Prolactin receptor

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prolactin receptor
Symbol PRLR
Entrez 5618
HUGO 9446
OMIM 176761
RefSeq NM_000949
UniProt P16471
Other data
Locus Chr. 5 p13-p12

The prolactin receptor (PRLR)—encoded by a gene on chromosome 5p13-14—interacts with prolactin as a transmembrane receptor. Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region. The PRLR also binds and is activated by growth hormone (GH) and human placental lactogen (hPL) in addition to prolactin.

The PRLR is a cytokine receptor[1]and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway,[2][3] Ras-Raf-MAPK, and PI3K/AKT/mTOR pathway.[4]

The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.[5][6]

See also[edit]


  1. ^ Trott JF, Schennink A, Petrie WK, Manjarin R, VanKlompenberg MK, Hovey RC (May 2012). "Triennial Lactation Symposium: Prolactin: The multifaceted potentiator of mammary growth and function". Journal of Animal Science. 90 (5): 1674–86. doi:10.2527/jas.2011-4682. PMID 22205663. 
  2. ^ Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS (August 2010). "Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling". Molecular and Cellular Endocrinology. 325 (1-2): 143–9. doi:10.1016/j.mce.2010.05.010. PMC 2902710Freely accessible. PMID 20562009. 
  3. ^ Helmer RA, Dertien JS, Chilton BS (May 2011). "Prolactin induces Jak2 phosphorylation of RUSHY195". Molecular and Cellular Endocrinology. 338 (1-2): 79–83. doi:10.1016/j.mce.2011.03.009. PMID 21457752. 
  4. ^ Clevenger CV, Furth PA, Hankinson SE, Schuler LA (February 2003). "The role of prolactin in mammary carcinoma". Endocrine Reviews. 24 (1): 1–27. doi:10.1210/er.2001-0036. PMC 1698952Freely accessible. PMID 12588805. 
  5. ^ Horseman ND (6 December 2012). Prolactin. Springer Science & Business Media. pp. 227–. ISBN 978-1-4615-1683-5. 
  6. ^ Bland KI, Copeland EM (9 September 2009). The Breast: Comprehensive Management of Benign and Malignant Diseases. Elsevier Health Sciences. pp. 44–45. ISBN 1-4377-1121-9. 

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