Prolactin receptor

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prolactin receptor
Identifiers
Symbol PRLR
Entrez 5618
HUGO 9446
OMIM 176761
PDB 1RW5
RefSeq NM_000949
UniProt P16471
Other data
Locus Chr. 5 p13-p12

The prolactin receptor (PRLR)—encoded by a gene on chromosome 5p13-14—interacts with prolactin as a transmembrane receptor. Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region. The PRLR also binds and is activated by growth hormone (GH) and human placental lactogen (hPL) in addition to prolactin.

The PRLR is a cytokine receptor,[1] and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway,[2][3] Ras-Raf-MAPK, and PI3K/AKT/mTOR pathway.[4]

The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.[5][6]

References[edit]

  1. ^ Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
  2. ^ Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.
  3. ^ Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.
  4. ^ The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.
  5. ^ Nelson D. Horseman (6 December 2012). Prolactin. Springer Science & Business Media. pp. 227–. ISBN 978-1-4615-1683-5. 
  6. ^ Kirby I. Bland; Edward M. Copeland III (9 September 2009). The Breast: Comprehensive Management of Benign and Malignant Diseases. Elsevier Health Sciences. pp. 44–45. ISBN 1-4377-1121-9. 

External links[edit]