Leu-enkephalin

Leu-enkephalin
Names
	IUPAC names (2R)-2-[[(2R)-2-[[2-[[2-[[(2R)-2-amino-3-; (4-hydroxyphenyl)propanoyl]amino]acetyl]; amino]acetyl]amino]-3-phenylpropanoyl]; amino]-4-methylpentanoic acid
Identifiers
CAS Number	58822-25-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL8234 ;
ChemSpider	406229 ;
ECHA InfoCard	100.055.852
IUPHAR/BPS	1613;
PubChem CID	461776;
CompTox Dashboard (EPA)	DTXSID00905127 ;
	InChI InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1 Key: URLZCHNOLZSCCA-VABKMULXSA-N ; InChI=1/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1 Key: URLZCHNOLZSCCA-VABKMULXBR;
	SMILES O=C(O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)Cc2ccccc2)CC(C)C;
Properties
Chemical formula	C28H37N5O7
Molar mass	555.62268 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine. Leu-enkephalin has agonistic actions at both the μ- and δ-opioid receptors, with significantly greater preference for the latter. It has little to no effect on the κ-opioid receptor.

References

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