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Dual specificity phosphatase 1
Symbols DUSP1 ; CL100; HVH1; MKP-1; MKP1; PTPN10
External IDs OMIM600714 MGI105120 HomoloGene3254 ChEMBL: 6026 GeneCards: DUSP1 Gene
EC number,
RNA expression pattern
PBB GE DUSP1 201041 s at tn.png
PBB GE DUSP1 201044 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1843 19252
Ensembl ENSG00000120129 ENSMUSG00000024190
UniProt P28562 P28563
RefSeq (mRNA) NM_004417 NM_013642
RefSeq (protein) NP_004408 NP_038670
Location (UCSC) Chr 5:
172.77 – 172.77 Mb
Chr 17:
26.51 – 26.51 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.[1][2]


The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.[3]


DUSP1 has been shown to interact with MAPK14,[4][5] MAPK1[5][6] and MAPK8.[5]


  1. ^ Keyse SM, Emslie EA (Oct 1992). "Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase". Nature 359 (6396): 644–7. doi:10.1038/359644a0. PMID 1406996. 
  2. ^ Martell KJ, Kwak S, Hakes DJ, Dixon JE, Trent JM (Jul 1994). "Chromosomal localization of four human VH1-like protein-tyrosine phosphatases". Genomics 22 (2): 462–4. doi:10.1006/geno.1994.1411. PMID 7806236. 
  3. ^ "Entrez Gene: DUSP1 dual specificity phosphatase 1". 
  4. ^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". The Journal of Biological Chemistry 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773. 
  5. ^ a b c Slack DN, Seternes OM, Gabrielsen M, Keyse SM (May 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". The Journal of Biological Chemistry 276 (19): 16491–500. doi:10.1074/jbc.M010966200. PMID 11278799. 
  6. ^ Calvisi DF, Pinna F, Meloni F, Ladu S, Pellegrino R, Sini M, Daino L, Simile MM, De Miglio MR, Virdis P, Frau M, Tomasi ML, Seddaiu MA, Muroni MR, Feo F, Pascale RM (Jun 2008). "Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma". Cancer Research 68 (11): 4192–200. doi:10.1158/0008-5472.CAN-07-6157. PMID 18519678. 

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