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Molar mass368.477 g·mol−1
3D model (JSmol)

Pentamorphone (14β-pentylaminomorphinone, RX-77989) is a semi-synthetic opiate derivative related to compounds such as morphine, hydromorphone and oxymorphone. Developed in 1984, it is a potent opioid analgesic several times stronger than fentanyl, and with a similarly fast onset of effects and short duration of action.[1][2] It was found to produce relatively little respiratory depression compared to other potent opioid agonists,[3] but its analgesic effects were somewhat disappointing in human trials,[4] and while pentamorphone had some slight advantages over fentanyl[5] these were not sufficient to warrant its introduction into clinical use.


  1. ^ Glass PS, Camporesi EM, Shafron D, Quill T, Reves JG (March 1989). "Evaluation of pentamorphone in humans: a new potent opiate". Anesthesia and Analgesia. 68 (3): 302–7. PMID 2465708.
  2. ^ Rudo FG, Wynn RL, Ossipov M, Ford RD, Kutcher BA, Carter A, Spaulding TC (October 1989). "Antinociceptive activity of pentamorphone, a 14-beta-aminomorphinone derivative, compared to fentanyl and morphine". Anesthesia and Analgesia. 69 (4): 450–6. PMID 2476953.
  3. ^ Afifi MS, Glass PS, Cohen NA, Shook JE, Camporesi EM (October 1990). "Depression of ventilatory responses to hypoxia and hypercapnia after pentamorphone". Anesthesia and Analgesia. 71 (4): 377–83. doi:10.1213/00000539-199010000-00010. PMID 1698039.
  4. ^ Wong HY, Parker RK, Fragen R, White PF (May 1991). "Pentamorphone for management of postoperative pain". Anesthesia and Analgesia. 72 (5): 656–60. PMID 1708214.
  5. ^ Kelly WB, Howie MB, Romanelli VA, Duarte JA, Rezaei H, McSweeney TD (August 1994). "A comparison of pentamorphone and fentanyl in balanced anaesthesia during general surgery". Canadian Journal of Anaesthesia. 41 (8): 703–9. doi:10.1007/BF03015625. PMID 7522977.