UBE2D3

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Ubiquitin-conjugating enzyme E2D 3
Protein UBE2D3 PDB 1ur6.png
PDB rendering based on 1ur6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBE2D3 ; E2(17)KB3; UBC4/5; UBCH5C
External IDs OMIM602963 MGI1913355 HomoloGene123914 GeneCards: UBE2D3 Gene
EC number 6.3.2.19
Orthologs
Species Human Mouse
Entrez 7323 66105
Ensembl ENSG00000109332 ENSMUSG00000078578
UniProt P61077 P61079
RefSeq (mRNA) NM_003340 NM_025356
RefSeq (protein) NP_003331 NP_079632
Location (UCSC) Chr 4:
103.72 – 103.79 Mb
Chr 3:
135.44 – 135.47 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.[2]

Interactions[edit]

UBE2D3 has been shown to interact with NEDD4.[3][4]

References[edit]

  1. ^ Jensen JP, Bates PW, Yang M, Vierstra RD, Weissman AM (Jan 1996). "Identification of a family of closely related human ubiquitin conjugating enzymes". J Biol Chem 270 (51): 30408–14. doi:10.1074/jbc.270.51.30408. PMID 8530467. 
  2. ^ a b "Entrez Gene: UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)". 
  3. ^ Anan, T; Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells (ENGLAND) 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. ISSN 1356-9597. PMID 9990509. 
  4. ^ Wang, Xinjiang; Shi Yuji, Wang Junru, Huang Guochang, Jiang Xuejun (Sep 2008). "Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation". Biochem. J. (England) 414 (2): 221–9. doi:10.1042/BJ20080674. PMID 18498243. 

Further reading[edit]