TIE1

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Structures	Swiss-model
Domains	InterPro

tyrosine kinase with immunoglobulin-like and EGF-like domains 1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
Symbol	TIE1
Alt. symbols	TIE, JTK14
NCBI gene	7075
HGNC	11809
OMIM	600222
RefSeq	NM_005424
UniProt	P35590
Other data
EC number	2.7.1.112
Locus	Chr. 1 p34-p33
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.^[1]

Function

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells^[2] and platelets.^[3] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.^[4]

References

^ Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol. Cell. Biol. 12 (4): 1698–707. PMC 369613. PMID 1312667.
^ Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID 8570217.
^ Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (Nov 2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". J Vasc Res. 2000 Nov-Dec;37(6):437-42. PMID 11146396
^ Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochem. Biophys. Res. Commun. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.

External links

Receptor,+TIE-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[pmid1312667-1] Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol. Cell. Biol. 12 (4): 1698–707. PMC 369613. PMID 1312667.

[2] Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID 8570217.

[3] Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (Nov 2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". J Vasc Res. 2000 Nov-Dec;37(6):437-42. PMID 11146396

[pmid18448073-4] Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochem. Biophys. Res. Commun. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)