Tyrosine-protein kinase CSK

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This article is about the kinase CSK, for the kinase that is phosphorylated by CSK, see c-Src.
C-src tyrosine kinase
PBB Protein CSK image.jpg
PDB rendering based on 1byg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CSK ; MGC117393
External IDs OMIM124095 MGI88537 HomoloGene55818 ChEMBL: 2634 GeneCards: CSK Gene
EC number
RNA expression pattern
PBB GE CSK 202329 at tn.png
More reference expression data
Species Human Mouse
Entrez 1445 12988
Ensembl ENSG00000103653 ENSMUSG00000032312
UniProt P41240 P41241
RefSeq (mRNA) NM_001127190 NM_007783
RefSeq (protein) NP_001120662 NP_031809
Location (UCSC) Chr 15:
74.78 – 74.8 Mb
Chr 9:
57.63 – 57.65 Mb
PubMed search [1] [2]

Tyrosine-protein kinase CSK also known as C-Src kinase or C-terminal Src kinase is an enzyme that in humans is encoded by the CSK gene.[1] This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1.[2][3]


Tyrosine-protein kinase CSK suppresses activity of the Src family of protein kinases by phosphorylation of Src family members at a conserved C-terminal site in Src.[4][5][6][7] Csk's control of the Src family activity is widely thought to be central to regulation of the immune response.[8] Src also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion.[9][10]

Clinical significance[edit]

Csk's interaction with a phosphatase ("Lyp", gene product of PTPN22) is possibly associated with the increased autoimmune diseases associated with PTPN22 mutations.[11]


  1. ^ "Entrez Gene: C-src tyrosine kinase". Retrieved 2013-07-11. 
  2. ^ Bergman M, Mustelin T, Oetken C, Partanen J, Flint NA, Amrein KE, Autero M, Burn P, Alitalo K (August 1992). "The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity". EMBO J. 11 (8): 2919–24. PMC 556773. PMID 1639064. 
  3. ^ Sun G, Budde RJ (September 1997). "Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system". Arch. Biochem. Biophys. 345 (1): 135–42. doi:10.1006/abbi.1997.0236. PMID 9281320. 
  4. ^ Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H (May 1991). "Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src". Nature 351 (6321): 69–72. doi:10.1038/351069a0. PMID 1709258. 
  5. ^ Nada S, Yagi T, Takeda H, Tokunaga T, Nakagawa H, Ikawa Y, Okada M, Aizawa S (June 1993). "Constitutive activation of Src family kinases in mouse embryos that lack Csk". Cell 73 (6): 1125–35. doi:10.1016/0092-8674(93)90642-4. PMID 8513497. 
  6. ^ Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC (November 2006). "C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases". J. Biol. Chem. 281 (44): 32988–99. doi:10.1074/jbc.M602951200. PMID 16959780. 
  7. ^ Chong YP, Mulhern TD, Cheng HC (September 2005). "C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases". Growth Factors 23 (3): 233–44. doi:10.1080/08977190500178877. PMID 16243715. 
  8. ^ Latour S, Veillette A (June 2001). "Proximal protein tyrosine kinases in immunoreceptor signaling". Curr. Opin. Immunol. 13 (3): 299–306. doi:10.1016/S0952-7915(00)00219-3. PMID 11406361. 
  9. ^ Zan L, Wu H, Jiang J, Zhao S, Song Y, Teng G, Li H, Jia Y, Zhou M, Zhang X, Qi J, Wang J. (July 2011). "Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema". Neurochem Int. 58 (8): 872–9. doi:10.1016/j.neuint.2011.02.014. PMC 3100427. PMID 21334414. 
  10. ^ Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J. (March 2014). "Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion.". Neuroscience. 262 (3): 118–128. doi:10.1016/j.neuroscience.2013.12.060. PMID 24412374. 
  11. ^ Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N (August 2010). "Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue". J. Biol. Chem. 285 (34): 26506–18. doi:10.1074/jbc.M110.111104. PMC 2924087. PMID 20538612. 

External links[edit]