UBE2N

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Ubiquitin-conjugating enzyme E2N
Protein UBE2N PDB 1j7d.png
PDB rendering based on 1j7d.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBE2N ; UBC13; UbcH-ben; UbcH13
External IDs OMIM603679 MGI1934835 HomoloGene100734 ChEMBL: 6089 GeneCards: UBE2N Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE UBE2N 212751 at tn.png
PBB GE UBE2N 201523 x at tn.png
PBB GE UBE2N 201524 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7334 93765
Ensembl ENSG00000177889 ENSMUSG00000074781
UniProt P61088 P61089
RefSeq (mRNA) NM_003348 NM_080560.3
RefSeq (protein) NP_003339 NP_542127.1
Location (UCSC) Chr 12:
93.8 – 93.84 Mb
Chr 10:
94.98 – 95.01 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.[2]

Interactions[edit]

UBE2N has been shown to interact with Aurora A kinase,[3] TRAF2,[4] TRAF6,[4] HLTF[5] and UBE2V1.[4]

References[edit]

  1. ^ Yamaguchi T, Kim NS, Sekine S, Seino H, Osaka F, Yamao F, Kato S (February 1997). "Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product". J Biochem 120 (3): 494–97. doi:10.1093/oxfordjournals.jbchem.a021440. PMID 8902611. 
  2. ^ a b "Entrez Gene: UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)". 
  3. ^ Ewart-Toland, Amanda; Briassouli Paraskevi, de Koning John P, Mao Jian-Hua, Yuan Jinwei, Chan Florence, MacCarthy-Morrogh Lucy, Ponder Bruce A J, Nagase Hiroki, Burn John, Ball Sarah, Almeida Maria, Linardopoulos Spiros, Balmain Allan (August 2003). "Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human". Nat. Genet. (United States) 34 (4): 403–12. doi:10.1038/ng1220. ISSN 1061-4036. PMID 12881723. 
  4. ^ a b c Deng, L; Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen Z J (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell (UNITED STATES) 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. ISSN 0092-8674. PMID 11057907. 
  5. ^ Unk, Ildiko; Hajdú Ildikó, Fátyol Károly, Hurwitz Jerard, Yoon Jung-Hoon, Prakash Louise, Prakash Satya, Haracska Lajos (March 2008). "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (10): 3768–73. doi:10.1073/pnas.0800563105. PMC 2268824. PMID 18316726. 

Further reading[edit]