NPR2

NPR2
Identifiers
Aliases	NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2, GCB, AMD1, GC-B
External IDs	OMIM: 108961; MGI: 97372; HomoloGene: 2970; GeneCards: NPR2; OMA:NPR2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 35,791,003 bp End 35,809,732 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 A5|4 23.05 cM Start 43,631,935 bp End 43,651,244 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary canal of the cervix ascending aorta stromal cell of endometrium left uterine tube tibial nerve left coronary artery right coronary artery gastric mucosa Top expressed in soleus muscle ankle extraocular muscle median eminence cumulus cell spinal ganglia cerebellar cortex superior frontal gyrus digastric muscle calvaria More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase activity nucleotide binding hormone binding GTP binding lyase activity identical protein binding phosphorus-oxygen lyase activity ATP binding guanylate cyclase activity natriuretic peptide receptor activity peptide hormone binding protein binding adenylate cyclase activity peptide receptor activity Cellular component integral component of membrane membrane plasma membrane guanylate cyclase complex, soluble integral component of plasma membrane intracellular anatomical structure Biological process negative regulation of meiotic cell cycle regulation of cardiac conduction intracellular signal transduction ossification negative regulation of oocyte maturation cyclic nucleotide biosynthetic process regulation of blood pressure cGMP biosynthetic process protein phosphorylation cellular response to granulocyte macrophage colony-stimulating factor stimulus bone development receptor guanylyl cyclase signaling pathway reproductive process positive regulation of cGMP-mediated signaling cGMP-mediated signaling signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4882 230103 Ensembl ENSG00000159899 ENSMUSG00000028469 UniProt P20594 Q6VVW5 RefSeq (mRNA) NM_000907 NM_003995 NM_001378923 NM_173788 NM_001355466 RefSeq (protein) NP_003986 NP_001365852 NP_776149 NP_001342395 Location (UCSC) Chr 9: 35.79 – 35.81 Mb Chr 4: 43.63 – 43.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), also known as NPR2, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR2 gene.

See also

• Atrial natriuretic peptide receptor

Further reading

• Fox AA, Collard CD, Shernan SK, et al. (2009). "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting". Anesthesiology. 110 (4): 738–47. doi:10.1097/ALN.0b013e31819c7496. PMC 2735337. PMID 19326473.
• Potthast R, Abbey-Hosch SE, Antos LK, et al. (2004). "Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B". J. Biol. Chem. 279 (47): 48513–9. doi:10.1074/jbc.M408247200. PMID 15371450.
• Liew D, Schneider H, D'Agostino J, et al. (2004). "Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al". Diabetes Care. 27 (3): 848, author reply 848–9. doi:10.2337/diacare.27.3.848. PMID 14988324.
• Antos LK, Abbey-Hosch SE, Flora DR, Potter LR (2005). "ATP-independent activation of natriuretic peptide receptors". J. Biol. Chem. 280 (29): 26928–32. doi:10.1074/jbc.M505648200. PMID 15911610.
• Poreba R; Poczatek K; Gać P; et al. (2009). "SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension". Pol. Arch. Med. Wewn. 119 (4): 219–24. PMID 19413180.
• Koller KJ, Goeddel DV (1992). "Molecular biology of the natriuretic peptides and their receptors". Circulation. 86 (4): 1081–8. doi:10.1161/01.cir.86.4.1081. PMID 1327579.
• Fan D, Bryan PM, Antos LK, et al. (2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize". Mol. Pharmacol. 67 (1): 174–83. doi:10.1124/mol.104.002436. PMID 15459247. S2CID 53520.
• Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel TH (2007). "Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy". J. Mol. Med. 85 (8): 797–810. doi:10.1007/s00109-007-0183-4. PMID 17429599. S2CID 42834676.
• Rahmutula D, Cui J, Chen S, Gardner DG (2004). "Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1". Hypertension. 44 (3): 283–8. doi:10.1161/01.HYP.0000136908.60317.92. PMID 15262909.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Hume AN, Buttgereit J, Al-Awadhi AM, et al. (2009). "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux". Hum. Mol. Genet. 18 (2): 267–77. doi:10.1093/hmg/ddn354. PMC 2638773. PMID 18945719.
• Schulz S (2005). "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides. 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070. S2CID 24299700.
• Tsuji T, Kunieda T (2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse". J. Biol. Chem. 280 (14): 14288–92. doi:10.1074/jbc.C500024200. PMID 15722353.
• Dickey DM, Yoder AR, Potter LR (2009). "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation". J. Biol. Chem. 284 (29): 19196–202. doi:10.1074/jbc.M109.010777. PMC 2740543. PMID 19458086.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Nozohoor S, Nilsson J, Lührs C, et al. (2009). "B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement". J. Cardiothorac. Vasc. Anesth. 23 (2): 161–5. doi:10.1053/j.jvca.2008.11.006. PMID 19167912.
• Hachiya R, Ohashi Y, Kamei Y, et al. (2007). "Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development". J. Clin. Endocrinol. Metab. 92 (10): 4009–14. doi:10.1210/jc.2007-1101. PMID 17652215.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bartels CF, Bükülmez H, Padayatti P, et al. (2004). "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux". Am. J. Hum. Genet. 75 (1): 27–34. doi:10.1086/422013. PMC 1182004. PMID 15146390.
• van den Akker F (2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors". J. Mol. Biol. 311 (5): 923–37. doi:10.1006/jmbi.2001.4922. PMID 11556325.

External links

• NPR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.