PTPRN

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PTPRN
Protein PTPRN PDB 2i1y.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTPRN, IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, protein tyrosine phosphatase, receptor type N
External IDs MGI: 102765 HomoloGene: 48142 GeneCards: PTPRN
RNA expression pattern
PBB GE PTPRN 204945 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199763
NM_001199764
NM_002846

NM_008985

RefSeq (protein)

NP_001186692
NP_001186693
NP_002837

n/a

Location (UCSC) Chr 2: 219.29 – 219.31 Mb Chr 1: 75.25 – 75.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Receptor-type tyrosine-protein phosphatase-like N is an enzyme that in humans is encoded by the PTPRN gene.[3][4]

Function[edit]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family and PTPRN subfamily. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.[4]

Interactions[edit]

PTPRN has been shown to interact with SPTBN4.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lan MS, Lu J, Goto Y, Notkins AL (August 1994). "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma". DNA Cell Biol. 13 (5): 505–14. doi:10.1089/dna.1994.13.505. PMID 8024693. 
  4. ^ a b "Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N". 
  5. ^ Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M (November 2000). "βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349Freely accessible. PMID 11086001. 

Further reading[edit]