PTK7

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Protein tyrosine kinase 7
Identifiers
Symbols PTK7 ; CCK-4; CCK4
External IDs OMIM601890 MGI1918711 HomoloGene43672 GeneCards: PTK7 Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE PTK7 207011 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5754 71461
Ensembl ENSG00000112655 ENSMUSG00000023972
UniProt Q13308 Q8BKG3
RefSeq (mRNA) NM_001270398 NM_175168
RefSeq (protein) NP_001257327 NP_780377
Location (UCSC) Chr 6:
43.04 – 43.13 Mb
Chr 17:
46.56 – 46.63 Mb
PubMed search [1] [2]

Tyrosine-protein kinase-like 7 is an enzyme that in humans is encoded by the PTK7 gene.[1][2]

Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene an intracellular domain with tyrosine kinase homology and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.[2]

PTK7 serves as a context-dependent signalling switch for the Wnt pathways (particularly in planar cell polarity related functions such as convergent extension and neural crest cell migration) and appears to have similar functions for Plexin and Flt-1 pathways.Peradziryi H, Tolwinski NS, Borchers A (2012). "The many roles of PTK7: A versatile regulator of cell-cell communication.". Archives of Biochemistry and Biophysics 524 (1): 1–6. doi:10.1016/j.abb.2011.12.019. PMID 22230326. 

References[edit]

  1. ^ Mossie K, Jallal B, Alves F, Sures I, Plowman GD, Ullrich A (Dec 1995). "Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family". Oncogene 11 (10): 2179–84. PMID 7478540. 
  2. ^ a b "Entrez Gene: PTK7 PTK7 protein tyrosine kinase 7". 

Further reading[edit]

  • Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.". Oncogene 8 (12): 3403–10. PMID 8247543. 
  • Park SK, Lee HS, Lee ST (1997). "Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.". J. Biochem. 119 (2): 235–9. doi:10.1093/oxfordjournals.jbchem.a021228. PMID 8882711. 
  • Banga SS, Ozer HL, Park SK, Lee ST (1997). "Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1→p12.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 76 (1–2): 43–4. doi:10.1159/000134511. PMID 9154124. 
  • Jung JW, Ji AR, Lee J et al. (2003). "Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA". Biochim. Biophys. Acta 1579 (2–3): 153–63. doi:10.1016/s0167-4781(02)00536-5. PMID 12427550. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Kobus FJ, Fleming KG (2005). "The GxxxG-containing transmembrane domain of the CCK4 oncogene does not encode preferential self-interactions". Biochemistry 44 (5): 1464–70. doi:10.1021/bi048076l. PMID 15683231. 
  • Katoh M, Katoh M (2007). "Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells". Int. J. Mol. Med. 20 (3): 405–9. doi:10.3892/ijmm.20.3.405. PMID 17671748.