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Protein tyrosine kinase 7
Symbols PTK7 ; CCK-4; CCK4
External IDs OMIM601890 MGI1918711 HomoloGene43672 GeneCards: PTK7 Gene
EC number
RNA expression pattern
PBB GE PTK7 207011 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5754 71461
Ensembl ENSG00000112655 ENSMUSG00000023972
UniProt Q13308 Q8BKG3
RefSeq (mRNA) NM_001270398 NM_175168
RefSeq (protein) NP_001257327 NP_780377
Location (UCSC) Chr 6:
43.04 – 43.13 Mb
Chr 17:
46.56 – 46.63 Mb
PubMed search [1] [2]

Tyrosine-protein kinase-like 7 is an enzyme that in humans is encoded by the PTK7 gene.[1][2]

Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.[2]


  1. ^ Mossie K, Jallal B, Alves F, Sures I, Plowman GD, Ullrich A (Dec 1995). "Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family". Oncogene 11 (10): 2179–84. PMID 7478540. 
  2. ^ a b "Entrez Gene: PTK7 PTK7 protein tyrosine kinase 7". 

Further reading[edit]

  • Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.". Oncogene 8 (12): 3403–10. PMID 8247543. 
  • Park SK, Lee HS, Lee ST (1997). "Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.". J. Biochem. 119 (2): 235–9. PMID 8882711. 
  • Banga SS, Ozer HL, Park SK, Lee ST (1997). "Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1→p12.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 76 (1–2): 43–4. doi:10.1159/000134511. PMID 9154124. 
  • Jung JW, Ji AR, Lee J et al. (2003). "Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA". Biochim. Biophys. Acta 1579 (2–3): 153–63. PMID 12427550. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Kobus FJ, Fleming KG (2005). "The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions". Biochemistry 44 (5): 1464–70. doi:10.1021/bi048076l. PMID 15683231. 
  • Katoh M, Katoh M (2007). "Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells". Int. J. Mol. Med. 20 (3): 405–9. PMID 17671748.