Racecadotril: Difference between revisions
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'''Racecadotril''', also known as '''acetorphan''', is an [[antidiarrheal]] drug which acts as a peripherally acting [[enkephalinase inhibitor]].<ref> |
'''Racecadotril''', also known as '''acetorphan''', is an [[antidiarrheal]] drug which acts as a peripherally acting [[enkephalinase inhibitor]].<ref>{{cite journal | url = http://www.ncbi.nlm.nih.gov/pubmed/10804038 | pmid = 10804038 | volume=59 | issue=4 | year=2000 | month=April | pages=829–35; discussion 836–7 | author=Matheson AJ, Noble S}}</ref> Unlike other medications used to treat diarrhea, which [[Antipropulsive|reduce intestinal motility]], racecadotril has an [[wikt:antisecretory|antisecretory]] effect—it reduces the secretion of water and [[electrolytes]] into the intestine.<ref>(2001) "Racecadotril: an Antidiarrhoeal Suitable for Use in Infants and Young Children". ''Drug Ther Perspect'' '''17''' (8): 1–5. [http://www.medscape.com/viewarticle/406488 Free full text with registration] at [[Medscape]]</ref> It is available in France (where it was first introduced in 1993 and is widely used) and other European countries, as well as most of South America and some [[South East Asia]]n countries, but not in the United States. It is sold under the tradenames Hidrasec or, in France, Tiorfan. In Italy it is sold under the tradename Tiorfix. |
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A small [[randomized controlled trial]] found racecadotril to [[statistical significance|significantly]] reduce the duration and volume of watery diarrhea in children when given as an adjunct to [[oral rehydration therapy]].<ref>{{cite journal |author=Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M |title=Racecadotril in the treatment of acute watery diarrhea in children |journal=[[N. Engl. J. Med.]] |volume=343 |issue=7 |pages=463–7 |year=2000 |pmid=10944563 |doi= 10.1056/NEJM200008173430703|url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=10944563&promo=ONFLNS19}}</ref> |
A small [[randomized controlled trial]] found racecadotril to [[statistical significance|significantly]] reduce the duration and volume of watery diarrhea in children when given as an adjunct to [[oral rehydration therapy]].<ref>{{cite journal |author=Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M |title=Racecadotril in the treatment of acute watery diarrhea in children |journal=[[N. Engl. J. Med.]] |volume=343 |issue=7 |pages=463–7 |year=2000 |pmid=10944563 |doi= 10.1056/NEJM200008173430703|url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=10944563&promo=ONFLNS19}}</ref> |
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== References == |
== References == |
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{{Reflist|2}} |
{{Reflist|2}} |
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{{Antidiarrheals}} |
{{Antidiarrheals}} |
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{{Opioids}} |
{{Opioids}} |
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[[Category:Enkephalinase inhibitors]] |
[[Category:Enkephalinase inhibitors]] |
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Revision as of 22:17, 11 February 2011
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| Clinical data | |
|---|---|
| Other names | benzyl 2-[3-(acetylthio)-2-benzylpropanamido]acetate |
| Routes of administration | Oral |
| ATC code | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.214.352 |
| Chemical and physical data | |
| Formula | C21H23NO4S |
| Molar mass | 385.47662 g/mol g·mol−1 |
Racecadotril, also known as acetorphan, is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor.[1] Unlike other medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine.[2] It is available in France (where it was first introduced in 1993 and is widely used) and other European countries, as well as most of South America and some South East Asian countries, but not in the United States. It is sold under the tradenames Hidrasec or, in France, Tiorfan. In Italy it is sold under the tradename Tiorfix.
A small randomized controlled trial found racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.[3]
Thiorphan is the active metabolite of racecadotril.[4]
See also
- Ecadotril, the (S)-enantiomer of racecadotril
- D/DL-Phenylalanine
- RB-101
References
- ^ Matheson AJ, Noble S (2000). 59 (4): 829–35, discussion 836–7. PMID 10804038 http://www.ncbi.nlm.nih.gov/pubmed/10804038.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help); Unknown parameter|month=ignored (help) - ^ (2001) "Racecadotril: an Antidiarrhoeal Suitable for Use in Infants and Young Children". Drug Ther Perspect 17 (8): 1–5. Free full text with registration at Medscape
- ^ Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M (2000). "Racecadotril in the treatment of acute watery diarrhea in children". N. Engl. J. Med. 343 (7): 463–7. doi:10.1056/NEJM200008173430703. PMID 10944563.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F (1986). "In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF". European Journal of Pharmacology. 125 (1): 147–50. doi:10.1016/0014-2999(86)90094-4. PMID 3015640.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
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