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Symbols EFNA3 ; EFL2; EPLG3; Ehk1-L; LERK3
External IDs OMIM601381 MGI106644 HomoloGene3635 GeneCards: EFNA3 Gene
RNA expression pattern
PBB GE EFNA3 210132 at tn.png
More reference expression data
Species Human Mouse
Entrez 1944 13638
Ensembl ENSG00000143590 ENSMUSG00000028039
UniProt P52797 O08545
RefSeq (mRNA) NM_004952 NM_010108
RefSeq (protein) NP_004943 NP_034238
Location (UCSC) Chr 1:
155.04 – 155.06 Mb
Chr 3:
89.31 – 89.32 Mb
PubMed search [1] [2]

Ephrin-A3 is a protein that in humans is encoded by the EFNA3 gene.[1][2]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin.[2]


  1. ^ Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW (Jan 1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3". Genomics 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID 8660976. 
  2. ^ a b "Entrez Gene: EFNA3 ephrin-A3". 

Further reading[edit]