P2RX3

P2RX3
Identifiers
Aliases	P2RX3, P2X3, purinergic receptor P2X 3
External IDs	OMIM: 600843; MGI: 1097160; HomoloGene: 1922; GeneCards: P2RX3; OMA:P2RX3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	57,372,396 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	85,037,462 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; apex of heart; ; left testis; ; right testis; ; left ventricle; ; right lobe of liver; ; left adrenal cortex; ; right adrenal gland; ; striated muscle tissue;
	Top expressed in
	lumbar spinal ganglion; ; spermatid; ; ganglion of vagus nerve; ; trigeminal ganglion; ; blastocyst; ; seminiferous tubule; ; greater petrosal nerve; ; spermatocyte; ; neural tube; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	purinergic nucleotide receptor activity; ion channel activity; ATP binding; extracellularly ATP-gated cation channel activity; nucleotide binding; ATP-gated ion channel activity;
Cellular component	integral component of membrane; rough endoplasmic reticulum; Golgi apparatus; membrane; receptor complex; dendritic spine; integral component of nuclear inner membrane; integral component of plasma membrane; soma; terminal bouton; axon; membrane raft; neuron projection; plasma membrane; Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; integral component of presynaptic membrane;
Biological process	peristalsis; response to ATP; response to hypoxia; positive regulation of calcium-mediated signaling; positive regulation of calcium ion transport into cytosol; urinary bladder smooth muscle contraction; response to mechanical stimulus; cation transport; response to heat; ion transport; behavioral response to formalin induced pain; response to organic substance; cation transmembrane transport; regulation of synaptic plasticity; neuromuscular synaptic transmission; positive regulation of sensory perception of pain; behavioral response to pain; response to cold; protein homooligomerization; response to carbohydrate; sensory perception of taste; signal transduction; neuronal action potential; response to temperature stimulus; chemical synaptic transmission; purinergic nucleotide receptor signaling pathway; blood coagulation; excitatory postsynaptic potential; protein homotrimerization; cellular response to ATP; modulation of chemical synaptic transmission; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	5024
	228139
	ENSG00000109991
	ENSMUSG00000027071
	P56373
	Q3UR32
	NM_002559
	NM_145526
	NP_002550
	NP_663501
	Wikidata
View/Edit Human	View/Edit Mouse

P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene.^[5]^[6]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109991 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027071 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garcia-Guzman M, Stuhmer W, Soto F (Sep 1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor". Brain Res Mol Brain Res. 47 (1–2): 59–66. doi:10.1016/S0169-328X(97)00036-3. PMID 9221902.
^ "Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3".

External links

P2RX3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109991 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027071 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9221902-5] Garcia-Guzman M, Stuhmer W, Soto F (Sep 1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor". Brain Res Mol Brain Res. 47 (1–2): 59–66. doi:10.1016/S0169-328X(97)00036-3. PMID 9221902.

[entrez-6] "Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3".

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P2RX3

See also

References

Further reading

External links