PTPN9

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PTPN9
Protein PTPN9 PDB 2pa5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTPN9, MEG2, PTPMEG2, protein tyrosine phosphatase, non-receptor type 9
External IDs MGI: 1928376 HomoloGene: 2121 GeneCards: PTPN9
RNA expression pattern
PBB GE PTPN9 202958 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002833

NM_019651

RefSeq (protein)

NP_002824

NP_062625.2
NP_062625

Location (UCSC) Chr 15: 75.46 – 75.58 Mb Chr 9: 56.99 – 57.06 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.[3][4]

Function[edit]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by poly-phosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.[4]

References[edit]

Further reading[edit]