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Dimetindene

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Dimetindene
Clinical data
Trade namesFenistil
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, topical
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
Identifiers
  • N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethan-1-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.024.622 Edit this at Wikidata
Chemical and physical data
FormulaC20H24N2
Molar mass292.418 g/mol g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C
  • InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 checkY
  • Key:MVMQESMQSYOVGV-UHFFFAOYSA-N checkY
  (verify)

Dimetindene[1] (trade name Fenistil; other name dimethindene maleate) is an antiallergic drug. Dimetindene is an antihistamine/anticholinergic that is a selective H1 antagonist.[2] As dimetindene only minimally passes across the blood-brain barrier,[3] it is classified as a second generation antihistamine.

Clinical use

Dimetindene is used orally and topically as an antipruritic.[4] It is used topically to treat skin irritations, such as insect bites. Dimentidene is also administered orally to treat allergies, such as hay fever. Unlike first generation antihistamines, it causes only minimal drowsiness.

References

  1. ^ https://www.wikigenes.org/e/chem/e/21855.html
  2. ^ https://www.drugs.com/international/dimetindene.html
  3. ^ https://www.wikigenes.org/e/ref/e/1353628.html
  4. ^ Wexler, L. (1962). "A Clinical Evaluation of Dimethindene". Current Therapeutic Research, Clinical and Experimental. 4: 306–9. PMID 14006402.
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