DDR1

For the older type of computer memory, see DDR SDRAM.

Discoidin domain receptor tyrosine kinase 1
Identifiers
Symbols	DDR1; CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
External IDs	OMIM: 600408 MGI: 99216 HomoloGene: 68212 GeneCards: DDR1 Gene
EC number	2.7.10.1
Gene Ontology Molecular function • nucleotide binding • protein kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor activity • protein binding • collagen binding • ATP binding • transferase activity, transferring phosphorus-containing groups • protein tyrosine kinase collagen receptor activity Cellular component • extracellular region • plasma membrane • integral to plasma membrane • basolateral plasma membrane Biological process • regulation of cell growth • regulation of cell-matrix adhesion • cell adhesion • embryo implantation • negative regulation of cell proliferation • peptidyl-tyrosine phosphorylation • organ regeneration • collagen-activated tyrosine kinase receptor signaling pathway • ear development • skin development • protein autophosphorylation • branching involved in mammary gland duct morphogenesis • mammary gland alveolus development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	780	12305
Ensembl	ENSG00000137332	ENSMUSG00000003534
UniProt	Q08345	Q03146
RefSeq (mRNA)	NM_001202521.1	NM_001198831.1
RefSeq (protein)	NP_001189450.1	NP_001185760.1
Location (UCSC)	Chr 6: 30.84 – 30.87 Mb	Chr 17: 35.82 – 35.84 Mb
PubMed search	[1]	[2]

Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

References

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Further reading

• Edelhoff S, Sweetser DA, Disteche CM (1995). "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C". Genomics 25 (1): 309–11. doi:10.1016/0888-7543(95)80144-B. PMID 7774938. 
• Shelling AN, Butler R, Jones T et al (1995). "Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16". Genomics 25 (2): 584–7. doi:10.1016/0888-7543(95)80065-T. PMID 7789998. 
• Weiner TM, Liu ET, Craven RJ, Cance WG (1995). "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors". Ann. Surg. Oncol. 1 (1): 18–27. doi:10.1007/BF02303537. PMID 7834423. 
• Laval S, Butler R, Shelling AN et al (1995). "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line". Cell Growth Differ. 5 (11): 1173–83. PMID 7848919. 
• Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". Mol. Cell. Biol. 14 (4): 2713–21. PMC 358637. PMID 8139570. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=358637. 
• Di Marco E, Cutuli N, Guerra L et al (1993). "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues". J. Biol. Chem. 268 (32): 24290–5. PMID 8226977. 
• Perez JL, Shen X, Finkernagel S et al (1994). "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene 9 (1): 211–9. PMID 8302582. 
• Johnson JD, Edman JC, Rutter WJ (1993). "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5677–81. doi:10.1073/pnas.90.12.5677. PMC 46784. PMID 8390675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=46784. 
• Perez JL, Jing SQ, Wong TW (1996). "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines". Oncogene 12 (7): 1469–77. PMID 8622863. 
• Valent A, Meddeb M, Danglot G et al (1996). "Assignment of the NTRK4 (trkE) gene to chromosome 6p21". Hum. Genet. 98 (1): 12–5. doi:10.1007/s004390050152. PMID 8682498. 
• Playford MP, Butler RJ, Wang XC et al (1996). "The genomic structure of discoidin receptor tyrosine kinase". Genome Res. 6 (7): 620–7. doi:10.1101/gr.6.7.620. PMID 8796349. 
• Sakuma S, Saya H, Tada M et al (1997). "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein". FEBS Lett. 398 (2–3): 165–9. doi:10.1016/S0014-5793(96)01234-3. PMID 8977099. 
• Nemoto T, Ohashi K, Akashi T et al (1998). "Overexpression of protein tyrosine kinases in human esophageal cancer". Pathobiology 65 (4): 195–203. doi:10.1159/000164123. PMID 9396043. 
• Tanaka K, Nagayama Y, Nakano T et al (1998). "Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid". Endocrinology 139 (3): 852–8. doi:10.1210/en.139.3.852. PMID 9492013. 
• Vogel W, Gish GD, Alves F, Pawson T (1998). "The discoidin domain receptor tyrosine kinases are activated by collagen". Mol. Cell 1 (1): 13–23. doi:10.1016/S1097-2765(00)80003-9. PMID 9659899. 
• Shrivastava A, Radziejewski C, Campbell E et al (1998). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Mol. Cell 1 (1): 25–34. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900. 
• Vogel W, Brakebusch C, Fässler R et al (2000). "Discoidin domain receptor 1 is activated independently of beta(1) integrin". J. Biol. Chem. 275 (8): 5779–84. doi:10.1074/jbc.275.8.5779. PMID 10681566. 
• Foehr ED, Tatavos A, Tanabe E et al (2000). "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors". FASEB J. 14 (7): 973–81. PMID 10783152. 
• Weiner HL, Huang H, Zagzag D et al (2001). "Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors". Neurosurgery 47 (6): 1400–9. doi:10.1097/00006123-200012000-00028. PMID 11126911. 
• Mohan RR, Mohan RR, Wilson SE (2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea". Exp. Eye Res. 72 (1): 87–92. doi:10.1006/exer.2000.0932. PMID 11133186. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.