Proheptazine

Proheptazine
Clinical data
ATC code	none;
Legal status
Legal status	CA: Schedule I; DE: Anlage I (Authorized scientific use only); US: Schedule I;
Identifiers
	IUPAC name 1,3-dimethyl-4-phenylazepan-4-yl propionate;
CAS Number	77-14-5;
PubChem CID	60969;
ChemSpider	54931 ;
UNII	S23189WW7E;
CompTox Dashboard (EPA)	DTXSID50861628 ;
ECHA InfoCard	100.000.916
Chemical and physical data
Formula	C17H25NO2
Molar mass	275.39 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC2(c1ccccc1)CCCN(C)CC2C)CC;
	InChI InChI=1S/C17H25NO2/c1-4-16(19)20-17(15-9-6-5-7-10-15)11-8-12-18(3)13-14(17)2/h5-7,9-10,14H,4,8,11-13H2,1-3H3 ; Key:ZXWAUWBYASJEOE-UHFFFAOYSA-N ;
	(verify)

Proheptazine is an opioid analgesic from the phenazepine family. It was invented in the 1960s.^[1]

Proheptazine produces similar effects to other opioids, including analgesia, sedation, euphoria, dizziness and nausea.

In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9643 and a 2013 annual aggregrate manufacturing quota of zero. The salts in use are the citrate (free base conversion ratio 0.589), hydrobromide (0.773), and hydrochloride (0.883). ^[2]^[3]

References

^ Diamond J, Bruce WF, Tyson FT. Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine). Journal of Medicinal Chemistry. 1964 Jan;7:57-60.
^ http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm
^ http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html

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[1] Diamond J, Bruce WF, Tyson FT. Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine). Journal of Medicinal Chemistry. 1964 Jan;7:57-60.

[2] ttp://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm

[3] ttp://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html

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