HCK

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HCK proto-oncogene, Src family tyrosine kinase
Protein HCK PDB 1ad5.png
PDB rendering based on 1ad5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HCK ; JTK9; p59Hck; p61Hck
External IDs OMIM142370 MGI96052 HomoloGene20489 ChEMBL: 3234 GeneCards: HCK Gene
EC number 2.7.10.2
RNA expression pattern
PBB GE HCK 208018 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3055 15162
Ensembl ENSG00000101336 ENSMUSG00000003283
UniProt P08631 P08103
RefSeq (mRNA) NM_001172129 NM_001172117
RefSeq (protein) NP_001165600 NP_001165588
Location (UCSC) Chr 20:
30.64 – 30.69 Mb
Chr 2:
153.11 – 153.15 Mb
PubMed search [1] [2]

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.[1]

The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types, and belongs to the Src family of tyrosine kinases. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.[2]

Interactions[edit]

HCK has been shown to interact with BCR gene,[3][4] ELMO1,[5] Cbl gene,[6][7] RAS p21 protein activator 1,[8] RASA3,[8] Granulocyte colony-stimulating factor receptor,[9] ADAM15[10] and RAPGEF1.[11]

References[edit]

  1. ^ Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD (August 1987). "Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells". Mol Cell Biol 7 (6): 2267–75. PMC 365351. PMID 3496523. 
  2. ^ "Entrez Gene: HCK hemopoietic cell kinase". 
  3. ^ Stanglmaier, M; Warmuth M; Kleinlein I; Reis S; Hallek M (February 2003). "The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains". Leukemia (England) 17 (2): 283–9. doi:10.1038/sj.leu.2402778. ISSN 0887-6924. PMID 12592324. 
  4. ^ Lionberger, J M; Wilson M B; Smithgall T E (June 2000). "Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck". J. Biol. Chem. (UNITED STATES) 275 (24): 18581–5. doi:10.1074/jbc.C000126200. ISSN 0021-9258. PMID 10849448. 
  5. ^ Scott, Margaret Porter; Zappacosta Francesca; Kim Eun Young; Annan Roland S; Miller W Todd (August 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. (United States) 277 (31): 28238–46. doi:10.1074/jbc.M202783200. ISSN 0021-9258. PMID 12029088. 
  6. ^ Howlett, Christopher J; Robbins Stephen M (March 2002). "Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation". Oncogene (England) 21 (11): 1707–16. doi:10.1038/sj.onc.1205228. ISSN 0950-9232. PMID 11896602. 
  7. ^ Howlett, C J; Bisson S A; Resek M E; Tigley A W; Robbins S M (April 1999). "The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. (UNITED STATES) 257 (1): 129–38. doi:10.1006/bbrc.1999.0427. ISSN 0006-291X. PMID 10092522. 
  8. ^ a b Briggs, S D; Bryant S S; Jove R; Sanderson S D; Smithgall T E (June 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". J. Biol. Chem. (UNITED STATES) 270 (24): 14718–24. doi:10.1074/jbc.270.24.14718. ISSN 0021-9258. PMID 7782336. 
  9. ^ Ward, A C; Monkhouse J L; Csar X F; Touw I P; Bello P A (October 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochem. Biophys. Res. Commun. (UNITED STATES) 251 (1): 117–23. doi:10.1006/bbrc.1998.9441. ISSN 0006-291X. PMID 9790917. 
  10. ^ Poghosyan, Zaruhi; Robbins Stephen M; Houslay Miles D; Webster Ailsa; Murphy Gillian; Edwards Dylan R (February 2002). "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". J. Biol. Chem. (United States) 277 (7): 4999–5007. doi:10.1074/jbc.M107430200. ISSN 0021-9258. PMID 11741929. 
  11. ^ Shivakrupa, R; Radha Vegesna; Sudhakar Ch; Swarup Ghanshyam (December 2003). "Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain". J. Biol. Chem. (United States) 278 (52): 52188–94. doi:10.1074/jbc.M310656200. ISSN 0021-9258. PMID 14551197. 

Further reading[edit]