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Transmembrane phosphatase with tensin homology
Symbols TPTE ; CT44; PTEN2
External IDs OMIM604336 MGI2446460 HomoloGene50411 GeneCards: TPTE Gene
EC number
Species Human Mouse
Entrez 7179 234129
Ensembl ENSG00000274391 ENSMUSG00000031481
UniProt P56180 E9Q3G1
RefSeq (mRNA) NM_001290224 NM_181851.3
RefSeq (protein) NP_001277153 NP_954866.2
Location (UCSC) Chr 21:
10.52 – 10.61 Mb
Chr 8:
23.39 – 23.48 Mb
PubMed search [1] [2]

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.[1][2]


TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[2] TPTE is believed to lack phosphatase activity; however, the closely related protein TPIP, also called TPTE2 is an active phosphatase with activity against inositol phospholipid substrates.[3] TPTE and TPIP are the mammalian homologues to the family of voltage sensitive phosphatases.


  1. ^ Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID 14659893. 
  2. ^ a b "Entrez Gene: TPTE transmembrane phosphatase with tensin homology". 
  3. ^ Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Curr. Biol. 17 (2): 115–25. doi:10.1016/j.cub.2006.12.026. PMC 1885949. PMID 17240336. 

Further reading[edit]

  • Antonarakis SE (1998). "10 years of Genomics, chromosome 21, and Down syndrome.". Genomics 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID 9693027. 
  • Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet. 105 (5): 399–409. doi:10.1007/s004390051122. PMID 10598804. 
  • Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21.". Hum. Genet. 107 (2): 127–31. doi:10.1007/s004390000343. PMID 11030409. 
  • Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase.". J. Biol. Chem. 276 (24): 21745–53. doi:10.1074/jbc.M101480200. PMID 11279206. 
  • Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family.". Hum. Genet. 109 (6): 569–75. doi:10.1007/s004390100607. PMID 11810268.