Neuropeptide S receptor

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Neuropeptide S receptor 1
Symbols NPSR1 ; ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1
External IDs OMIM608595 MGI2441738 HomoloGene45515 IUPHAR: 302 ChEMBL: 5162 GeneCards: NPSR1 Gene
Species Human Mouse
Entrez 387129 319239
Ensembl ENSG00000187258 ENSMUSG00000043659
UniProt Q6W5P4 Q8BZP8
RefSeq (mRNA) NM_001300933 NM_175678
RefSeq (protein) NP_001287862 NP_783609
Location (UCSC) Chr 7:
34.66 – 34.88 Mb
Chr 9:
24.1 – 24.32 Mb
PubMed search [1] [2]

The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins[1] which binds neuropeptide S (NPS).[2] It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand.

In the CNS, activation of the NPSR by NPS promotes arousal and anxiolytic-like effects.[3][4]

In addition, mututations in NPSR have been linked to a susceptibility to asthma.[5] Hence NPSR has also been called GPRA (G protein-coupled receptor for asthma susceptibility). Activation of NPSR in the airway epithelium has a number of effects including upregulation of matrix metalloproteinases which are involved in the pathogenesis of asthma.[6]

This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Mutations in this gene have also been associated with this disease. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[7]


  1. ^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517. 
  2. ^ Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Räisänen-Sokolowski A, Laitinen A, Laitinen LA, Kere J, Laitinen T (2005). "Characterization of GPRA, a novel G protein-coupled receptor related to asthma". Am. J. Respir. Cell Mol. Biol. 33 (3): 262–70. doi:10.1165/rcmb.2004-0405OC. PMID 15947423. 
  3. ^ Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O (2004). "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects". Neuron 43 (4): 487–97. doi:10.1016/j.neuron.2004.08.005. PMID 15312648. 
  4. ^ Okamura N, Reinscheid RK (2007). "Neuropeptide S: a novel modulator of stress and arousal". Stress (Amsterdam, Netherlands) 10 (3): 221–6. doi:10.1080/10253890701248673. PMID 17613937. 
  5. ^ Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Mäkelä S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullstén H, Leino M, Alenius H, Petäys T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J (2004). "Characterization of a common susceptibility locus for asthma-related traits". Science 304 (5668): 300–4. doi:10.1126/science.1090010. PMID 15073379. 
  6. ^ Vendelin J, Bruce S, Holopainen P, Pulkkinen V, Rytilä P, Pirskanen A, Rehn M, Laitinen T, Laitinen LA, Haahtela T, Saarialho-Kere U, Laitinen A, Kere J (2006). "Downstream target genes of the neuropeptide S-NPSR1 pathway". Hum. Mol. Genet. 15 (19): 2923–35. doi:10.1093/hmg/ddl234. PMID 16926187. 
  7. ^ "Entrez Gene: NPSR1 neuropeptide S receptor 1". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.