P2RX6

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P2RX6
Identifiers
Aliases P2RX6, P2RXL1, P2X6, P2XM, purinergic receptor P2X 6
External IDs MGI: 1337113 HomoloGene: 3975 GeneCards: P2RX6
RNA expression pattern
PBB GE P2RXL1 211147 s at fs.png

PBB GE P2RXL1 206880 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001159554
NM_005446
NM_001349874
NM_001349875
NM_001349876

NM_001159561
NM_011028

RefSeq (protein)

NP_001153026
NP_005437
NP_001336803
NP_001336804
NP_001336805

NP_001153033
NP_035158

Location (UCSC) Chr 22: 21.01 – 21.03 Mb Chr 16: 17.56 – 17.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.[3][4][5][6]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[6]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res. 57 (15): 3281–7. PMID 9242461. 
  4. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. PMID 10591208. doi:10.1038/990031. 
  5. ^ Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci. 16 (8): 2495–507. PMID 8786426. 
  6. ^ a b "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.