PTPRH

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PTPRH
Identifiers
Aliases PTPRH, R-PTP-H, SAP1, protein tyrosine phosphatase, receptor type H
External IDs MGI: 3026877 HomoloGene: 37693 GeneCards: PTPRH
RNA expression pattern
PBB GE PTPRH 208300 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161440
NM_002842

NM_207270

RefSeq (protein)

n/a

NP_997153

Location (UCSC) Chr 19: 55.18 – 55.21 Mb Chr 7: 4.55 – 4.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.[3][4]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C, et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem. 269 (3): 2075–81. PMID 8294459. 
  4. ^ a b "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H". 

Further reading[edit]