ROR1

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Receptor tyrosine kinase-like orphan receptor 1
Identifiers
Symbols ROR1 ; NTRKR1; dJ537F10.1
External IDs OMIM602336 MGI1347520 HomoloGene3675 GeneCards: ROR1 Gene
EC number 2.7.10.1
Orthologs
Species Human Mouse
Entrez 4919 26563
Ensembl ENSG00000185483 ENSMUSG00000035305
UniProt Q01973 Q9Z139
RefSeq (mRNA) NM_001083592 NM_013845
RefSeq (protein) NP_001077061 NP_038873
Location (UCSC) Chr 1:
64.24 – 64.65 Mb
Chr 4:
100.1 – 100.44 Mb
PubMed search [1] [2]

Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene.[1][2][3] ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.

Function[edit]

The protein encoded by this gene is a receptor tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors.[1] ROR1 is currently under investigation for its role in the metastasis of cancer cells. [4]

References[edit]

  1. ^ a b "Entrez Gene: receptor tyrosine kinase-like orphan receptor 1". 
  2. ^ Masiakowski P, Carroll RD (December 1992). "A novel family of cell surface receptors with tyrosine kinase-like domain". J. Biol. Chem. 267 (36): 26181–90. PMID 1334494. 
  3. ^ Reddy UR, Phatak S, Pleasure D (October 1996). "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains". Oncogene 13 (7): 1555–9. PMID 8875995. 
  4. ^ http://www.foxnews.com/health/2013/06/14/stopping-cancer-spread-researchers-identify-protein-that-regulates-cancer/?test=latestnews

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.