3D model (JSmol)
|Molar mass||376.45156 g/mol|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Mirfentanil is a fentanyl derivative with strong selectivity for the μ opioid receptor. At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained to discriminate morphine from naloxone.
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.
- France, CP; Winger, G; Medzihradsky, F; Seggel, MR; Rice, KC; Woods, JH (Aug 1991). "Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects". Journal of Pharmacology and Experimental Therapeutics. 258 (2): 502–10. PMID 1650830.
- Carr, DJ; Brockunier, LL; Scott, M; Bagley, JR; France, CP (Aug 1996). "Mirfentanil antagonizes morphine-induced suppression of splenic NK activity in mice". Immunopharmacology. 34 (1): 9–16. doi:10.1016/0162-3109(95)00051-8. PMID 8880221.
- Jane Mounteney; Isabelle Giraudon; Gleb Denissov; Paul Griffiths (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe". The international journal of drug policy. 26 (7): 626–631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511.
- Jerome R. Bagley; Wynn, Richard; Rudo, Frieda; Doorley, Brian; Spencer, Kenneth; Spaulding, Theodore (1989). "New 4-(heteroanilido)piperidines, structurally related to the pure opioidagonist fentanyl, with agonist and/or antagonist properties". Journal of Medicinal Chemistry. 32 (3): 663–71. doi:10.1021/jm00123a028. PMID 2563773.
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