TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositolphospholipids. TPTE is believed to lack phosphatase activity; however, the closely related protein TPIP, also called TPTE2 is an active phosphatase with activity against inositol phospholipid substrates. TPTE and TPIP are the mammalian homologues to the family of voltage sensitive phosphatases.
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