Leukocyte receptor tyrosine kinase

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Leukocyte receptor tyrosine kinase
Symbols LTK ; TYK1
External IDs OMIM151520 MGI96840 HomoloGene130502 ChEMBL: 5627 GeneCards: LTK Gene
EC number
RNA expression pattern
PBB GE LTK 207106 s at tn.png
PBB GE LTK 217184 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4058 17005
Ensembl ENSG00000062524 ENSMUSG00000027297
UniProt P29376 P08923
RefSeq (mRNA) NM_001135685 NM_008523
RefSeq (protein) NP_001129157 NP_032549
Location (UCSC) Chr 15:
41.8 – 41.81 Mb
Chr 2:
119.75 – 119.76 Mb
PubMed search [1] [2]

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.[1][2]

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.[3] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]


LTK has been shown to interact with IRS-1, Shc, and PIK3R1.[4][5]


  1. ^ Maru Y, Hirai H, Takaku F (May 1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res 5 (3): 199–204. PMID 2320375. 
  2. ^ a b "Entrez Gene: LTK leukocyte tyrosine kinase". 
  3. ^ Lopes, Susana (2008).  Missing or empty |title= (help)
  4. ^ Kozutsumi, H; Toyoshima H; Hagiwara K; Yazaki Y; Hirai H (October 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene (ENGLAND) 9 (10): 2991–8. ISSN 0950-9232. PMID 8084603. 
  5. ^ Ueno, H; Honda H; Nakamoto T; Yamagata T; Sasaki K; Miyagawa K; Mitani K; Yazaki Y; Hirai H (June 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene (ENGLAND) 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. ISSN 0950-9232. PMID 9223670. 

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