Leukocyte receptor tyrosine kinase

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Leukocyte receptor tyrosine kinase
Symbols LTK ; TYK1
External IDs OMIM151520 MGI96840 HomoloGene130502 ChEMBL: 5627 GeneCards: LTK Gene
EC number
RNA expression pattern
PBB GE LTK 207106 s at tn.png
PBB GE LTK 217184 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4058 17005
Ensembl ENSG00000062524 ENSMUSG00000027297
UniProt P29376 P08923
RefSeq (mRNA) NM_001135685 NM_008523
RefSeq (protein) NP_001129157 NP_032549
Location (UCSC) Chr 15:
41.8 – 41.81 Mb
Chr 2:
119.75 – 119.76 Mb
PubMed search [1] [2]

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.[1][2]

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.[3] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]


LTK has been shown to interact with IRS-1, Shc, and PIK3R1.[4][5]


  1. ^ Maru Y, Hirai H, Takaku F (May 1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res 5 (3): 199–204. PMID 2320375. 
  2. ^ a b "Entrez Gene: LTK leukocyte tyrosine kinase". 
  3. ^ Lopes, Susana (2008).  Missing or empty |title= (help)
  4. ^ Kozutsumi, H; Toyoshima H; Hagiwara K; Yazaki Y; Hirai H (October 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene (ENGLAND) 9 (10): 2991–8. ISSN 0950-9232. PMID 8084603. 
  5. ^ Ueno, H; Honda H; Nakamoto T; Yamagata T; Sasaki K; Miyagawa K; Mitani K; Yazaki Y; Hirai H (June 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene (ENGLAND) 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. ISSN 0950-9232. PMID 9223670. 

Further reading[edit]

  • Krolewski JJ, Dalla-Favera R (1991). "The ltk gene encodes a novel receptor-type protein tyrosine kinase.". Embo J. 10 (10): 2911–9. PMC 453005. PMID 1655406. 
  • Krolewski JJ, Lee R, Eddy R, et al. (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes.". Oncogene 5 (3): 277–82. PMID 2156206. 
  • Ben-Neriah Y, Bauskin AR (1988). "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.". Nature 333 (6174): 672–6. doi:10.1038/333672a0. PMID 2836739. 
  • Toyoshima H, Kozutsumi H, Maru Y, et al. (1993). "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. doi:10.1073/pnas.90.12.5404. PMID 7685902. 
  • Richard I, Broux O, Chiannilkulchai N, et al. (1995). "Regional localization of human chromosome 15 loci.". Genomics 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID 7851890. 
  • Kozutsumi H, Toyoshima H, Hagiwara K, et al. (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.". Oncogene 9 (10): 2991–8. PMID 8084603. 
  • Kozutsumi H, Toyoshima H, Hagiwara K, et al. (1993). "Identification of the human ltk gene product in placenta and hematopoietic cell lines.". Biochem. Biophys. Res. Commun. 190 (2): 674–9. doi:10.1006/bbrc.1993.1101. PMID 8427607. 
  • Ueno H, Sasaki K, Kozutsumi H, et al. (1996). "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.". J. Biol. Chem. 271 (44): 27707–14. doi:10.1074/jbc.271.44.27707. PMID 8910363. 
  • Snijders AJ, Ho SC, Haase VH, et al. (1997). "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin.". J. Biol. Chem. 272 (2): 1297–301. doi:10.1074/jbc.272.2.1297. PMID 8995435. 
  • Ueno H, Honda H, Nakamoto T, et al. (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.". Oncogene 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670. 
  • Espanel X, Huguenin-Reggiani M, Van Huijsduijnen RH (2003). "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.". Protein Sci. 11 (10): 2326–34. doi:10.1110/ps.0213402. PMID 12237455. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Li N, Nakamura K, Jiang Y, et al. (2004). "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.". Hum. Mol. Genet. 13 (2): 171–9. doi:10.1093/hmg/ddh020. PMID 14695357.