhand slight against me I'm sorry you feel that way - for as you can see, I don't 'revert any and all modification' - quite the opposite, I didn't edit war, justified my views (as I did when last we edited that article) and it appears to have been improved by the attentions of this recent round of editors. I invite you to continue to make constructive edits and I ask you to continue to assume good faith. -- User:RyanFreisling @ 23:53, 16 April 2007 (UTC)
I have already stated my opinion, which is why i withdrew from the whole thing. Cheers! Lauren/ 06:09, 17 April 2007 (UTC)

Thanks![edit]

My first barnstar! It's been a few days, but thank you. Sancho 06:03, 19 April 2007 (UTC)

Shemale[edit]

Wikipedia:Articles for deletion/Shemale

Please take a look and comment. I bring this up due to the Shemale article currently stored in your userspace, which I feel could be employed to bring the Shemale article from a dictionary definition to a true article given the proper references. Hope to see you at the AFD. Cheers, LankybuggerYell ○ 03:19, 25 April 2007 (UTC)

As a side note, I believe your version of the article is superior to the version currently presented in the Shemale article, providing a larger scope for the term beyond a typical dictionary definition. Frankly, that User:RyanFreisling seems to have ignored the additional information presented seems silly. Cheers, LankybuggerYell ○ 03:30, 25 April 2007 (UTC)
Not silly, I just felt there was a lot more information there than was encyclopedic for the topic -that's my opinion. I didn't ignore or reject the majority of the content there, indeed much of it was present for months and months before Lwollert's edits and some of it I myself provided during the exchange with Lwollert. The ongoing attempt to remove or reduce the derogatory nature of the term to an 'aside' is what I saw (and see) as silly (and unencyclopedic). In any event, if the general sense of the community is to support this new version, I was and am happy to accept it as well. Honest thanks for your edits! -- User:RyanFreisling @ 03:52, 25 April 2007 (UTC)
People, I'm happy that you like the version, feel free to use it, I'm just not involved anymore. Cheers! Lauren/ 04:10, 25 April 2007 (UTC)

LGBT WikiProject newsletter[edit]

This month's project newsletter (hand delivered as SatyrTN and Dev920 are away). Best wishes, WjBscribe 03:47, 2 May 2007 (UTC)

Capitalisation[edit]

Due to the software used sex reassignment surgery points to Sex reassignment surgery, and is not a redirect. All titles have their first letter capitalised regardless of how they should be. Notable issues arise with iPod and eBay, which point to IPod and EBay respectively. More information is available at Wikipedia:Naming conventions (capitalization), if you're interested. Avoiding redirects is a helpful task, but one not required in this instance. If my undo seemed snippy, it's just because too many people use AGF as a weapon, rather contradicting the spirit of the principle. I don't know which you were meaning, but happy editing. --Limegreen 11:00, 7 May 2007 (UTC)

Ah. But you did also insert [[Sex reassignment surgery|sex reassignment surgery]](which is unnecessary). I assumed that your second edit was the same, at a speed glance... --Limegreen 04:45, 8 May 2007 (UTC)

GID and Chimerism[edit]

Originally from Talk:Gender identity disorder

Is it possible that Gender Identity Disorder is a manifestation of chimerism in humans? In human chimerism, two fertilized ova merge very early in pregnancy to form an individual with mixed genetic makeup, e.g., liver with one set of DNA and kidneys with another. It seems possible, for example, that such an individual could be formed with mostly female characteristics but with substituted (or added) male genitalia. If this were the case, treating the condition as a purely psychiatric disorder might not be wholly appropriate. —The preceding unsigned comment was added by Zbvhs (talkcontribs) 01:43, 29 April 2007 (UTC).

Note: You should also see Mosaicism. Chimerism is often used when it's two different species, but technically is just two different zygotes.
Everything is possible; however, all people who get hormone therapy have at least a hormone assay, and commonly a karyotype. This would pick up most mosaics or chimeras. Additionally, natural chimeras very rarely have a single part affected; it is usual to have almost all organs and systems affected. this is commonly found in trisomy 21 or Down's syndrome, although the difference in genetic makeup is caused by a mitotic defect rather than fusion of two seperate embryos.
That said, my mother thinks I "ate" my twin, which is why I have GID. (Had a second gestational sac, no second twin inside). Thus she believes I developed a female brain and (*ahem*) male body. To date there is no proof of this :)
People who had mismatched internal and external genitalia will often present differently; in female external genitalia, primary amenorrhoea, and in male external genitalia, delayed puberty or feminisation, and sometimes "repeated stomach cramps of a severe nature every month".
At the moment, the trend is towards looking at disorders of sexual differentiation in the brain; single-point de novo mutations are common enough to describe the epidemiology of GID.
I suggest you read the following articles which may be of interest;
P.S. as someone is about to point out, this is a page for discussion of improving the article, not about the article itself. After one week, I'll move this to my talk page.
Cheers! Lauren/ 08:45, 29 April 2007 (UTC)
Hi. I find this a very interesting debate; chimerism/mosaicism vs gender identity. I (sadly) don't think it has the potential of scientific investigation, but very interesting nonetheless. Chimerism itself (very rare in humans) is a feature of cells that you only find when you specifically look for it (even karyotyping can sometimes miss chimerism). It seems hardly possible for chimerism to exist only between the brain and the rest of us, but a higher grade of chimerism could well mean that some important areas of the brain (SDN-POA etc) 'end up with' female genetic material. Which brings me to another interesting topic: genetic material in humans. One of my personal questions: what is the difference between mosaicism and chimerism? I have worked with patient material that we call mosaicism (45X0/46XY; turner mosaicism), what in fact could be a chimere as well (female turner vs normal male). A more interesting question for me has always been: how does the immune system react to chimerism or mosaicism? Especially in low grade mosaicism. Well, to sum up: you've provided me with enough to put my thinking cap on again. Greetz Chbse 07:26, 26 September 2008 (UTC) —Preceding unsigned comment added by Chbse (talkcontribs)

Regarding SRS video[edit]

Thank you for giving me the link to the video of SRS, but today when I tried to watch, I couldn't watch! I clicked the "play" and it didn't show anything. --Edmundkh 11:15, 25 May 2007 (UTC)

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Feminism Task Force[edit]

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