Tyrosine-protein kinase-like 7 is an enzyme that in humans is encoded by the PTK7gene.
Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.". Oncogene8 (12): 3403–10. PMID8247543.
Park SK, Lee HS, Lee ST (1997). "Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.". J. Biochem.119 (2): 235–9. PMID8882711.
Banga SS, Ozer HL, Park SK, Lee ST (1997). "Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1→p12.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet.76 (1–2): 43–4. doi:10.1159/000134511. PMID9154124.
Jung JW, Ji AR, Lee J et al. (2003). "Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA". Biochim. Biophys. Acta1579 (2–3): 153–63. PMID12427550.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol.21 (6): 660–6. doi:10.1038/nbt827. PMID12754519.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Kobus FJ, Fleming KG (2005). "The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions". Biochemistry44 (5): 1464–70. doi:10.1021/bi048076l. PMID15683231.
Katoh M, Katoh M (2007). "Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells". Int. J. Mol. Med.20 (3): 405–9. PMID17671748.