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Pheniprazine

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Pheniprazine
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • (1-Methyl-2-phenyl-ethyl)hydrazine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.215 Edit this at Wikidata
Chemical and physical data
FormulaC9H14N2
Molar mass150.22 g/mol g·mol−1
  • InChI=1S/C9H14N2/c1-8(11-10)7-9-5-3-2-4-6-9/h2-6,8,11H,7,10H2,1H3 checkY
  • Key:VXTWEDPZMSVFEF-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pheniprazine (INN; also known as amphethydrazine and amphetamine hydrazide; brand names Catron and Cavodil) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s.[1][2][3] It was also used in the treatment of angina pectoris and schizophrenia.[4][5] Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.[6][7][8]

See also

References

  1. ^ Lear, T. E; Browne, M. W; Greeves, J. A (1962). "A controlled trial of cavodil (pheniprazine) in depression". The Journal of Mental Science. 108: 856–58. PMID 13928843.
  2. ^ Fagervall, I; Ross, S. B (1986). "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors". Biochemical Pharmacology. 35 (8): 1381–7. PMID 2870717.
  3. ^ Eberson, L. E; Persson, K (1962). "Studies on Monoamine Oxidase Inhibitors. I. The Autoxidation of Beta-Phenylisopropylhydrazine As a Model Reaction for Irreversible Monoamine Oxidase Inhibition". Journal of Medicinal and Pharmaceutical Chemistry. 91: 738–52. PMID 14056405.
  4. ^ Sandler, G (1961). "Clinical evaluation of pheniprazine in angina pectoris". British Medical Journal. 1 (5228): 792–4. doi:10.1136/bmj.1.5228.792. PMC 1953879. PMID 13746179.
  5. ^ Wickstrom, L; Hahn, N (1962). "Beta-Phenylisoprophlhydrazine (Catran) in schizophrenia". Nordisk Medicin. 68: 1165–7. PMID 14000469.
  6. ^ Fentem, P. H; Howitt, G (1961). "Fatal jaundice after administration of pheniprazine". British Medical Journal. 2 (5267): 1616–7. doi:10.1136/bmj.2.5267.1616. PMC 1970739. PMID 13892290.
  7. ^ Frandsen, E (1962). "Toxic amblyopia during antidepressant treatment with pheniprazine (Catran)". Acta Psychiatrica Scandinavica. 38 (1): 1–14. doi:10.1111/j.1600-0447.1962.tb01780.x. PMID 13894598.
  8. ^ Thomsen, N. J (1963). "Optic neuritis after treatment with Catran". Ugeskrift for Laeger. 125: 138–9. PMID 13981222.


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