FER (gene)

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Fer (fps/fes related) tyrosine kinase
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FER ; FerT; PPP1R74; Pe1Fe10; Pe1Fe13; Pe1Fe3; Pe1Fe6; TYK3
External IDs OMIM176942 MGI105917 HomoloGene74300 ChEMBL: 3982 GeneCards: FER Gene
EC number
Species Human Mouse
Entrez 2241 14158
Ensembl ENSG00000151422 ENSMUSG00000000127
UniProt P16591 P70451
RefSeq (mRNA) NM_005246 NM_001037997
RefSeq (protein) NP_005237 NP_001033086
Location (UCSC) Chr 5:
108.08 – 108.53 Mb
Chr 17:
63.9 – 64.14 Mb
PubMed search [1] [2]

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.[1]

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.[1]


FER (gene) has been shown to interact with TMF1[2] and Cortactin.[3]


  1. ^ a b "Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)". 
  2. ^ Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. (NETHERLANDS) 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951. 
  3. ^ Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER". J. Biol. Chem. (UNITED STATES) 273 (36): 23542–8. doi:10.1074/jbc.273.36.23542. ISSN 0021-9258. PMID 9722593. 

Further reading[edit]