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Protein tyrosine kinase 6
Protein PTK6 PDB 1rja.png
NMR structure of the SH2 domain of PTK6.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTK6 ; BRK
External IDs OMIM602004 MGI99683 HomoloGene68494 IUPHAR: 2182 ChEMBL: 4601 GeneCards: PTK6 Gene
EC number
RNA expression pattern
PBB GE PTK6 206482 at tn.png
More reference expression data
Species Human Mouse
Entrez 5753 20459
Ensembl ENSG00000101213 ENSMUSG00000038751
UniProt Q13882 Q64434
RefSeq (mRNA) NM_001256358 NM_009184
RefSeq (protein) NP_001243287 NP_033210
Location (UCSC) Chr 20:
62.16 – 62.17 Mb
Chr 2:
181.19 – 181.2 Mb
PubMed search [1] [2]

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[2][3][4]


Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[4]

Clinical significance[edit]

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[4]


PTK6 has been shown to interact with STAP2[5] and KHDRBS1.[6]


  1. ^ PDB 1rja; Hong E, Shin J, Kim HI, Lee ST, Lee W (July 2004). "Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain". J. Biol. Chem. 279 (28): 29700–8. doi:10.1074/jbc.M313185200. PMID 15056653. 
  2. ^ Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene 8 (12): 3403–10. PMID 8247543. 
  3. ^ Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 77 (3–4): 271–2. doi:10.1159/000134595. PMID 9284935. 
  4. ^ a b c "Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6". 
  5. ^ Mitchell, P J; Sara E A; Crompton M R (August 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene (ENGLAND) 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. ISSN 0950-9232. PMID 10980601. 
  6. ^ Derry, J J; Richard S; Valderrama Carvajal H; Ye X; Vasioukhin V; Cochrane A W; Chen T; Tyner A L (August 2000). "Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability". Mol. Cell. Biol. (UNITED STATES) 20 (16): 6114–26. doi:10.1128/MCB.20.16.6114-6126.2000. ISSN 0270-7306. PMC 86087. PMID 10913193. 

Further reading[edit]