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Protein PTPRS PDB 2fh7.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PTPRS, PTPSIGMA, protein tyrosine phosphatase, receptor type S
External IDs MGI: 97815 HomoloGene: 20626 GeneCards: 5802
RNA expression pattern
PBB GE PTPRS 210823 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 5.16 – 5.34 Mb Chr 17: 56.41 – 56.48 Mb
PubMed search [1] [2]
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Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene.[1][2][3]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.[3]

Clinical significance[edit]

A PTPRS protein mimetic may improve muscular and bladder control in rats with spinal cord injuries.[4][5]


PTPRS has been shown to interact with:


  1. ^ Wagner J, Gordon LA, Heng HH, Tremblay ML, Olsen AS (Mar 1997). "Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3". Genomics 38 (1): 76–8. doi:10.1006/geno.1996.0594. PMID 8954782. 
  2. ^ a b Pulido R, Serra-Pagès C, Tang M, Streuli M (Jan 1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc Natl Acad Sci U S A 92 (25): 11686–90. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829. 
  3. ^ a b "Entrez Gene: PTPRS protein tyrosine phosphatase, receptor type, S". 
  4. ^ a b Lang BT, Cregg JM, DePaul MA, Tran AP, Xu K, Dyck SM, Madalena KM, Brown BP, Weng Y, Li S, Karimi-Abdolrezaee S, Busch SA, Shen Y, Silver J (2014). "Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury". Nature. doi:10.1038/nature13974. PMID 25470046. 
  5. ^ Maggie Fox (3 December 2014). "'Unprecedented': Drug May Help Heal Damaged Spine". NBC. Retrieved December 8, 2014. 
  6. ^ Wallace MJ, Fladd C, Batt J, Rotin D (May 1998). "The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma". Mol. Cell. Biol. 18 (5): 2608–16. PMC 110640. PMID 9566880. 
  7. ^ Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jun 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153. 

Further reading[edit]

  • Adachi M, Sekiya M, Arimura Y, Takekawa M, Itoh F, Hinoda Y, Imai K, Yachi A (1992). "Protein-tyrosine phosphatase expression in pre-B cell NALM-6.". Cancer Res. 52 (3): 737–40. PMID 1370651. 
  • Endo N, Rutledge SJ, Opas EE, Vogel R, Rodan GA, Schmidt A (1997). "Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates.". J. Bone Miner. Res. 11 (4): 535–43. doi:10.1002/jbmr.5650110415. PMID 8992885. 
  • Norris K, Norris F, Kono DH, Vestergaard H, Pedersen O, Theofilopoulos AN, Møller NP (1997). "Expression of protein-tyrosine phosphatases in the major insulin target tissues.". FEBS Lett. 415 (3): 243–8. doi:10.1016/S0014-5793(97)01133-2. PMID 9357975. 
  • Wallace MJ, Fladd C, Batt J, Rotin D (1998). "The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma.". Mol. Cell. Biol. 18 (5): 2608–16. PMC 110640. PMID 9566880. 
  • Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153. 
  • Haworth K, Shu KK, Stokes A, Morris R, Stoker A (1998). "The expression of receptor tyrosine phosphatases is responsive to sciatic nerve crush.". Mol. Cell. Neurosci. 12 (3): 93–104. doi:10.1006/mcne.1998.0707. PMID 9790732. 
  • Elchebly M, Wagner J, Kennedy TE, Lanctôt C, Michaliszyn E, Itié A, Drouin J, Tremblay ML (1999). "Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma.". Nat. Genet. 21 (3): 330–3. doi:10.1038/6859. PMID 10080191. 
  • Wallace MJ, Batt J, Fladd CA, Henderson JT, Skarnes W, Rotin D (1999). "Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma.". Nat. Genet. 21 (3): 334–8. doi:10.1038/6866. PMID 10080192. 
  • Suárez Pestana E, Tenev T, Gross S, Stoyanov B, Ogata M, Böhmer FD (1999). "The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal growth factor receptor in A431 cells.". Oncogene 18 (28): 4069–79. doi:10.1038/sj.onc.1202794. PMID 10435588. 
  • Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J (2003). "Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.". J. Biol. Chem. 277 (49): 47263–9. doi:10.1074/jbc.M205810200. PMID 12376545. 
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Hu YF, Zhang HL, Cai T, Harashima S, Notkins AL (2006). "The IA-2 interactome.". Diabetologia 48 (12): 2576–81. doi:10.1007/s00125-005-0037-y. PMID 16273344. 
  • Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. 
  • Lajus S, Lang J (2006). "Splice variant 3, but not 2 of receptor protein-tyrosine phosphatase sigma can mediate stimulation of insulin-secretion by alpha-latrotoxin.". J. Cell. Biochem. 98 (6): 1552–9. doi:10.1002/jcb.20871. PMID 16552719. 
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.